Last updated September 3, 2026
Key finding
25(OH)D had an ILI-related increase of 2.04 ng/mL (95% CI: 0.20, 3.88).
This study investigated the effects of an intensive lifestyle intervention on calcium metabolism hormones in adults with type 2 diabetes, revealing an increase in 25-hydroxyvitamin D and a decrease in parathyroid hormone.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study investigated the effects of an intensive lifestyle intervention on calcium metabolism hormones in adults with type 2 diabetes, revealing an increase in 25-hydroxyvitamin D and a decrease in parathyroid hormone.
These findings are significant because they suggest that lifestyle changes can positively influence vitamin D metabolism and parathyroid hormone levels, potentially improving health outcomes for individuals with type 2 diabetes. This could lead to better management of diabetes-related complications and enhance bone health.
Effectiveness of the intervention remains unclear due to limited data No significant treatment effect observed for vitamin D-binding protein Sample size and demographic details not specified
Published in
Publication details and source links for this paper.
Jiahuan HH, Chigolum PO, Jianqiao M, et al. Intensive Lifestyle Intervention and Hormones Regulating Calcium Metabolism in Adults with Type 2 Diabetes. Journal of the Endocrine Society. 2026;10(5):bvag089. doi:10.1210/jendso/bvag089
25-hydroxyvitamin D increased by 2.04 ng/mL (95% CI: 0.20, 3.88)
Parathyroid hormone decreased by 6.75 pg/mL (95% CI: -11.4, 2.13)
No significant change in vitamin D-binding protein was observed
Evidence network
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This study contributes evidence to Lifestyle intervention for prediabetes and Change in plasma levels of parathyroid hormone (PTH), Serum 25-hydroxyvitamin D, Vitamin D-binding protein.
This study contributes evidence to
Primary intervention
Lifestyle intervention for prediabetes
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
3
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Lifestyle intervention for prediabetes → Change in plasma levels of parathyroid hormone (PTH)
Lifestyle intervention for prediabetes → Change in plasma levels of parathyroid hormone (PTH)
Lifestyle intervention for prediabetes → Serum 25-hydroxyvitamin D
Lifestyle intervention for prediabetes → Serum 25-hydroxyvitamin D
Lifestyle intervention for prediabetes → Vitamin D-binding protein
Lifestyle intervention for prediabetes → Vitamin D-binding protein
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Lifestyle intervention for prediabetes and Change in plasma levels of parathyroid hormone (PTH), Lifestyle intervention for prediabetes and Adipokine and Angiogenic Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies measuring Change in plasma levels of parathyroid hormone (PTH)
Measures Change in plasma levels of parathyroid hormone (PTH) as a key outcome.
All studies on Lifestyle intervention for prediabetes
Contributes to Lifestyle intervention for prediabetes evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Lifestyle intervention for prediabetes appears to improve change in plasma levels of parathyroid hormone (PTH).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Change in plasma levels of parathyroid hormone (PTH)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Lifestyle intervention for prediabetes appears to improve serum 25-hydroxyvitamin d.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Serum 25-hydroxyvitamin D
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Lifestyle intervention for prediabetes for vitamin d-binding protein.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Vitamin D-binding protein
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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