Research Summary

Analyzed using Evidence Intelligence™

Time-Restricted Eating Shows No Effect on Mood or Quality of Life in Diabetes

Last updated July 17, 2026

Key finding

Body weight significantly decreased in the TRE group (−3.38%; 95% CI, −6.04 to −0.71%, p = 0.008)

This study examined the effects of time-restricted eating on mood and quality of life in adults with type 2 diabetes, finding significant weight loss in the TRE group.

Quick read

Study at a glance

The essential study design details in one scan.

EvidenceScore™

Moderate

Study type

RCTs

Follow-up

Medium-Term (3–12 mo)

Risk of bias

High Risk

Save research, organize studies, and quickly find important evidence again.

Plain-language summary

What this paper says

A plain-language read of the study’s main message and where it applies.

Study focus

This study examined the effects of time-restricted eating on mood and quality of life in adults with type 2 diabetes, finding significant weight loss in the TRE group.

Clinical relevance

These findings suggest that time-restricted eating may be an effective dietary strategy for weight management in adults with type 2 diabetes, potentially improving overall health outcomes. Understanding the impact of different dietary interventions can help clinicians tailor recommendations for patients seeking to manage their diabetes effectively.

Keep in mind

The study did not measure long-term effects beyond six months. Sample size and demographic diversity may limit generalizability. No significant changes were observed in mood or fat mass.

Published in

Journal Reference

Publication details and source links for this paper.

Vasiliki P, Shuhao L, Sofia C, et al. Effects of Time-Restricted Eating on Mood and Quality of Life in Adults with Type 2 Diabetes: A Secondary Analysis. Nutrients. 2025;17(17):2757. doi:10.3390/nu17172757

View DOI View on PubMed View on PMC

Main Effects

Body weight significantly decreased in the TRE group (−3.38%; p = 0.008).

Body weight did not significantly change in the CR group (−1.80%; p = 0.32).

Fat mass and lean mass remained unchanged in both TRE and CR groups compared to controls.

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to Calorie restriction, Time-Restricted Eating (TRE) and Body fat mass, Body weight, Depression score, and 3 more.

This study contributes evidence to

Intervention

Calorie restriction

Outcome

Body fat mass

Evidence topic

Dietary Patterns

Primary intervention

Calorie restriction

Primary outcomes

Body fat mass
Body weight
Depression score

Evidence topics

Dietary Patterns Weight Loss

Primary intervention

Calorie restriction

Primary outcomes

Body fat mass Body weight Depression score

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

Evidence pairs

Relationships

Evidence topics

contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 69

Why it is useful

Contributes to 12 evidence relationships
Includes primary outcome data
Linked to 2 direct semantic evidence topics

Topic contributions

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

Add related evidence to your Evidence Tracker

Save studies and evidence pages, organize your personal Evidence Tracker, and keep the research you care about in one place.

Primary evidence

Evidence topic

Dietary Patterns

matched_intervention_and_outcome

Related evidence

Evidence topic

Weight Loss

Save evidence

Core evidence

Study findings

The primary outcomes reported in this study.

Body fat mass

Calorie restriction → Body fat mass

Evidence Intelligence™

EvidenceScore™: Moderate; Score 69 · Based on 2 studies
ImpactScore™: 75; Positive
ConsistencyScore™: 35; mixed

Based on 2 studies

Add to Evidence Tracker

Body weight

Calorie restriction → Body weight

Evidence Intelligence™

EvidenceScore™: 82; Strong
ImpactScore™: 70; Positive
ConsistencyScore™: 60; generally_consistent

Based on 5 studies

Add to Evidence Tracker

Depression score

Calorie restriction → Depression score

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Lean body mass

Calorie restriction → Lean body mass

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Quality of life

Calorie restriction → Quality of life

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Total mood disturbance score change

Calorie restriction → Total mood disturbance score change

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Body fat mass

Time-Restricted Eating (TRE) → Body fat mass

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Body weight

Time-Restricted Eating (TRE) → Body weight

Evidence Intelligence™

EvidenceScore™: 79; Strong
ImpactScore™: 100; Very Positive
ConsistencyScore™: 100; consistent

Based on 3 studies

Add to Evidence Tracker

Depression score

Time-Restricted Eating (TRE) → Depression score

Evidence Intelligence™

EvidenceScore™: Moderate; Score 69 · Based on 2 studies
ImpactScore™: 50; Neutral
ConsistencyScore™: 100; consistent

Based on 2 studies

Add to Evidence Tracker

Lean body mass

Time-Restricted Eating (TRE) → Lean body mass

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Quality of life

Time-Restricted Eating (TRE) → Quality of life

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Total mood disturbance score change

Time-Restricted Eating (TRE) → Total mood disturbance score change

Evidence Intelligence™

EvidenceScore™: Emerging; Score 59 · Based on 1 study
ImpactScore™: 50; Neutral
ConsistencyScore™: unclear; Not enough independent studies

Based on 1 study

Add to Evidence Tracker

Evidence Library

Build your evidence library

Save research, organize studies, and quickly find important evidence again.

Evidence Suggest

TRE led to a significant weight loss of 3.38% (p = 0.008).
CR showed no significant weight change (−1.80%, p = 0.32).
Mood scores remained stable across TRE and CR groups.

Who this applies to

Adults aged 18-65 with type 2 diabetes.
Individuals seeking dietary interventions for weight management.

Keep in Mind

Results may not apply to populations outside the study's demographic.
Short study duration limits understanding of long-term effects.
No significant impact on mood or fat mass was observed.

Between the Lines

The study did not measure long-term effects beyond six months.
Sample size and demographic diversity may limit generalizability.
No significant changes were observed in mood or fat mass.

Evidence Library

Build your evidence library

Save research, organize studies, and quickly find important evidence again.

Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

This study contributes to evidence on Calorie restriction and Body Weight, Time-Restricted Eating (TRE) and Body Weight.

Related evidence relationships

Explore in Evidence Explorer

This study contributes to the evidence on the following intervention-outcome relationships.

Diet and Nutrition

Detailed evidence

Calorie restriction → Body Weight

Diet and Nutrition

Evidence Intelligence™

EvidenceScore™: 82; Strong
ImpactScore™: 70; Positive
ConsistencyScore™: 60; generally_consistent

Based on 5 studies

View evidence

Diet and Nutrition

Detailed evidence

Time-Restricted Eating (TRE) → Body Weight

Diet and Nutrition

Evidence Intelligence™

EvidenceScore™: 79; Strong
ImpactScore™: 100; Very Positive
ConsistencyScore™: 100; consistent

Based on 3 studies

View evidence

Diet and Nutrition

Detailed evidence

Calorie restriction → Body Composition

Diet and Nutrition

Evidence Intelligence™

EvidenceScore™: Moderate; Score 69 · Based on 2 studies
ImpactScore™: 75; Positive
ConsistencyScore™: 35; mixed

Based on 2 studies

View evidence

Included in these evidence collections

Curated evidence collections and hubs this study is part of.

Body Weight Evidence Hub

All studies measuring Body Weight

5 studies

outcome_hub

Measures Body Weight as a key outcome.

Calorie restriction Evidence Hub

All studies on Calorie restriction

5 studies

intervention_hub

Contributes to Calorie restriction evidence base.

Time-Restricted Eating (TRE) Evidence Hub

All studies on Time-Restricted Eating (TRE)

3 studies

intervention_hub

Contributes to Time-Restricted Eating (TRE) evidence base.

Body Composition Evidence Hub

All studies measuring Body Composition

2 studies

outcome_hub

Measures Body Composition as a key outcome.

Recent Diabetes Research

Latest published studies

recency_collection

Published within the last 2 years.

Explore more in Evidence Explorer

Jump to pre-filtered views in Evidence Explorer.

All studies on Calorie restriction and Body weight

Intervention: Calorie restrictionOutcome: Body weight

5 results

All studies on Time-Restricted Eating (TRE) and Body weight

Intervention: Time-Restricted Eating (TRE)Outcome: Body weight

3 results

All studies on Calorie restriction

Intervention: Calorie restriction

5 results

All studies on Time-Restricted Eating (TRE)

Intervention: Time-Restricted Eating (TRE)

3 results

All studies measuring Body weight

Outcome: Body weight

5 results

Questions answered by this study

Generated from the study's connected evidence using Evidence Intelligence™.

Does Calorie restriction affect body weight?

Strong Evidence

Calorie restriction may improve Body weight.

ConsistencyScore™: Results are generally consistent across studies.

Ranked evidence signals

1
Body weight
EvidenceScore™ Strong | EvidenceScore™ 81.5 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Population details are unavailable.

View Full Evidence

Does Time-Restricted Eating (TRE) affect body weight?

Strong Evidence

Time-Restricted Eating (TRE) appears to improve Body weight.

ConsistencyScore™: Results are consistent across studies.

Ranked evidence signals

1
Body weight
EvidenceScore™ Strong | EvidenceScore™ 78.7 | strong positive | ConsistencyScore™ Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Population details are unavailable.

View Full Evidence

Does Calorie restriction improve body fat mass?

Moderate Evidence

Calorie restriction may improve Body fat mass.

ConsistencyScore™: Results are mixed and should be interpreted cautiously.

Evidence caveat: The available evidence reports mixed findings.

Ranked evidence signals

1
Body fat mass
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study

Why this answer: This answer is cautious because the available studies report mixed findings.

Limitations

Only one supporting study is available.
Population details are unavailable.

View Full Evidence

Does Time-Restricted Eating (TRE) improve depression score?

Moderate Evidence

Current evidence does not show a clear benefit of Time-Restricted Eating (TRE) for Depression score.

ConsistencyScore™: Results are consistent across studies.

Ranked evidence signals

1
Depression score
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Population details are unavailable.

View Full Evidence

Learn how Evidence Intelligence™ works

Next steps

Continue your research

Choose a next path through related evidence topics, Evidence Explorer views, and research summaries.

Evidence topics

Follow the topics this study contributes to.

Dietary Patterns Evidence Hub Weight Loss Evidence Hub

Explore in Evidence Explorer

Open broader Evidence Explorer views for this relationship.

All studies on Calorie restriction and Body weight All studies on Time-Restricted Eating (TRE) and Body weight All studies on Calorie restriction and Body fat mass All studies on Time-Restricted Eating (TRE) and Depression score

Related research

Read related research summaries.

Time-restricted eating may improve adherence in type 2 diabetes Time-restricted feeding improves blood glucose and weight in type 2 diabetes Early time-restricted eating may improve glucose profiles in adults with obesity MIND diet improves cardiometabolic health in women with diabetes Structured exercise improves weight loss after gastric bypass surgery

No ads. No tracking.

Focused on evidence, not advertising.

Secure & private

Your data is always protected.

Always up to date

New studies added every day.