Last updated September 12, 2026
Key finding
Post exercise, the CHRFAM7A increased in AE for HNW.
This study investigated the effects of different exercise types on gene expression in individuals with Type 2 Diabetes, finding increased CHRFAM7A expression post-exercise.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study investigated the effects of different exercise types on gene expression in individuals with Type 2 Diabetes, finding increased CHRFAM7A expression post-exercise.
Understanding how exercise influences gene expression can help tailor physical activity recommendations for individuals with Type 2 Diabetes. This could lead to improved management of the disease and better health outcomes.
The effectiveness of the interventions remains unclear due to lack of detailed outcomes. No significant differences were found for TNF-α and CHRNA7 gene expressions. The sample size and demographic details were not specified.
Published in
Publication details and source links for this paper.
Keryma CDSM, Ivan LPB, Amanda VS, et al. Effects of Different Types of Exercises on Gene Expression in Individuals with Type 2 Diabetes. Biomedicines. 2023;11(2):565. doi:10.3390/biomedicines11020565
CHRFAM7A gene expression increased post-exercise in the aerobic group.
CHRFAM7A gene expression increased post-exercise in the resistance group.
CHRFAM7A gene expression increased post-exercise in the combined exercise group.
Evidence network
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This study contributes evidence to Aerobic exercise, Mixed exercise, Taichi plus resistance band training and NLRP3 gene expression, REV-ERBα gene expression.
This study contributes evidence to
Primary intervention
Aerobic exercise
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
6
Evidence pairs
50
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_intervention
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Aerobic exercise → NLRP3 gene expression
Aerobic exercise → NLRP3 gene expression
Aerobic exercise → REV-ERBα gene expression
Aerobic exercise → REV-ERBα gene expression
Mixed exercise → REV-ERBα gene expression
Mixed exercise → REV-ERBα gene expression
Taichi plus resistance band training → NLRP3 gene expression
Taichi plus resistance band training → NLRP3 gene expression
Taichi plus resistance band training → REV-ERBα gene expression
Taichi plus resistance band training → REV-ERBα gene expression
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Aerobic Exercise and REV-ERBα gene expression, Aerobic Exercise and NLRP3 gene expression.
This study contributes to the evidence on the following intervention-outcome relationships.
Physical Activity
Physical Activity
Curated evidence collections and hubs this study is part of.
All studies on Aerobic Exercise
Contributes to Aerobic Exercise evidence base.
All studies measuring REV-ERBα gene expression
Measures REV-ERBα gene expression as a key outcome.
All studies measuring NLRP3 gene expression
Measures NLRP3 gene expression as a key outcome.
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2 results
1 results
2 results
2 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Aerobic exercise appears to improve rev-erbα gene expression.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
REV-ERBα gene expression
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Mixed exercise appears to improve rev-erbα gene expression.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
REV-ERBα gene expression
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Taichi plus resistance band training appears to improve rev-erbα gene expression.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
REV-ERBα gene expression
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Aerobic exercise for nlrp3 gene expression.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
NLRP3 gene expression
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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