StrongDecrease
Abundance of Colidextribacter
Fish oil → Abundance of Colidextribacter
Fish oil → Abundance of Colidextribacter
Evidence profile
StrongDecreaseMetabolic Health
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Research Summary
Analyzed using Evidence Intelligence™
Fish oil improves lipid profiles in type 2 diabetes patients
Key finding
Serum fasting blood glucose (p = 0.039) was significantly lower in the fish oil intervention group than in the corn oil control group at three months.
This study examined the effects of fish oil-derived omega-3 fatty acids on gut microbiota and serum lipid metabolites in individuals with Type 2 Diabetes Mellitus (T2DM). The fish oil group showed significant improvements in various metabolic markers compared to the corn oil control group.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Extended (5–20+ y)
Some Concerns bias
Last updated July 2, 2026Quick read
Study at a glance
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Fish oil
Study type
RCTs
Follow-up
Extended (5–20+ y)
Primary outcome
Fasting Plasma Glucose (FPG)
Comparator
Corn Oil Group
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
This study examined the effects of fish oil-derived omega-3 fatty acids on gut microbiota and serum lipid metabolites in individuals with Type 2 Diabetes Mellitus (T2DM). The fish oil group showed significant improvements in various metabolic markers compared to the corn oil control group.
Clinical relevance
These findings highlight the potential of fish oil-derived omega-3 fatty acids as a therapeutic option for improving metabolic health in individuals with T2DM. By reducing fasting blood glucose and improving lipid profiles, omega-3 supplementation may contribute to better diabetes management and reduce the risk of cardiovascular complications associated with the disease.
Keep in mind
The study was limited to a specific population with T2DM, which may affect generalizability. The duration of the intervention was relatively short at three months. Potential confounding factors were not fully explored.
Published in
Journal Reference
Publication details and source links for this paper.
Jiayue X, Shiyu Y, Junhui Y, et al. Effects of Fish Oil-Derived Omega-3 Fatty Acids on Gut Microbiota and Serum Lipid Metabolites in T2DM. Nutrients. 2024;16(21):3755. doi:10.3390/nu16213755
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Main Effects
Serum fasting blood glucose was significantly lower in the fish oil group (p = 0.039).
Glycosylated hemoglobin levels were significantly reduced in the fish oil group (p = 0.048).
Total cholesterol levels were significantly lower in the fish oil group (p < 0.001).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Fish oil and Abundance of Colidextribacter, Abundance of Desulfobacterota, Abundance of Haemophilus, and 12 more.
This study contributes evidence to
Primary intervention
Fish oil
Primary outcomes
- Abundance of Colidextribacter
- Abundance of Desulfobacterota
- Abundance of Haemophilus
Evidence topics
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
15
Evidence pairs
15
Relationships
2
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 64
2
Related topics
15
Evidence pairs
270
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 15 evidence relationships
- Includes primary outcome data
- Linked to 2 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
Study findings
The primary outcomes reported in this study.
StrongDecrease
Abundance of Desulfobacterota
Fish oil → Abundance of Desulfobacterota
Fish oil → Abundance of Desulfobacterota
Evidence profile
StrongDecreaseMetabolic Health
Unlock full evidence details
StrongIncrease
Abundance of Haemophilus
Fish oil → Abundance of Haemophilus
Fish oil → Abundance of Haemophilus
Evidence profile
StrongIncreaseMetabolic Health
Unlock full evidence details
StrongDecrease
Abundance of Klebsiella
Fish oil → Abundance of Klebsiella
Fish oil → Abundance of Klebsiella
Evidence profile
StrongDecreaseMetabolic Health
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StrongIncrease
Abundance of Lactobacillus
Fish oil → Abundance of Lactobacillus
Fish oil → Abundance of Lactobacillus
Evidence profile
StrongIncreaseMetabolic Health
Unlock full evidence details
StrongIncrease
Abundance of Limosilactobacillus
Fish oil → Abundance of Limosilactobacillus
Fish oil → Abundance of Limosilactobacillus
Evidence profile
StrongIncreaseMetabolic Health
Unlock full evidence details
StrongDecrease
Abundance of Ralstonia
Fish oil → Abundance of Ralstonia
Fish oil → Abundance of Ralstonia
Evidence profile
StrongDecreaseMetabolic Health
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StrongDecrease
Fasting blood sugar (FBS)
Fish oil → Fasting blood sugar (FBS)
Fish oil → Fasting blood sugar (FBS)
Evidence profile
StrongDecreaseGlycemic Control
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NoneNo Change
Fasting Plasma Glucose (FPG)
Fish oil → Fasting Plasma Glucose (FPG)
Fish oil → Fasting Plasma Glucose (FPG)
Evidence profile
NoneNo ChangeGlycemic Control
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StrongDecrease
HbA1c
Fish oil → HbA1c
Fish oil → HbA1c
Evidence profile
StrongDecreaseGlycemic Control
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HarmfulDecrease
HDL cholesterol
Fish oil → HDL cholesterol
Fish oil → HDL cholesterol
Evidence profile
HarmfulDecreaseMetabolic Health
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StrongDecrease
Insulin resistance
Fish oil → Insulin resistance
Fish oil → Insulin resistance
Evidence profile
StrongDecreaseMetabolic Health
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StrongDecrease
LDL cholesterol
Fish oil → LDL cholesterol
Fish oil → LDL cholesterol
Evidence profile
StrongDecreaseMetabolic Health
Unlock full evidence details
StrongDecrease
Total cholesterol
Fish oil → Total cholesterol
Fish oil → Total cholesterol
Evidence profile
StrongDecreaseMetabolic Health
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StrongDecrease
Triglycerides
Fish oil → Triglycerides
Fish oil → Triglycerides
Evidence profile
StrongDecreaseMetabolic Health
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Evidence Suggest
- Fish oil reduced triglycerides by -0.5 mmol/L (p = 0.001).
- LDL cholesterol was significantly lower in the fish oil group (p = 0.048).
- The abundance of Desulfobacterota was significantly lower in the fish oil group (p = 0.003).
Who this applies to
- Adults diagnosed with Type 2 Diabetes Mellitus.
- Individuals looking for dietary interventions to improve metabolic health.
Keep in Mind
- Results may not apply to populations without diabetes.
- The study did not assess long-term effects beyond three months.
- Further research is needed to explore the mechanisms behind observed changes.
Between the Lines
- The study was limited to a specific population with T2DM, which may affect generalizability.
- The duration of the intervention was relatively short at three months.
- Potential confounding factors were not fully explored.
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Fish oil and Abundance of Colidextribacter, Fish oil and Abundance of Desulfobacterota.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
Abundance of Colidextribacter Evidence Hub
All studies measuring Abundance of Colidextribacter
1 studies
outcome_hubMeasures Abundance of Colidextribacter as a key outcome.
Abundance of Desulfobacterota Evidence Hub
All studies measuring Abundance of Desulfobacterota
1 studies
outcome_hubMeasures Abundance of Desulfobacterota as a key outcome.
Adipokine and Angiogenic Markers Evidence Hub
All studies measuring Adipokine and Angiogenic Markers
1 studies
outcome_hubMeasures Adipokine and Angiogenic Markers as a key outcome.
Fish oil Evidence Hub
All studies on Fish oil
1 studies
intervention_hubContributes to Fish oil evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Fish oil and Abundance of Colidextribacter
Intervention: Fish oilOutcome: Abundance of Colidextribacter
1 results
All studies on Fish oil and Abundance of Desulfobacterota
Intervention: Fish oilOutcome: Abundance of Desulfobacterota
1 results
All studies on Fish oil
Intervention: Fish oil
1 results
All studies measuring Abundance of Colidextribacter
Outcome: Abundance of Colidextribacter
1 results
All studies measuring Abundance of Desulfobacterota
Outcome: Abundance of Desulfobacterota
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Fish oil improve abundance of colidextribacter?
Emerging Evidence
Fish oil appears to improve Abundance of Colidextribacter.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Abundance of Colidextribacter
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Fish oil improve abundance of desulfobacterota?
Emerging Evidence
Fish oil appears to improve Abundance of Desulfobacterota.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Abundance of Desulfobacterota
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Fish oil improve abundance of haemophilus?
Emerging Evidence
Fish oil appears to improve Abundance of Haemophilus.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Abundance of Haemophilus
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Fish oil improve abundance of klebsiella?
Emerging Evidence
Fish oil appears to improve Abundance of Klebsiella.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Abundance of Klebsiella
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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