Last updated June 11, 2026
Key finding
HR 0.42 (95% CI 0.29 to 0.60) p<0.001; 45/379 intervention vs 94/370 control
This study combined data from three European trials of lifestyle programmes for people with prediabetes. The lifestyle programme cut diabetes risk by 57% overall, and those who lost 5% or more of their body weight in the first year had a 65% lower risk. Keeping the weight off for longer led to even greater protection.
Quick read
The essential study design details in one scan.
EvidenceScore™
High
Study type
Pooled IPD analysis of three randomised controlled trials
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study combined data from three European trials of lifestyle programmes for people with prediabetes. The lifestyle programme cut diabetes risk by 57% overall, and those who lost 5% or more of their body weight in the first year had a 65% lower risk. Keeping the weight off for longer led to even greater protection.
This pooled analysis reinforces the strong evidence that lifestyle intervention works for diabetes prevention across different European populations. The finding that 5% weight loss is a simple, meaningful target is important for monitoring real-world programmes. The risk prediction analysis highlights the challenge of deciding who to prioritise for limited prevention resources.
Pooled analysis combines trials with some variability in intervention delivery across sites Weight loss analysis is per-protocol, not ITT — people who lost weight may have differed in other ways Limited to three European populations — may not generalise to other regions or ethnic groups Follow-up limited to mean 3.1 years
↓ T2D incidence by 57% in lifestyle intervention vs control (HR 0.42, 95% CI 0.29–0.60, p<0.001)
↓ T2D incidence by 65% in those with ≥5% weight loss at 1 year (HR 0.35, 95% CI 0.22–0.56, p<0.001)
Sustained ≥5% weight loss at 2–3 years associated with further risk reduction
Evidence network
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This study contributes evidence to Lifestyle intervention for prediabetes and Body weight, Type 2 diabetes incidence.
This study contributes evidence to
Primary intervention
Lifestyle intervention for prediabetes
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
2
Evidence pairs
807
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_intervention_and_outcome
Related evidence
Evidence topic
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Core evidence
The primary outcomes reported in this study.
Lifestyle intervention for prediabetes → Body weight
Lifestyle intervention for prediabetes → Body weight
Lifestyle intervention for prediabetes → Type 2 diabetes incidence
Lifestyle intervention for prediabetes → Type 2 diabetes incidence
Evidence Library
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Lifestyle intervention for prediabetes and Diabetes Incidence and Prevention, Lifestyle intervention for prediabetes and Body Weight.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
All studies measuring Diabetes Incidence and Prevention
Measures Diabetes Incidence and Prevention as a key outcome.
All studies on Lifestyle intervention for prediabetes
Contributes to Lifestyle intervention for prediabetes evidence base.
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8 results
12 results
8 results
8 results
12 results
Generated from the study's connected evidence using Evidence Intelligence™.
Lifestyle intervention for prediabetes may reduce type 2 diabetes incidence.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Type 2 diabetes incidence
EvidenceScore™ Strong | EvidenceScore™ 87.9 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Lifestyle intervention for prediabetes may affect body weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Body weight
EvidenceScore™ Strong | EvidenceScore™ 84.1 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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