Last updated August 22, 2026
Key finding
Physical activity increased by 0.6 MET h/d in the intervention group and decreased by 4.6 MET h/d in the standard care group (p = 0.001).
This randomized controlled trial evaluated the impact of a lifestyle intervention on type 2 diabetes remission, finding a higher remission rate in the intervention group compared to standard care.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This randomized controlled trial evaluated the impact of a lifestyle intervention on type 2 diabetes remission, finding a higher remission rate in the intervention group compared to standard care.
These findings suggest that lifestyle interventions could be a valuable strategy for managing prediabetes and potentially achieving diabetes remission. Although the results did not reach statistical significance, the trend indicates that such interventions may benefit a subset of patients, highlighting the importance of lifestyle changes in diabetes management.
The remission rate did not reach statistical significance. The sample size may limit the generalizability of the findings. Changes in metabolic parameters were not statistically significant.
Published in
Publication details and source links for this paper.
Mathias R, Mette YJ, Christopher SM, et al. Intensive lifestyle intervention induces partial or complete type 2 diabetes remission: a randomized controlled trial. Diabetes, Obesity & Metabolism. 2019;21(10):2257-2266. doi:10.1111/dom.13802
23% of the intervention group achieved partial or complete T2D remission compared to 7% in standard care (p = 0.08).
HbA1c decreased by 2.7 mmol/mol in the intervention group versus 3.2 mmol/mol in standard care (p = 0.80).
Weight decreased by 1.39 kg in the intervention group compared to 0.79 kg in standard care (p = 0.17).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Lifestyle intervention for prediabetes and 2-hour plasma glucose, Body Mass Index (BMI) change, Body fat mass, and 14 more.
This study contributes evidence to
Primary intervention
Lifestyle intervention for prediabetes
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
6
Related topics
17
Evidence pairs
1250
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_intervention_and_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Lifestyle intervention for prediabetes → 2-hour plasma glucose
Lifestyle intervention for prediabetes → 2-hour plasma glucose
Lifestyle intervention for prediabetes → Body fat mass
Lifestyle intervention for prediabetes → Body fat mass
Lifestyle intervention for prediabetes → Body Mass Index (BMI) change
Lifestyle intervention for prediabetes → Body Mass Index (BMI) change
Lifestyle intervention for prediabetes → Diastolic blood pressure
Lifestyle intervention for prediabetes → Diastolic blood pressure
Lifestyle intervention for prediabetes → Fasting insulin levels
Lifestyle intervention for prediabetes → Fasting insulin levels
Lifestyle intervention for prediabetes → Fasting Plasma Glucose (FPG)
Lifestyle intervention for prediabetes → Fasting Plasma Glucose (FPG)
Lifestyle intervention for prediabetes → HDL cholesterol
Lifestyle intervention for prediabetes → HDL cholesterol
Lifestyle intervention for prediabetes → LDL cholesterol
Lifestyle intervention for prediabetes → LDL cholesterol
Lifestyle intervention for prediabetes → Lean body mass
Lifestyle intervention for prediabetes → Lean body mass
Lifestyle intervention for prediabetes → Partial or complete type 2 diabetes remission
Lifestyle intervention for prediabetes → Partial or complete type 2 diabetes remission
Lifestyle intervention for prediabetes → Percentage contribution of ultra-processed foods to total energy intake
Lifestyle intervention for prediabetes → Percentage contribution of ultra-processed foods to total energy intake
Lifestyle intervention for prediabetes → Physical activity changes
Lifestyle intervention for prediabetes → Physical activity changes
Lifestyle intervention for prediabetes → Systolic blood pressure
Lifestyle intervention for prediabetes → Systolic blood pressure
Lifestyle intervention for prediabetes → Total cholesterol
Lifestyle intervention for prediabetes → Total cholesterol
Lifestyle intervention for prediabetes → Triglycerides
Lifestyle intervention for prediabetes → Triglycerides
Lifestyle intervention for prediabetes → Weight change
Lifestyle intervention for prediabetes → Weight change
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Lifestyle intervention for prediabetes and HbA1c, Lifestyle intervention for prediabetes and Postprandial and OGTT Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Lifestyle intervention for prediabetes
Contributes to Lifestyle intervention for prediabetes evidence base.
All studies measuring Postprandial and OGTT Glucose
Measures Postprandial and OGTT Glucose as a key outcome.
All studies measuring Blood Pressure
Measures Blood Pressure as a key outcome.
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9 results
4 results
9 results
9 results
4 results
Generated from the study's connected evidence using Evidence Intelligence™.
Lifestyle intervention for prediabetes may improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 85.2 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Lifestyle intervention for prediabetes may improve 2-hour plasma glucose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
2-hour plasma glucose
EvidenceScore™ Strong | EvidenceScore™ 78.3 | weak positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Lifestyle intervention for prediabetes may improve Diastolic blood pressure.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Diastolic blood pressure
EvidenceScore™ Strong | EvidenceScore™ 76.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Lifestyle intervention for prediabetes may improve Fasting insulin levels.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Fasting insulin levels
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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