Evidence Intelligence™
- EvidenceScore™
- 87
- Strong
- ImpactScore™
- 67
- Slightly Positive
- ConsistencyScore™
- 56
- generally_consistent
Supporting studies: Based on 9 studies
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Intensive lifestyle intervention improves diabetes remission in India
Last updated August 18, 2026
Key finding
Weight decreased by 8.5% in the remission group compared to 5.2% in the non-remission group.
BL21 probiotic added to metformin in adults with type 2 diabetes.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
BL21 probiotic added to metformin in adults with type 2 diabetes.
Clinical relevance
This study evaluated BL21 probiotic added to metformin in adults with type 2 diabetes.
Keep in mind
Limitations were not clearly described in the extracted text.
Published in
Journal Reference
Publication details and source links for this paper.
Pramod T, Nidhi K, Thejas K, et al. Predictors of type 2 diabetes remission following intensive lifestyle intervention in an Indian population. PLOS One. 2025;20(10):e0333114. doi:10.1371/journal.pone.0333114
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Lifestyle intervention for prediabetes and BMI, Body weight, Fasting insulin levels, and 3 more.
This study contributes evidence to
Primary intervention
Lifestyle intervention for prediabetes
Primary outcomes
- BMI
- Body weight
- Fasting insulin levels
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
6
Evidence pairs
6
Relationships
4
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
4
Related topics
6
Evidence pairs
1386
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 6 evidence relationships
- Includes primary outcome data
- Linked to 4 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Prediabetes
matched_intervention_and_outcome
Related evidence
Evidence topic
Weight Loss
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Body weight
Lifestyle intervention for prediabetes → Body weight
Lifestyle intervention for prediabetes → Body weight
Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 75
- Positive
- ConsistencyScore™
- 83
- consistent
Supporting studies: Based on 12 studies
Add to Evidence TrackerFasting insulin levels
Lifestyle intervention for prediabetes → Fasting insulin levels
Lifestyle intervention for prediabetes → Fasting insulin levels
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 75
- Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 87
- Strong
- ImpactScore™
- 85
- Very Positive
- ConsistencyScore™
- 82
- consistent
Supporting studies: Based on 17 studies
Add to Evidence TrackerHomeostatic Model Assessment of Beta-cell function (HOMA-β)
Lifestyle intervention for prediabetes → Homeostatic Model Assessment of Beta-cell function (HOMA-β)
Lifestyle intervention for prediabetes → Homeostatic Model Assessment of Beta-cell function (HOMA-β)
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
Add to Evidence TrackerInsulin resistance
Lifestyle intervention for prediabetes → Insulin resistance
Lifestyle intervention for prediabetes → Insulin resistance
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 75
- Positive
- ConsistencyScore™
- 75
- consistent
Supporting studies: Based on 4 studies
Add to Evidence TrackerEvidence Library
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Evidence Library
Build your evidence library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Lifestyle intervention for prediabetes and HbA1c, Lifestyle intervention for prediabetes and Body Mass Index.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Lifestyle intervention for prediabetes → HbA1c
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- 87
- Strong
- ImpactScore™
- 85
- Very Positive
- ConsistencyScore™
- 82
- consistent
Supporting studies: Based on 17 studies
View evidenceBehavioral & Lifestyle
Lifestyle intervention for prediabetes → Body Mass Index
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- 87
- Strong
- ImpactScore™
- 67
- Slightly Positive
- ConsistencyScore™
- 56
- generally_consistent
Supporting studies: Based on 9 studies
View evidenceBehavioral & Lifestyle
Lifestyle intervention for prediabetes → Body Weight
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 75
- Positive
- ConsistencyScore™
- 83
- consistent
Supporting studies: Based on 12 studies
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
HbA1c Evidence Hub
All studies measuring HbA1c
17 studies
outcome_hubMeasures HbA1c as a key outcome.
Lifestyle intervention for prediabetes Evidence Hub
All studies on Lifestyle intervention for prediabetes
17 studies
intervention_hubContributes to Lifestyle intervention for prediabetes evidence base.
Body Weight Evidence Hub
All studies measuring Body Weight
12 studies
outcome_hubMeasures Body Weight as a key outcome.
Body Mass Index Evidence Hub
All studies measuring Body Mass Index
9 studies
outcome_hubMeasures Body Mass Index as a key outcome.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Lifestyle intervention for prediabetes and HbA1c
Intervention: Lifestyle intervention for prediabetesOutcome: HbA1c
17 results
All studies on Lifestyle intervention for prediabetes and BMI
Intervention: Lifestyle intervention for prediabetesOutcome: BMI
9 results
All studies on Lifestyle intervention for prediabetes
Intervention: Lifestyle intervention for prediabetes
17 results
All studies measuring HbA1c
Outcome: HbA1c
17 results
All studies measuring BMI
Outcome: BMI
9 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Lifestyle intervention for prediabetes lower HbA1c?
Strong Evidence
Lifestyle intervention for prediabetes appears to lower HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 87.4 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Lifestyle intervention for prediabetes affect BMI?
Strong Evidence
Lifestyle intervention for prediabetes may affect BMI.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
BMI
EvidenceScore™ Strong | EvidenceScore™ 86.7 | weak positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Lifestyle intervention for prediabetes affect body weight?
Strong Evidence
Lifestyle intervention for prediabetes may affect body weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Body weight
EvidenceScore™ Strong | EvidenceScore™ 84.1 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Lifestyle intervention for prediabetes improve insulin resistance?
Strong Evidence
Lifestyle intervention for prediabetes may improve insulin resistance.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Insulin resistance
EvidenceScore™ Strong | EvidenceScore™ 79.0 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Next steps
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Related research
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Intensive lifestyle intervention may improve type 2 diabetes remission ratesHealthy lifestyle reduces diabetes risk in high genetic risk womenCommunity lifestyle programme improves multiple diabetes risk factors in adults with prediabetesEngagement in a prediabetes education programme is linked to lower type 2 diabetes riskHome-based intervention may help prevent diabetes in women with GDM
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