Last updated September 2, 2026
Key finding
Inulin supplementation significantly decreased fasting plasma glucose (FPG) in comparison to the placebo group (P<0.001).
This study investigated the effects of high performance inulin supplementation on glucose homeostasis in adults with type 2 diabetes. It found significant improvements in fasting plasma glucose and KLF5 mRNA expression compared to placebo.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of high performance inulin supplementation on glucose homeostasis in adults with type 2 diabetes. It found significant improvements in fasting plasma glucose and KLF5 mRNA expression compared to placebo.
These findings are clinically significant as they suggest that high performance inulin supplementation could be a beneficial dietary intervention for managing blood sugar levels in adults with type 2 diabetes. Improved glucose homeostasis can lead to better overall health outcomes and potentially reduce the risk of diabetes-related complications.
Limited sample size may affect generalizability. Short duration of the study may not capture long-term effects. Lack of diversity in the participant population.
Published in
Publication details and source links for this paper.
Abed G, Neda R, Shahriar A, et al. The effect of high performance inulin supplementation on glucose homeostasis via KLF5 mRNA expression in adults with type 2 diabetes. Advanced Pharmaceutical Bulletin. 2018;8(1):39-47. doi:10.15171/apb.2018.005
Inulin supplementation decreased fasting plasma glucose by 7.46 mg/dl (P<0.001).
Inulin reduced KLF5 mRNA expression by 0.61 fold (P=0.001).
Inulin increased plasmatic level of miR-375 by 3.75 fold (P=0.004).
Evidence network
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This study contributes evidence to High performance inulin supplementation, Starch placebo and Fasting Plasma Glucose (FPG), KLF5 mRNA expression decrease, Plasmatic level of miR-375.
This study contributes evidence to
Primary intervention
High performance inulin supplementation
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
6
Evidence pairs
886
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Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
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Core evidence
The primary outcomes reported in this study.
High performance inulin supplementation → Fasting Plasma Glucose (FPG)
High performance inulin supplementation → Fasting Plasma Glucose (FPG)
High performance inulin supplementation → KLF5 mRNA expression decrease
High performance inulin supplementation → KLF5 mRNA expression decrease
High performance inulin supplementation → Plasmatic level of miR-375
High performance inulin supplementation → Plasmatic level of miR-375
Starch placebo → Fasting Plasma Glucose (FPG)
Starch placebo → Fasting Plasma Glucose (FPG)
Starch placebo → KLF5 mRNA expression decrease
Starch placebo → KLF5 mRNA expression decrease
Starch placebo → Plasmatic level of miR-375
Starch placebo → Plasmatic level of miR-375
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on High performance inulin supplementation and Fasting Glucose, High performance inulin supplementation and KLF5 mRNA expression decrease.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies on High performance inulin supplementation
Contributes to High performance inulin supplementation evidence base.
All studies measuring KLF5 mRNA expression decrease
Measures KLF5 mRNA expression decrease as a key outcome.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
High performance inulin supplementation appears to improve fasting plasma glucose (FPG).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
High performance inulin supplementation appears to improve klf5 mrna expression decrease.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
KLF5 mRNA expression decrease
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
High performance inulin supplementation appears to improve plasmatic level of mir-375.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Plasmatic level of miR-375
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Starch placebo for fasting plasma glucose (FPG).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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