Last updated August 18, 2026
Key finding
Average glucose decreased to 180 mg/dL with HCLS.
HCLS with U10 significantly improved glycemic control in a neonatal diabetes patient.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
HCLS with U10 significantly improved glycemic control in a neonatal diabetes patient.
This study evaluated HCLS with U10 significantly improved glycemic control in a neonatal diabetes patient.
Limitations were not clearly described in the extracted text.
Published in
Publication details and source links for this paper.
Alexandra LG, Christine B, Kimberly M, Andrea H, Anna LC, Puja S. The earliest implementation of a hybrid closed-loop automated insulin delivery system in a neonatal diabetes patient. JCEM Case Reports. 2026;4(3). doi:10.1210/jcemcr/luaf338
Evidence network
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This study contributes evidence to Hybrid closed-loop system and Average glucose levels measured over 24 hours, Glucose variability, Incidence of hypoglycaemia, and 1 more.
This study contributes evidence to
Primary intervention
Hybrid closed-loop system
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
4
Evidence pairs
430
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Related evidence
Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Hybrid closed-loop system → Average glucose levels measured over 24 hours
Hybrid closed-loop system → Average glucose levels measured over 24 hours
Hybrid closed-loop system → Glucose variability
Hybrid closed-loop system → Glucose variability
Hybrid closed-loop system → Incidence of hypoglycaemia
Hybrid closed-loop system → Incidence of hypoglycaemia
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Insulin Delivery Systems and CGM Time in Range, Insulin Delivery Systems and Glucose Variability.
This study contributes to the evidence on the following intervention-outcome relationships.
Devices & Technology
Devices & Technology
Curated evidence collections and hubs this study is part of.
All studies measuring CGM Time in Range
Measures CGM Time in Range as a key outcome.
All studies on Insulin Delivery Systems
Contributes to Insulin Delivery Systems evidence base.
All studies measuring Glucose Variability
Measures Glucose Variability as a key outcome.
Latest published studies
Published within the last 2 years.
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9 results
3 results
9 results
9 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
Insulin Delivery Systems may improve CGM Time in Range.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Time in range
EvidenceScore™ Strong | EvidenceScore™ 85.9 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 17 supporting studies with generally consistent results and a positive effect signal.
Limitations
Insulin Delivery Systems may improve Glucose Variability.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Glucose variability
EvidenceScore™ Strong | EvidenceScore™ 79.0 | weak positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on 5 supporting studies with generally consistent results and a positive effect signal.
Limitations
Insulin Delivery Systems may improve Hypoglycemia.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Incidence of hypoglycaemia
EvidenceScore™ Strong | EvidenceScore™ 83.8 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 7 supporting studies with generally consistent results and a positive effect signal.
Limitations
Hybrid closed-loop system appears to improve Average glucose levels measured over 24 hours.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Average glucose levels measured over 24 hours
EvidenceScore™ Unknown | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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