Last updated July 22, 2026
Key finding
HbA1c decreased by 1.1% in the 12g intervention group.
This study evaluated the effects of dietary fiber supplementation on liver fibrosis and glycemic control in patients with Type 2 diabetes and MASLD, finding significant improvements in HbA1c and FIB-4 levels.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study evaluated the effects of dietary fiber supplementation on liver fibrosis and glycemic control in patients with Type 2 diabetes and MASLD, finding significant improvements in HbA1c and FIB-4 levels.
These findings suggest that dietary fiber could be a valuable addition to the management of Type 2 diabetes and associated liver conditions. Improved glycemic control and reduced liver fibrosis can lead to better overall health outcomes for patients, potentially reducing the risk of complications associated with diabetes and liver disease.
The study did not measure long-term effects beyond the intervention period. Sample size and demographic diversity may limit generalizability. No significant changes in BMI were observed, which may affect interpretation.
Published in
Publication details and source links for this paper.
Xi-Shuang C, Hui-Zhen L, Fang H, et al. Dietary Fiber Improves Liver Fibrosis and Glycemic Control in Patients with Type 2 Diabetes and MASLD. Frontiers in Endocrinology. 2025;16:1623136. doi:10.3389/fendo.2025.1623136
HbA1c decreased by 1.1% in the 12g fiber group (p=0.001).
HbA1c decreased by 1.6% in the 24g fiber group (p=0.001).
FIB-4 levels decreased significantly in both the 12g and 24g fiber groups.
Evidence network
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This study contributes evidence to DSMES, Dietary fibre supplement (YMETA) and BMI, FIB-4 index, Fasting Plasma Glucose (FPG), and 1 more.
This study contributes evidence to
Primary intervention
DSMES
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Evidence pairs
793
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Contributes evidence
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Contributes evidence
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Contributes evidence
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Contributes evidence
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Primary evidence
Evidence relationship
Related evidence
Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Dietary fibre supplement (YMETA) → Fasting Plasma Glucose (FPG)
Dietary fibre supplement (YMETA) → Fasting Plasma Glucose (FPG)
Dietary fibre supplement (YMETA) → FIB-4 index
Dietary fibre supplement (YMETA) → FIB-4 index
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Diabetes Self-Management Education and Support (DSMES) Programs and HbA1c, High-Fiber Dietary Interventions and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies on Diabetes Self-Management Education and Support (DSMES) Programs
Contributes to Diabetes Self-Management Education and Support (DSMES) Programs evidence base.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies on High-Fiber Dietary Interventions
Contributes to High-Fiber Dietary Interventions evidence base.
Latest published studies
Published within the last 2 years.
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7 results
2 results
7 results
2 results
7 results
Generated from the study's connected evidence using Evidence Intelligence™.
Diabetes Self-Management Education and Support (DSMES) Programs may improve Body Mass Index.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
BMI
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 15 supporting studies with generally consistent results and a positive effect signal.
Limitations
High-Fiber Dietary Interventions appears to improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 3 supporting studies with consistent results and a positive effect signal.
Limitations
High-Fiber Dietary Interventions appears to improve Fasting Glucose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 3 supporting studies with consistent results and a positive effect signal.
Limitations
Dietary fibre supplement (YMETA) appears to improve FIB-4 index.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
FIB-4 index
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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