StrongIncrease
Adiponectin
Green tea extract → Adiponectin
Green tea extract → Adiponectin
Evidence profile
StrongIncreaseMetabolic Health
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Research Summary
Analyzed using Evidence Intelligence™
Green tea extract may improve insulin resistance in type 2 diabetes patients
Key finding
Triglyceride decreased significantly from baseline.
This study evaluated the impact of green tea extract on glycemic and lipid profiles in patients with type 2 diabetes, finding significant improvements in several metabolic markers.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Some Concerns bias
Last updated July 5, 2026Quick read
Study at a glance
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Green tea extract, Placebo (cellulose)
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Primary outcome
Triglyceride
Comparator
Placebo
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
This study evaluated the impact of green tea extract on glycemic and lipid profiles in patients with type 2 diabetes, finding significant improvements in several metabolic markers.
Clinical relevance
The findings suggest that green tea extract could be a beneficial adjunct therapy for patients with type 2 diabetes, potentially aiding in the management of lipid levels and insulin resistance. This could lead to improved overall health outcomes and reduced risk of diabetes-related complications.
Keep in mind
The sample size and demographic diversity were not specified. The study did not assess long-term effects of green tea extract. Results may not be generalizable to all populations with type 2 diabetes.
Published in
Journal Reference
Publication details and source links for this paper.
Chia-Yu L, Chien-Jung H, Lin-Huang H, et al. The Effect of Green Tea Extract on Glycemic and Lipid Profiles in Patients with Type 2 Diabetes: A Randomized, Double-Blinded, Placebo-Controlled Trial. PLoS ONE. 2014;9(3):e91163. doi:10.1371/journal.pone.0091163
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Main Effects
Triglycerides decreased significantly by 18.9 mg/dL in the green tea extract group.
HOMA-IR decreased from 5.4±3.9 to 3.5±2.0 in the therapeutic arm.
HDL-C increased significantly by 2.7 mg/dL in the green tea extract group.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Green tea extract and Adiponectin, Apolipoprotein A1, Apolipoprotein B100, and 4 more.
This study contributes evidence to
Primary intervention
Green tea extract
Primary outcomes
- Adiponectin
- Apolipoprotein A1
- Apolipoprotein B100
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
7
Evidence pairs
7
Relationships
0
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 50
0
Related topics
7
Evidence pairs
0
Related studies
Why it is useful
- Contributes to 7 evidence relationships
- Includes primary outcome data
- Linked to 0 direct semantic evidence topics
Core evidence
Study findings
The primary outcomes reported in this study.
StrongIncrease
Apolipoprotein A1
Green tea extract → Apolipoprotein A1
Green tea extract → Apolipoprotein A1
Evidence profile
StrongIncreaseClinical Outcomes
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StrongIncrease
Apolipoprotein B100
Green tea extract → Apolipoprotein B100
Green tea extract → Apolipoprotein B100
Evidence profile
StrongIncreaseClinical Outcomes
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StrongIncrease
GLP-1
Green tea extract → GLP-1
Green tea extract → GLP-1
Evidence profile
StrongIncreaseMetabolic Health
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StrongIncrease
HDL cholesterol
Green tea extract → HDL cholesterol
Green tea extract → HDL cholesterol
Evidence profile
StrongIncreaseMetabolic Health
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StrongDecrease
Insulin resistance
Green tea extract → Insulin resistance
Green tea extract → Insulin resistance
Evidence profile
StrongDecreaseMetabolic Health
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StrongDecrease
Triglycerides
Green tea extract → Triglycerides
Green tea extract → Triglycerides
Evidence profile
StrongDecreaseMetabolic Health
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Unlock full evidence analysis
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Evidence Suggest
- Green tea extract led to a significant decrease in triglycerides.
- HOMA-IR improved significantly in the therapeutic group.
- HDL-C levels increased notably in patients taking green tea extract.
Who this applies to
- Adults diagnosed with type 2 diabetes.
- Patients looking for adjunct therapies to manage diabetes.
Keep in Mind
- The study's findings are based on a specific population and may not apply universally.
- Further research is needed to confirm long-term benefits and safety.
- The placebo group did not show significant changes, indicating the need for careful interpretation of results.
Between the Lines
- The sample size and demographic diversity were not specified.
- The study did not assess long-term effects of green tea extract.
- Results may not be generalizable to all populations with type 2 diabetes.
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Green tea extract and Adipokine and Angiogenic Markers, Green tea extract and Apolipoprotein A1.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
Adipokine and Angiogenic Markers Evidence Hub
All studies measuring Adipokine and Angiogenic Markers
1 studies
outcome_hubMeasures Adipokine and Angiogenic Markers as a key outcome.
Apolipoprotein A1 Evidence Hub
All studies measuring Apolipoprotein A1
1 studies
outcome_hubMeasures Apolipoprotein A1 as a key outcome.
Green tea extract Evidence Hub
All studies on Green tea extract
1 studies
intervention_hubContributes to Green tea extract evidence base.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Green tea extract and Adiponectin
Intervention: Green tea extractOutcome: Adiponectin
1 results
All studies on Green tea extract and Apolipoprotein A1
Intervention: Green tea extractOutcome: Apolipoprotein A1
1 results
All studies on Green tea extract
Intervention: Green tea extract
1 results
All studies measuring Adiponectin
Outcome: Adiponectin
1 results
All studies measuring Apolipoprotein A1
Outcome: Apolipoprotein A1
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Green tea extract improve adiponectin?
Emerging Evidence
Green tea extract appears to improve Adiponectin.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Adiponectin
EvidenceScore™ Emerging | EvidenceScore™ 51.7 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Green tea extract improve apolipoprotein a1?
Emerging Evidence
Green tea extract appears to improve Apolipoprotein A1.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Apolipoprotein A1
EvidenceScore™ Emerging | EvidenceScore™ 51.7 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Green tea extract improve apolipoprotein b100?
Emerging Evidence
Green tea extract appears to improve Apolipoprotein B100.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Apolipoprotein B100
EvidenceScore™ Emerging | EvidenceScore™ 51.7 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Green tea extract improve glp-1?
Emerging Evidence
Green tea extract appears to improve GLP-1.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
GLP-1
EvidenceScore™ Emerging | EvidenceScore™ 51.7 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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