Last updated July 18, 2026
Key finding
73.33% patients in the prediabetes subgroup returned to normoglycemia.
This study evaluated the impact of hypoglycemic agents combined with a high protein diet and moderate exercise on diabetes remission rates.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the impact of hypoglycemic agents combined with a high protein diet and moderate exercise on diabetes remission rates.
These findings highlight the potential for a combined approach of medication, diet, and exercise in achieving diabetes remission. This could lead to better management strategies for patients with diabetes and prediabetes, ultimately reducing the burden of diabetes-related complications.
The study's sample size may limit generalizability. Effectiveness of interventions may vary in broader populations. Long-term effects of the interventions were not assessed.
Published in
Publication details and source links for this paper.
Shi Z, Yi W, Xincheng W, et al. Hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise could lead to a considerable proportion of patients with diabetes achieving diabetes remission. BMC Medicine. 2025;23:270. doi:10.1186/s12916-025-04072-4
86.67% of diabetes patients achieved remission in the intensive treatment group.
Mean weight change was -19.29 kg in the intensive treatment group.
Significant reduction in body fat percentage in the intensive treatment group (P < 0.001).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Intensive treatment group, Standard treatment group and Body fat percentage reduction, Controlled attenuation parameter, Diabetes remission, and 2 more.
This study contributes evidence to
Primary intervention
Intensive treatment group
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
6
Evidence pairs
189
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Intensive treatment group → Body fat percentage reduction
Intensive treatment group → Body fat percentage reduction
Intensive treatment group → Controlled attenuation parameter
Intensive treatment group → Controlled attenuation parameter
Intensive treatment group → Diabetes remission
Intensive treatment group → Diabetes remission
Intensive treatment group → Visceral adipose tissue area
Intensive treatment group → Visceral adipose tissue area
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Intensive treatment group and Body Composition, Intensive treatment group and Controlled attenuation parameter.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring Body Composition
Measures Body Composition as a key outcome.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
All studies measuring Controlled attenuation parameter
Measures Controlled attenuation parameter as a key outcome.
All studies on Intensive treatment group
Contributes to Intensive treatment group evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Intensive treatment group appears to improve Body fat percentage reduction.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Body fat percentage reduction
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Intensive treatment group appears to improve Controlled attenuation parameter.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Controlled attenuation parameter
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Intensive treatment group appears to improve Diabetes remission.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Diabetes remission
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Intensive treatment group appears to improve Visceral adipose tissue area.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Visceral adipose tissue area
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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