Last updated June 17, 2026
Key finding
DSNF-Pro significantly reduced postprandial glucose iAUC by 73.4% (p = 0.0001) compared to STNF.
The study evaluated the effects of a diabetes-specific nutritional formula (DSNF-Pro) on postprandial glycemic control in prediabetic participants, finding significant reductions in glucose and c-peptide levels compared to a standard formula.
Quick read
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EvidenceScore™
Moderate
Study type
RCTs
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
The study evaluated the effects of a diabetes-specific nutritional formula (DSNF-Pro) on postprandial glycemic control in prediabetic participants, finding significant reductions in glucose and c-peptide levels compared to a standard formula.
Improving postprandial glycemic control is crucial for preventing the progression from prediabetes to type 2 diabetes. The significant reductions in glucose and c-peptide levels with DSNF-Pro suggest it could be a valuable dietary intervention for individuals at risk, potentially leading to better long-term health outcomes and reduced healthcare costs associated with diabetes management.
Non-randomized design may introduce bias. Limited generalizability due to specific population characteristics. Unmeasured confounders may affect outcomes.
Published in
Publication details and source links for this paper.
Yeongtaek H, Minkyung B, Suk C, Hyunjung L. DSNF-Pro Improves Postprandial Glycemic Control in Prediabetes: A Cross-Over Trial. Nutrition & Diabetes. 2025;15:47. doi:10.1038/s41387-025-00399-2
DSNF-Pro reduced postprandial plasma glucose iAUC by 73.4% (p = 0.0001) compared to STNF.
DSNF-Pro reduced postprandial serum c-peptide iAUC by 36.4% (p = 0.0001) compared to STNF.
No significant difference in postprandial serum insulin iAUC was found between DSNF-Pro and STNF (p = 0.3591).
Evidence network
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This study contributes evidence to Diabetes-specific nutritional formula-pro (DSNF-Pro) and C-peptide incremental area under the curve (iAUC), Glucose iAUC (OGTT), Postprandial insulin AUC.
This study contributes evidence to
Primary intervention
Diabetes-specific nutritional formula-pro (DSNF-Pro)
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
3
Evidence pairs
245
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Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Diabetes-specific nutritional formula-pro (DSNF-Pro) → C-peptide incremental area under the curve (iAUC)
Diabetes-specific nutritional formula-pro (DSNF-Pro) → C-peptide incremental area under the curve (iAUC)
Diabetes-specific nutritional formula-pro (DSNF-Pro) → Glucose iAUC (OGTT)
Diabetes-specific nutritional formula-pro (DSNF-Pro) → Glucose iAUC (OGTT)
Diabetes-specific nutritional formula-pro (DSNF-Pro) → Postprandial insulin AUC
Diabetes-specific nutritional formula-pro (DSNF-Pro) → Postprandial insulin AUC
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Diabetes-specific nutritional formula-pro (DSNF-Pro) and Postprandial and OGTT Glucose, Diabetes-specific nutritional formula-pro (DSNF-Pro) and Postprandial and OGTT Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies on Diabetes-specific nutritional formula-pro (DSNF-Pro)
Contributes to Diabetes-specific nutritional formula-pro (DSNF-Pro) evidence base.
All studies measuring Postprandial and OGTT Glucose
Measures Postprandial and OGTT Glucose as a key outcome.
Latest published studies
Published within the last 2 years.
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2 results
1 results
2 results
2 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Diabetes-specific nutritional formula-pro (DSNF-Pro) appears to improve Glucose iAUC (OGTT).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Glucose iAUC (OGTT)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Diabetes-specific nutritional formula-pro (DSNF-Pro) appears to improve C-peptide incremental area under the curve (iAUC).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
C-peptide incremental area under the curve (iAUC)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Diabetes-specific nutritional formula-pro (DSNF-Pro) for Postprandial insulin AUC.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Postprandial insulin AUC
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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