Last updated July 18, 2026
Key finding
Response rate in the glycated hemoglobin group was 29.2% (CI 27.6–30.8) versus 24.6% (CI 23.1–26.1) in the OGTT group (p = 0.0002).
This study compared the effectiveness of glycated hemoglobin measurement and oral glucose tolerance test for screening in South Asian individuals, finding higher response and participation rates for the former.
Quick read
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EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study compared the effectiveness of glycated hemoglobin measurement and oral glucose tolerance test for screening in South Asian individuals, finding higher response and participation rates for the former.
These findings are significant for public health strategies aimed at improving diabetes screening in South Asian populations, who are at higher risk for diabetes. By identifying a more effective screening method, healthcare providers can enhance participation rates, potentially leading to earlier diagnosis and better management of diabetes in this demographic.
The study design was non-randomized, which may introduce bias. Results may not be generalizable beyond South Asian populations. Potential confounding factors were not fully controlled.
Published in
Publication details and source links for this paper.
Irene GMVV, Everlina MAV, Vera N, Barend JCM, Karien S, Alberico C. Direct comparisons of the effect of a glycated haemoglobin measurement or an oral glucose tolerance test on the uptake and yield of screening in people of South Asian origin have not been made. PLOS ONE. 2015;10(8):e0136734. doi:10.1371/journal.pone.0136734
Glycated hemoglobin group had a response rate of 29.2% compared to 24.6% in the OGTT group (p = 0.0002).
Participation rate was significantly higher in the glycated hemoglobin group at 23.9% versus 19.3% in the OGTT group (p<0.0001).
The adjusted odds ratio for response was 1.30 for the glycated hemoglobin group compared to 1.00 for the OGTT group.
Evidence network
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This study contributes evidence to Glycated Hemoglobin Screening, Oral glucose tolerance test and Odds ratio for response in glycated hemoglobin screening, Participation rate in glycated hemoglobin screening, Response rate.
This study contributes evidence to
Primary intervention
Glycated Hemoglobin Screening
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
6
Evidence pairs
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Related studies
Core evidence
The primary outcomes reported in this study.
Glycated Hemoglobin Screening → Odds ratio for response in glycated hemoglobin screening
Glycated Hemoglobin Screening → Odds ratio for response in glycated hemoglobin screening
Glycated Hemoglobin Screening → Participation rate in glycated hemoglobin screening
Glycated Hemoglobin Screening → Participation rate in glycated hemoglobin screening
Glycated Hemoglobin Screening → Response rate
Glycated Hemoglobin Screening → Response rate
Oral glucose tolerance test → Odds ratio for response in glycated hemoglobin screening
Oral glucose tolerance test → Odds ratio for response in glycated hemoglobin screening
Oral glucose tolerance test → Participation rate in glycated hemoglobin screening
Oral glucose tolerance test → Participation rate in glycated hemoglobin screening
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This study contributes to evidence on Glycated Hemoglobin Screening and Odds ratio for response in glycated hemoglobin screening, Glycated Hemoglobin Screening and Participation rate in glycated hemoglobin screening.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies on Glycated Hemoglobin Screening
Contributes to Glycated Hemoglobin Screening evidence base.
All studies measuring Odds ratio for response in glycated hemoglobin screening
Measures Odds ratio for response in glycated hemoglobin screening as a key outcome.
All studies measuring Participation rate in glycated hemoglobin screening
Measures Participation rate in glycated hemoglobin screening as a key outcome.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Glycated Hemoglobin Screening appears to improve Odds ratio for response in glycated hemoglobin screening.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Odds ratio for response in glycated hemoglobin screening
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Glycated Hemoglobin Screening appears to improve Participation rate in glycated hemoglobin screening.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Participation rate in glycated hemoglobin screening
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Glycated Hemoglobin Screening appears to improve Response rate.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Response rate
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Oral glucose tolerance test appears to improve Participation rate in glycated hemoglobin screening.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Participation rate in glycated hemoglobin screening
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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