Last updated July 3, 2026
Key finding
Glucose iAUC0–3h was 59% lower in test vs control.
The study evaluated the impact of a diabetes-specific protein supplement (DSPS) as a partial breakfast replacement on glycemic control in adults with type 2 diabetes, finding significant reductions in postprandial glucose levels.
Quick read
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EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
The study evaluated the impact of a diabetes-specific protein supplement (DSPS) as a partial breakfast replacement on glycemic control in adults with type 2 diabetes, finding significant reductions in postprandial glucose levels.
Improving glycemic control is crucial for managing type 2 diabetes and reducing the risk of complications. The significant reductions in postprandial glucose levels observed with DSPS indicate its potential as an effective dietary intervention for individuals with diabetes, offering a practical approach to enhance dietary management.
The study's sample size and demographic characteristics may limit generalizability. The long-term effects of DSPS on glycemic control were not assessed. Insulin response did not show significant differences, indicating variability in individual responses.
Published in
Publication details and source links for this paper.
Sheryl SS, Ami S, Natasha V, et al. DSPS as a Partial Breakfast Replacement Improves Glycemic Control in Adults with Type 2 Diabetes. Diabetes Therapy. 2025;17(2):271-285. doi:10.1007/s13300-025-01834-4
Postprandial glucose iAUC0–3h was 59% lower in the DSPS group compared to control (p = 0.001).
Peak glucose levels were significantly lower by 46% in the DSPS group (p = 0.001).
Protein intake increased by 8.8 g during the DSPS intervention.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Diabetes-specific nutritional formula-pro (DSNF-Pro), Isocaloric control breakfast and Glucose iAUC (OGTT), Mean amplitude of glycemic excursions (MAGE), Postprandial blood glucose, and 2 more.
This study contributes evidence to
Primary intervention
Diabetes-specific nutritional formula-pro (DSNF-Pro)
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
5
Evidence pairs
333
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
The primary outcomes reported in this study.
Diabetes-specific nutritional formula-pro (DSNF-Pro) → Glucose iAUC (OGTT)
Diabetes-specific nutritional formula-pro (DSNF-Pro) → Glucose iAUC (OGTT)
Diabetes-specific nutritional formula-pro (DSNF-Pro) → Mean amplitude of glycemic excursions (MAGE)
Diabetes-specific nutritional formula-pro (DSNF-Pro) → Mean amplitude of glycemic excursions (MAGE)
Diabetes-specific nutritional formula-pro (DSNF-Pro) → Postprandial blood glucose
Diabetes-specific nutritional formula-pro (DSNF-Pro) → Postprandial blood glucose
Diabetes-specific nutritional formula-pro (DSNF-Pro) → Protein intake change
Diabetes-specific nutritional formula-pro (DSNF-Pro) → Protein intake change
Isocaloric control breakfast → Postprandial insulin incremental area under the curve (iAUC0–3h)
Isocaloric control breakfast → Postprandial insulin incremental area under the curve (iAUC0–3h)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Diabetes-specific nutritional formula-pro (DSNF-Pro) and Postprandial and OGTT Glucose, Diabetes-specific nutritional formula-pro (DSNF-Pro) and Glucose Variability.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies on Diabetes-specific nutritional formula-pro (DSNF-Pro)
Contributes to Diabetes-specific nutritional formula-pro (DSNF-Pro) evidence base.
All studies measuring Postprandial and OGTT Glucose
Measures Postprandial and OGTT Glucose as a key outcome.
All studies measuring Glucose Variability
Measures Glucose Variability as a key outcome.
Latest published studies
Published within the last 2 years.
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2 results
1 results
2 results
2 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Diabetes-specific nutritional formula-pro (DSNF-Pro) appears to improve Glucose iAUC (OGTT).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Glucose iAUC (OGTT)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Diabetes-specific nutritional formula-pro (DSNF-Pro) appears to improve Mean amplitude of glycemic excursions (MAGE).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Mean amplitude of glycemic excursions (MAGE)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Diabetes-specific nutritional formula-pro (DSNF-Pro) appears to improve Postprandial blood glucose.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Postprandial blood glucose
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Diabetes-specific nutritional formula-pro (DSNF-Pro) appears to improve Protein intake change.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Protein intake change
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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