Last updated August 22, 2026
Key finding
No effects of the intervention on IR were observed.
The PREVIEW study investigated the effects of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/obesity, finding no significant effects.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
The PREVIEW study investigated the effects of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/obesity, finding no significant effects.
Understanding the effectiveness of dietary interventions in managing insulin resistance is crucial for developing strategies to combat obesity and related health issues in adolescents. The lack of observed effects suggests that simply changing diet composition may not be sufficient to improve insulin sensitivity in this population, highlighting the need for further research and possibly more comprehensive lifestyle interventions.
The study had a low retention rate of 39%, which may affect the reliability of the results. No significant changes in insulin resistance were observed, indicating potential ineffectiveness of the dietary interventions. The study's findings may not be generalizable to all adolescents with overweight or obesity.
Published in
Publication details and source links for this paper.
Elke D, Mathijs D, Tanja A, et al. The PREVIEW study: Effects of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/obesity. Pediatric Obesity. 2020;16(1):e12702. doi:10.1111/ijpo.12702
No effects of the high protein/low GI diet on insulin resistance (HOMA-IR) were observed.
The retention rate for participants in the study was 39%.
Evidence network
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This study contributes evidence to High-protein, low-GI diet, Moderate-protein, moderate-GI diet and Insulin resistance, Participant retention at 6 months.
This study contributes evidence to
Primary intervention
High-protein, low-GI diet
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
4
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
High-protein, low-GI diet → Insulin resistance
High-protein, low-GI diet → Insulin resistance
High-protein, low-GI diet → Participant retention at 6 months
High-protein, low-GI diet → Participant retention at 6 months
Moderate-protein, moderate-GI diet → Insulin resistance
Moderate-protein, moderate-GI diet → Insulin resistance
Moderate-protein, moderate-GI diet → Participant retention at 6 months
Moderate-protein, moderate-GI diet → Participant retention at 6 months
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on High-protein, low-GI diet and Insulin Resistance, High-protein, low-GI diet and Participant retention at 6 months.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies on High-protein, low-GI diet
Contributes to High-protein, low-GI diet evidence base.
All studies measuring Insulin Resistance
Measures Insulin Resistance as a key outcome.
All studies measuring Participant retention at 6 months
Measures Participant retention at 6 months as a key outcome.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear benefit of High-protein, low-GI diet for Insulin resistance.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Insulin resistance
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of High-protein, low-GI diet for Participant retention at 6 months.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Participant retention at 6 months
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Moderate-protein, moderate-GI diet for Insulin resistance.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Insulin resistance
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Moderate-protein, moderate-GI diet for Participant retention at 6 months.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Participant retention at 6 months
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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