Last updated July 18, 2026
Key finding
Mean total body weight loss was 15.9% at 36 months.
This study evaluated the outcomes of endoscopic partial jejunal diversion using a self-assembling magnetic anastomosis system over 36 months, finding significant weight loss and improvements in glycemic control.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the outcomes of endoscopic partial jejunal diversion using a self-assembling magnetic anastomosis system over 36 months, finding significant weight loss and improvements in glycemic control.
These findings highlight the potential of endoscopic partial jejunal diversion as a safe and effective intervention for significant weight loss and improved diabetes management in patients who may not respond to traditional weight loss methods. This could provide a new avenue for treatment in obesity and metabolic disorders.
Single-arm study design limits comparison to control groups. Long-term effects beyond 36 months are unknown. Limited generalizability due to specific population characteristics.
Published in
Publication details and source links for this paper.
Marek B, Evžen M, Marvin R, et al. Endoscopic Partial Jejunal Diversion Using a Self-Assembling Magnetic Anastomosis System: 36-Month Outcomes. Endoscopy International Open. 2026;14:a28927821. doi:10.1055/a-2892-7821
Mean total body weight loss of 15.9% at 36 months.
Mean excess weight loss of 43.2% at 36 months.
Mean HbA1c decreased by 1.8 percentage points in diabetic patients.
Mean HbA1c decreased by 1.1 percentage points in prediabetic patients.
Evidence network
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This study contributes evidence to Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) and Adverse events incidence, Body weight, HbA1c, and 2 more.
This study contributes evidence to
Primary intervention
Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS)
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
5
Evidence pairs
487
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
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Core evidence
The primary outcomes reported in this study.
Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) → Adverse events incidence
Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) → Adverse events incidence
Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) → Body weight
Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) → Body weight
Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) → HbA1c
Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) → HbA1c
Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) → Mean Excess Weight Loss at 36 Months
Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) → Mean Excess Weight Loss at 36 Months
Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) → Serious adverse events
Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) → Serious adverse events
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) and Adverse events incidence, Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) and Body Weight.
This study contributes to the evidence on the following intervention-outcome relationships.
Procedures
Curated evidence collections and hubs this study is part of.
All studies measuring Adverse events incidence
Measures Adverse events incidence as a key outcome.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
All studies on Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS)
Contributes to Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) evidence base.
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Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) appears to improve Body weight.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Body weight
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) appears to improve HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) appears to improve Mean Excess Weight Loss at 36 Months.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Mean Excess Weight Loss at 36 Months
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Partial Jejunal Diversion (PJD) using Incisionless Magnetic Anastomosis System (IMAS) for Adverse events incidence.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Adverse events incidence
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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