Last updated July 17, 2026
Key finding
Weight loss after VLCD phase (mean) was 6.7 kg (range: -6.8 to 11.2 kg).
This study explored barriers and facilitators affecting weight loss behavior in obese individuals with early Type 2 diabetes, finding an average weight loss of 6.7 kg after a Very Low Calorie Diet.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study explored barriers and facilitators affecting weight loss behavior in obese individuals with early Type 2 diabetes, finding an average weight loss of 6.7 kg after a Very Low Calorie Diet.
Understanding the barriers and facilitators to weight loss in this population is crucial for developing effective interventions. As obesity and Type 2 diabetes are significant health concerns, addressing these issues can lead to improved health outcomes and quality of life for affected individuals.
No specific satisfaction scores were reported. Limited data on complications in neonates. Effectiveness of the intervention remains unclear.
Published in
Publication details and source links for this paper.
Andrew YWL, Shu YT, Sabrina PSL, Shannon YXG, Wern ET. Exploring Barriers and Facilitators Affecting Behavior Changes for Weight Loss in Obese Individuals with Early Type 2 Diabetes. AACE Endocrinology and Diabetes. 2026;13(3):421-427. doi:10.1016/j.aed.2026.02.017
Average weight loss of 6.7 kg after VLCD phase.
Participants reported challenges in sustaining motivation for the diet.
Improved sense of well-being reported through weight loss.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Very-low-calorie ketogenic diet and Improved Sense of Well-Being through Weight Loss, Participants' satisfaction evaluation of the APP, Proportion of subjects with hs-CRP < 2 mg/L, and 3 more.
This study contributes evidence to
Primary intervention
Very-low-calorie ketogenic diet
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
6
Evidence pairs
8
Related studies
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_intervention
Core evidence
The primary outcomes reported in this study.
Very-low-calorie ketogenic diet → Improved Sense of Well-Being through Weight Loss
Very-low-calorie ketogenic diet → Improved Sense of Well-Being through Weight Loss
Very-low-calorie ketogenic diet → Participants' satisfaction evaluation of the APP
Very-low-calorie ketogenic diet → Participants' satisfaction evaluation of the APP
Very-low-calorie ketogenic diet → Proportion of subjects with hs-CRP < 2 mg/L
Very-low-calorie ketogenic diet → Proportion of subjects with hs-CRP < 2 mg/L
Very-low-calorie ketogenic diet → Psychological barriers to adhering to a calorie-restricted diet
Very-low-calorie ketogenic diet → Psychological barriers to adhering to a calorie-restricted diet
Very-low-calorie ketogenic diet → Rate of neonates with more than one complication
Very-low-calorie ketogenic diet → Rate of neonates with more than one complication
Very-low-calorie ketogenic diet → Weight loss of 10% or more at 52 weeks
Very-low-calorie ketogenic diet → Weight loss of 10% or more at 52 weeks
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Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Ketogenic Diets and Weight loss of 10% or more at 52 weeks, Ketogenic Diets and Improved Sense of Well-Being through Weight Loss.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies on Ketogenic Diets
Contributes to Ketogenic Diets evidence base.
All studies measuring Weight loss of 10% or more at 52 weeks
Measures Weight loss of 10% or more at 52 weeks as a key outcome.
All studies measuring Improved Sense of Well-Being through Weight Loss
Measures Improved Sense of Well-Being through Weight Loss as a key outcome.
All studies measuring Rate of neonates with more than one complication
Measures Rate of neonates with more than one complication as a key outcome.
Latest published studies
Published within the last 2 years.
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2 results
1 results
2 results
2 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Very-low-calorie ketogenic diet appears to improve Weight loss of 10% or more at 52 weeks.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Weight loss of 10% or more at 52 weeks
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Very-low-calorie ketogenic diet appears to improve Improved Sense of Well-Being through Weight Loss.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Improved Sense of Well-Being through Weight Loss
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Very-low-calorie ketogenic diet for Participants' satisfaction evaluation of the APP.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Participants' satisfaction evaluation of the APP
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Very-low-calorie ketogenic diet for Proportion of subjects with hs-CRP < 2 mg/L.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Proportion of subjects with hs-CRP < 2 mg/L
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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