Research Summary

DSNF-Pro improves glycemic control in prediabetes

Moderate confidence

Low bias

Last updated June 17, 2026

Key Takeaway:

The study evaluated the effects of a diabetes-specific nutritional formula (DSNF-Pro) on postprandial glycemic control in prediabetic participants, finding significant reductions in glucose and c-peptide levels compared to a standard formula.

Study at a Glance

Participants

Intervention

Diabetes-specific nutritional formula-pro (DSNF-Pro)

Outcomes

Postprandial plasma glucose incremental area under the curve (iAUC), Postprandial serum c-peptide incremental area under the curve (iAUC), Postprandial serum insulin incremental area under the curve (iAUC)

Funding

Non-Industry Sponsored

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Main Effects

DSNF-Pro reduced postprandial plasma glucose iAUC by 73.4% (p = 0.0001) compared to STNF.

DSNF-Pro reduced postprandial serum c-peptide iAUC by 36.4% (p = 0.0001) compared to STNF.

No significant difference in postprandial serum insulin iAUC was found between DSNF-Pro and STNF (p = 0.3591).

Evidence Summary

Intervention	Outcome	Measured Change	Study Effect
Diabetes-specific nutritional formula-pro (DSNF-Pro) (Diet and Nutrition)	C-peptide incremental area under the curve (iAUC) (Glycemic Control)	Decrease	Strong
Diabetes-specific nutritional formula-pro (DSNF-Pro) (Diet and Nutrition)	Glucose iAUC (OGTT) (Glycemic Control)	Decrease	Strong
Diabetes-specific nutritional formula-pro (DSNF-Pro) (Diet and Nutrition)	Postprandial insulin AUC (Glycemic Control)	No Change	Unclear

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Evidence Suggest

DSNF-Pro significantly reduced glucose levels by 73.4%.
C-peptide levels decreased by 36.4% with DSNF-Pro.
No significant change in insulin levels was observed.

Who this applies to

Adults diagnosed with prediabetes.
Individuals seeking dietary interventions for glycemic control.

Keep in Mind

Results may not apply to populations outside the study group.
Further research is needed to confirm long-term effects.
The study's non-randomized design limits causal inferences.

Between the Lines

Non-randomized design may introduce bias.
Limited generalizability due to specific population characteristics.
Unmeasured confounders may affect outcomes.

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Journal Reference

Yeongtaek H, Minkyung B, Suk C, Hyunjung L. DSNF-Pro Improves Postprandial Glycemic Control in Prediabetes: A Cross-Over Trial. Nutrition & Diabetes. 2025;15:47. doi:10.1038/s41387-025-00399-2

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