Last updated July 17, 2026
Key finding
E-TRE+DCR group had a day-night sensor ratio mean 0.27 units lower than DCR group at week 12.
This study examined the effects of Early Time-Restricted Eating combined with Daily Caloric Restriction on glucose levels in adults with overweight or obesity, finding a lower day-night sensor ratio in the E-TRE+DCR group.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study examined the effects of Early Time-Restricted Eating combined with Daily Caloric Restriction on glucose levels in adults with overweight or obesity, finding a lower day-night sensor ratio in the E-TRE+DCR group.
Understanding the effects of dietary patterns like Early Time-Restricted Eating is crucial for developing effective weight management strategies. While the reduction in the day-night sensor ratio suggests some metabolic benefits, the lack of differences in other glucose measures indicates that more research is needed to fully understand its impact on insulin sensitivity and glucose control.
Limited sample size may affect generalizability. Short duration of the study may not capture long-term effects. Lack of significant findings in most glucose measures.
Published in
Publication details and source links for this paper.
Rebecca J, Laura G, Sheila S, et al. Effects of Early Time-Restricted Eating on Glucose Profiles and Insulin Sensitivity in Adults with Overweight or Obesity. Journal of the Endocrine Society. 2022;6(Suppl 1):A9-A9. doi:10.1210/jendso/bvac150.018
E-TRE+DCR group had a day-night sensor ratio mean 0.27 units lower than DCR group at week 12.
No between-group differences in overall average sensor glucose.
No differences in minutes spent above 120 mg/dL between groups.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Time-Restricted Eating (TRE) and Coefficient of variation, Count of glucose excursions above 120 mg/dL, Difference in day-night sensor ratio between E-TRE+DCR and DCR groups at week 12, and 7 more.
This study contributes evidence to
Primary intervention
Time-Restricted Eating (TRE)
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
10
Evidence pairs
238
Related studies
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Time-Restricted Eating (TRE) → Coefficient of variation
Time-Restricted Eating (TRE) → Coefficient of variation
Time-Restricted Eating (TRE) → Count of glucose excursions above 120 mg/dL
Time-Restricted Eating (TRE) → Count of glucose excursions above 120 mg/dL
Time-Restricted Eating (TRE) → Difference in day-night sensor ratio between E-TRE+DCR and DCR groups at week 12
Time-Restricted Eating (TRE) → Difference in day-night sensor ratio between E-TRE+DCR and DCR groups at week 12
Time-Restricted Eating (TRE) → Fasting insulin levels
Time-Restricted Eating (TRE) → Fasting insulin levels
Time-Restricted Eating (TRE) → Fasting Plasma Glucose (FPG)
Time-Restricted Eating (TRE) → Fasting Plasma Glucose (FPG)
Time-Restricted Eating (TRE) → Insulin resistance
Time-Restricted Eating (TRE) → Insulin resistance
Time-Restricted Eating (TRE) → Mean amplitude of glycemic excursions (MAGE)
Time-Restricted Eating (TRE) → Mean amplitude of glycemic excursions (MAGE)
Time-Restricted Eating (TRE) → Mean sensor glucose
Time-Restricted Eating (TRE) → Mean sensor glucose
Time-Restricted Eating (TRE) → Minutes spent with glucose levels above 120 mg/dL
Time-Restricted Eating (TRE) → Minutes spent with glucose levels above 120 mg/dL
Time-Restricted Eating (TRE) → Standard deviation of glucose
Time-Restricted Eating (TRE) → Standard deviation of glucose
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Time-Restricted Eating (TRE) and Fasting Glucose, Time-Restricted Eating (TRE) and Insulin Resistance.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies measuring Insulin Resistance
Measures Insulin Resistance as a key outcome.
All studies on Time-Restricted Eating (TRE)
Contributes to Time-Restricted Eating (TRE) evidence base.
Jump to pre-filtered views in Evidence Explorer.
2 results
2 results
2 results
2 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Time-Restricted Eating (TRE) may improve Fasting Plasma Glucose (FPG).
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Time-Restricted Eating (TRE) may improve Insulin resistance.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Insulin resistance
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Current evidence does not show a clear benefit of Time-Restricted Eating (TRE) for Coefficient of variation.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Coefficient of variation
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Time-Restricted Eating (TRE) for Count of glucose excursions above 120 mg/dL.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Count of glucose excursions above 120 mg/dL
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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