Research Summary

Analyzed using Evidence Intelligence™

Diabetes-specific formula improves recovery in non-diabetic stroke patients

Last updated August 22, 2026

Key finding

In CG, there were more cases of hyperglycaemia on the 5th day post-NE (13(65%) vs 7(35%), p < 0.01).

This study evaluated the impact of a diabetes-specific enteral formula on non-diabetic stroke patients, finding reduced hyperglycaemia and improved oral recovery rates.

Quick read

Study at a glance

The essential study design details in one scan.

EvidenceScore™

Moderate

Study type

RCTs

Follow-up

Short-Term (≤3 mo)

Risk of bias

Some Concerns

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Plain-language summary

What this paper says

A plain-language read of the study’s main message and where it applies.

Study focus

This study evaluated the impact of a diabetes-specific enteral formula on non-diabetic stroke patients, finding reduced hyperglycaemia and improved oral recovery rates.

Clinical relevance

Managing blood sugar levels is crucial for stroke recovery, as hyperglycaemia can worsen outcomes. This study suggests that using a diabetes-specific enteral formula in non-diabetic stroke patients may help mitigate these risks and enhance recovery, potentially influencing dietary practices in clinical settings.

Keep in mind

The study's sample size may limit the generalizability of the findings. The trial only included non-diabetic patients, which may not apply to diabetic populations. Effectiveness measures were deemed unclear, limiting definitive conclusions.

Published in

Journal Reference

Publication details and source links for this paper.

Juan JL, Esther DG, David P, et al. The use of a diabetes-specific enteral formula in non-diabetic patients admitted with acute stroke reduced the risk of developing hyperglycaemia and improved the rate of oral route recovery. Nutrition & Diabetes. 2024;14:34. doi:10.1038/s41387-024-00292-4

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Main Effects

The diabetes-specific formula group had 6 more cases of hyperglycaemia compared to the control group (p < 0.01).

Oral route recovery was significantly better in the diabetes-specific formula group with 6 more patients recovering (p = 0.04).

No significant differences were found in length of stay between groups (p = 0.19).

Mortality rates were similar between groups (p = 0.8).

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to Diabetes-specific nutritional formula-pro (DSNF-Pro) and Incidence of hyperglycaemia during enteral nutrition treatment, Length of stay in intensive care, Mortality rate at 30 days post-intervention, and 1 more.

This study contributes evidence to

Intervention

Diabetes-specific nutritional formula-pro (DSNF-Pro)

Outcome

Incidence of hyperglycaemia during enteral nutrition treatment

Primary intervention

Diabetes-specific nutritional formula-pro (DSNF-Pro)

Primary outcomes

Incidence of hyperglycaemia during enteral nutrition treatment
Length of stay in intensive care
Mortality rate at 30 days post-intervention

Primary intervention

Diabetes-specific nutritional formula-pro (DSNF-Pro)

Primary outcomes

Incidence of hyperglycaemia during enteral nutrition treatment Length of stay in intensive care Mortality rate at 30 days post-intervention

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

Evidence pairs

Relationships

Evidence topics

contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 50

Why it is useful

Contributes to 4 evidence relationships
Includes primary outcome data
Linked to 0 direct semantic evidence topics

Core evidence

Study findings

The primary outcomes reported in this study.

Incidence of hyperglycaemia during enteral nutrition treatment

Diabetes-specific nutritional formula-pro (DSNF-Pro) → Incidence of hyperglycaemia during enteral nutrition treatment

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 25; Negative
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Length of stay in intensive care

Diabetes-specific nutritional formula-pro (DSNF-Pro) → Length of stay in intensive care

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Mortality rate at 30 days post-intervention

Diabetes-specific nutritional formula-pro (DSNF-Pro) → Mortality rate at 30 days post-intervention

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Rate of oral route recovery

Diabetes-specific nutritional formula-pro (DSNF-Pro) → Rate of oral route recovery

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 100; Very Positive
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Evidence Library

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Evidence Suggest

Diabetes-specific formula reduced hyperglycaemia by 6 cases (p < 0.01).
Oral recovery improved by 6 patients in the diabetes-specific group (p = 0.04).
No significant difference in length of stay or mortality rates.

Who this applies to

Non-diabetic patients admitted with acute stroke.
Patients requiring enteral nutrition during stroke recovery.

Keep in Mind

The findings may not be applicable to diabetic patients.
Results are based on a specific population and may not generalize to all stroke patients.
Further research is needed to confirm long-term effects and safety.

Between the Lines

The study's sample size may limit the generalizability of the findings.
The trial only included non-diabetic patients, which may not apply to diabetic populations.
Effectiveness measures were deemed unclear, limiting definitive conclusions.

Evidence Library

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Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

This study contributes to evidence on Diabetes-specific nutritional formula-pro (DSNF-Pro) and Incidence of hyperglycaemia during enteral nutrition treatment, Diabetes-specific nutritional formula-pro (DSNF-Pro) and Length of stay in intensive care.

Related evidence relationships

Explore in Evidence Explorer

This study contributes to the evidence on the following intervention-outcome relationships.

Diet and Nutrition

Detailed evidence

Diabetes-specific nutritional formula-pro (DSNF-Pro) → Incidence of hyperglycaemia during enteral nutrition treatment

Diet and Nutrition

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 25; Negative
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

View evidence

Diet and Nutrition

Detailed evidence

Diabetes-specific nutritional formula-pro (DSNF-Pro) → Length of stay in intensive care

Diet and Nutrition

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

View evidence

Included in these evidence collections

Curated evidence collections and hubs this study is part of.

Diabetes-specific nutritional formula-pro (DSNF-Pro) Evidence Hub

All studies on Diabetes-specific nutritional formula-pro (DSNF-Pro)

1 studies

intervention_hub

Contributes to Diabetes-specific nutritional formula-pro (DSNF-Pro) evidence base.

Incidence of hyperglycaemia during enteral nutrition treatment Evidence Hub

All studies measuring Incidence of hyperglycaemia during enteral nutrition treatment

1 studies

outcome_hub

Measures Incidence of hyperglycaemia during enteral nutrition treatment as a key outcome.

Length of stay in intensive care Evidence Hub

All studies measuring Length of stay in intensive care

1 studies

outcome_hub

Measures Length of stay in intensive care as a key outcome.

Recent Diabetes Research

Latest published studies

recency_collection

Published within the last 2 years.

Explore more in Evidence Explorer

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All studies on Diabetes-specific nutritional formula-pro (DSNF-Pro) and Incidence of hyperglycaemia during enteral nutrition treatment

Intervention: Diabetes-specific nutritional formula-pro (DSNF-Pro)Outcome: Incidence of hyperglycaemia during enteral nutrition treatment

1 results

All studies on Diabetes-specific nutritional formula-pro (DSNF-Pro) and Length of stay in intensive care

Intervention: Diabetes-specific nutritional formula-pro (DSNF-Pro)Outcome: Length of stay in intensive care

1 results

All studies on Diabetes-specific nutritional formula-pro (DSNF-Pro)

Intervention: Diabetes-specific nutritional formula-pro (DSNF-Pro)

1 results

All studies measuring Incidence of hyperglycaemia during enteral nutrition treatment

Outcome: Incidence of hyperglycaemia during enteral nutrition treatment

1 results

All studies measuring Length of stay in intensive care

Outcome: Length of stay in intensive care

1 results

Questions answered by this study

Generated from the study's connected evidence using Evidence Intelligence™.

Does Diabetes-specific nutritional formula-pro (DSNF-Pro) improve rate of oral route recovery?

Emerging Evidence

Diabetes-specific nutritional formula-pro (DSNF-Pro) appears to improve Rate of oral route recovery.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
Rate of oral route recovery
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Consistency cannot yet be determined.
Population details are unavailable.

View Full Evidence

Does Diabetes-specific nutritional formula-pro (DSNF-Pro) improve length of stay in intensive care?

Emerging Evidence

Current evidence does not show a clear benefit of Diabetes-specific nutritional formula-pro (DSNF-Pro) for Length of stay in intensive care.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
Length of stay in intensive care
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Consistency cannot yet be determined.
Population details are unavailable.

View Full Evidence

Does Diabetes-specific nutritional formula-pro (DSNF-Pro) improve mortality rate at 30 days post-intervention?

Emerging Evidence

Current evidence does not show a clear benefit of Diabetes-specific nutritional formula-pro (DSNF-Pro) for Mortality rate at 30 days post-intervention.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
Mortality rate at 30 days post-intervention
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Consistency cannot yet be determined.
Population details are unavailable.

View Full Evidence

Does Diabetes-specific nutritional formula-pro (DSNF-Pro) improve incidence of hyperglycaemia during enteral nutrition treatment?

Emerging Evidence

Diabetes-specific nutritional formula-pro (DSNF-Pro) may worsen Incidence of hyperglycaemia during enteral nutrition treatment or be associated with harm.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
Incidence of hyperglycaemia during enteral nutrition treatment
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | moderate negative | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Consistency cannot yet be determined.
Population details are unavailable.

View Full Evidence

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All studies on Diabetes-specific nutritional formula-pro (DSNF-Pro) and Incidence of hyperglycaemia during enteral nutrition treatment All studies on Diabetes-specific nutritional formula-pro (DSNF-Pro) and Length of stay in intensive care All studies on Diabetes-specific nutritional formula-pro (DSNF-Pro) and Mortality rate at 30 days post-intervention All studies on Diabetes-specific nutritional formula-pro (DSNF-Pro) and Rate of oral route recovery

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