Last updated September 9, 2026
Key finding
Standard-of-care or early basal insulin therapy after KT did not influence HRQOL.
This study evaluated the impact of early postoperative basal insulin therapy on health-related quality of life after kidney transplantation, finding no significant influence on HRQOL.
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The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study evaluated the impact of early postoperative basal insulin therapy on health-related quality of life after kidney transplantation, finding no significant influence on HRQOL.
Understanding the impact of postoperative insulin therapy on quality of life is crucial for optimizing care in kidney transplant patients. While the study showed no significant difference in HRQOL between the two interventions, it highlighted the overall benefits of kidney transplantation on patients' physical and mental health, which can guide future treatment protocols.
The effectiveness of interventions was unclear due to lack of significant findings. The study may have limited generalizability due to specific population characteristics. Potential confounding factors were not fully addressed in the analysis.
Published in
Publication details and source links for this paper.
Balazs O, Matthias H, Elisabeth S, et al. Health-related quality of life after kidney transplantation: A randomized controlled trial on early postoperative basal insulin therapy. Transplant International. 2023;36:11370. doi:10.3389/ti.2023.11370
Kidney transplantation improved Physical Component Summary (PCS) scores at 6 months, which remained stable during follow-up.
Kidney transplantation improved Mental Component Summary (MCS) scores at 6 months, which remained stable during follow-up.
Neither early postoperative basal insulin therapy nor standard-of-care influenced health-related quality of life (HRQOL).
Evidence network
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This study contributes evidence to Insulin therapy and Health-related quality of life, Mental Component Summary (MCS) score, Quality of life (physical component).
This study contributes evidence to
Primary intervention
Insulin therapy
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
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2
Related topics
3
Evidence pairs
155
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Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
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Evidence topic
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Evidence topic
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Core evidence
The primary outcomes reported in this study.
Insulin therapy → Health-related quality of life
Insulin therapy → Health-related quality of life
Insulin therapy → Mental Component Summary (MCS) score
Insulin therapy → Mental Component Summary (MCS) score
Insulin therapy → Quality of life (physical component)
Insulin therapy → Quality of life (physical component)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Insulin Therapies and Quality of Life Outcomes, Insulin Therapies and Mental Component Summary (MCS) score.
This study contributes to the evidence on the following intervention-outcome relationships.
Medications
Curated evidence collections and hubs this study is part of.
All studies on Insulin Therapies
Contributes to Insulin Therapies evidence base.
All studies measuring Mental Component Summary (MCS) score
Measures Mental Component Summary (MCS) score as a key outcome.
All studies measuring Quality of Life Outcomes
Measures Quality of Life Outcomes as a key outcome.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Insulin Therapies may worsen quality of life outcomes or be associated with harm.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Health-related quality of life
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Insulin therapy appears to improve quality of life (physical component).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Quality of life (physical component)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Insulin therapy for mental component summary (MCS) score.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Mental Component Summary (MCS) score
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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