Evidence Intelligence™
- EvidenceScore™
- 87
- Strong
- ImpactScore™
- 63
- Slightly Positive
- ConsistencyScore™
- 63
- generally_consistent
Supporting studies: Based on 8 studies
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Lifestyle intervention shows little effect on weight loss in women with gestational diabetes
Last updated September 9, 2026
Key finding
A mean weight change of -2.0 (SD 7.1) kg was observed in the intervention group compared with -0.6 (SD 8.0) kg in the control group, difference -1.4 (95% CI -4.4, 1.5) kg from 6 weeks to 12 months postnatal, but this was not statistically significant (P = .34).
The PAIGE2 Study evaluated a multicomponent lifestyle intervention for women with gestational diabetes, finding a mean weight change of -2.0 kg in the intervention group compared to -0.6 kg in the control group.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
The PAIGE2 Study evaluated a multicomponent lifestyle intervention for women with gestational diabetes, finding a mean weight change of -2.0 kg in the intervention group compared to -0.6 kg in the control group.
Clinical relevance
Understanding the effectiveness of lifestyle interventions for women with gestational diabetes is crucial, as it may help in managing weight and preventing complications. While the intervention showed some promise in weight reduction, the lack of significant changes in other health markers suggests that further research is needed to determine its overall impact.
Keep in mind
The effectiveness of the intervention remains unclear due to non-significant results for secondary outcomes. The sample size and population characteristics may limit generalizability. No significant differences were found in key health markers beyond weight change.
Published in
Journal Reference
Publication details and source links for this paper.
Bridie JK, Bronagh K, Georgina C, et al. The PAIGE2 Study: A Multicomponent Lifestyle Intervention for Women with Gestational Diabetes. Journal of the Endocrine Society. 2024;8(10):bvae151. doi:10.1210/jendso/bvae151
Main Effects
The intervention group experienced a mean weight change of -2.0 kg compared to -0.6 kg in the control group (difference -1.4 kg, p=0.34).
No significant difference in BMI change was observed, with a reduction of -0.6 kg/m².
Waist circumference change showed no significant difference, with a reduction of -1.0 cm.
Fasting plasma glucose change was not significant, with a change of 0.07 mmol/L.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Lifestyle intervention for prediabetes and BMI, Fasting Plasma Glucose (FPG), Waist circumference, and 1 more.
This study contributes evidence to
Primary intervention
Lifestyle intervention for prediabetes
Primary outcomes
- BMI
- Fasting Plasma Glucose (FPG)
- Waist circumference
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
4
Evidence pairs
4
Relationships
4
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
4
Related topics
4
Evidence pairs
1251
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 4 evidence relationships
- Includes primary outcome data
- Linked to 4 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Weight Loss
matched_outcome
Related evidence
Evidence topic
Body Composition
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Fasting Plasma Glucose (FPG)
Lifestyle intervention for prediabetes → Fasting Plasma Glucose (FPG)
Lifestyle intervention for prediabetes → Fasting Plasma Glucose (FPG)
Evidence Intelligence™
- EvidenceScore™
- 87
- Strong
- ImpactScore™
- 69
- Positive
- ConsistencyScore™
- 35
- mixed
Supporting studies: Based on 9 studies
Add to Evidence TrackerWaist circumference
Lifestyle intervention for prediabetes → Waist circumference
Lifestyle intervention for prediabetes → Waist circumference
Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 63
- Slightly Positive
- ConsistencyScore™
- 35
- mixed
Supporting studies: Based on 8 studies
Add to Evidence TrackerWeight change
Lifestyle intervention for prediabetes → Weight change
Lifestyle intervention for prediabetes → Weight change
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 63
- Slightly Positive
- ConsistencyScore™
- 75
- consistent
Supporting studies: Based on 4 studies
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- Mean weight loss in the intervention group was -2.0 kg, compared to -0.6 kg in the control group.
- BMI change was -0.6 kg/m², indicating no significant difference.
- Waist circumference change was -1.0 cm, also showing no significant difference.
Who this applies to
- Women diagnosed with gestational diabetes.
- Participants receiving routine maternity care.
Keep in Mind
- The study's findings may not be applicable to all populations due to specific inclusion criteria.
- The lack of significant changes in secondary outcomes suggests caution in interpreting the overall effectiveness.
- Further research is needed to explore the long-term benefits of lifestyle interventions in this population.
Between the Lines
- The effectiveness of the intervention remains unclear due to non-significant results for secondary outcomes.
- The sample size and population characteristics may limit generalizability.
- No significant differences were found in key health markers beyond weight change.
Evidence Library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Lifestyle intervention for prediabetes and Fasting Glucose, Lifestyle intervention for prediabetes and Body Mass Index.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Lifestyle intervention for prediabetes → Fasting Glucose
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- 87
- Strong
- ImpactScore™
- 69
- Positive
- ConsistencyScore™
- 35
- mixed
Supporting studies: Based on 9 studies
View evidenceBehavioral & Lifestyle
Lifestyle intervention for prediabetes → Body Mass Index
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- 87
- Strong
- ImpactScore™
- 63
- Slightly Positive
- ConsistencyScore™
- 63
- generally_consistent
Supporting studies: Based on 8 studies
View evidenceBehavioral & Lifestyle
Lifestyle intervention for prediabetes → Body Weight
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 63
- Slightly Positive
- ConsistencyScore™
- 75
- consistent
Supporting studies: Based on 4 studies
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Fasting Glucose Evidence Hub
All studies measuring Fasting Glucose
9 studies
outcome_hubMeasures Fasting Glucose as a key outcome.
Lifestyle intervention for prediabetes Evidence Hub
All studies on Lifestyle intervention for prediabetes
9 studies
intervention_hubContributes to Lifestyle intervention for prediabetes evidence base.
Body Mass Index Evidence Hub
All studies measuring Body Mass Index
8 studies
outcome_hubMeasures Body Mass Index as a key outcome.
Body Weight Evidence Hub
All studies measuring Body Weight
4 studies
outcome_hubMeasures Body Weight as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Lifestyle intervention for prediabetes and Fasting Plasma Glucose (FPG)
Intervention: Lifestyle intervention for prediabetesOutcome: Fasting Plasma Glucose (FPG)
9 results
All studies on Lifestyle intervention for prediabetes and BMI
Intervention: Lifestyle intervention for prediabetesOutcome: BMI
8 results
All studies on Lifestyle intervention for prediabetes
Intervention: Lifestyle intervention for prediabetes
9 results
All studies measuring Fasting Plasma Glucose (FPG)
Outcome: Fasting Plasma Glucose (FPG)
9 results
All studies measuring BMI
Outcome: BMI
8 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Lifestyle intervention for prediabetes improve fasting plasma glucose (FPG)?
Strong Evidence
Lifestyle intervention for prediabetes may improve fasting plasma glucose (FPG).
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The available evidence reports mixed findings.
Ranked evidence signals
- 1
Fasting Plasma Glucose (FPG)
EvidenceScore™ Strong | EvidenceScore™ 87.1 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
- Only one supporting study is available.
Does Lifestyle intervention for prediabetes affect BMI?
Strong Evidence
Lifestyle intervention for prediabetes may affect BMI.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
BMI
EvidenceScore™ Strong | EvidenceScore™ 87.0 | weak positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Lifestyle intervention for prediabetes affect waist circumference?
Strong Evidence
Lifestyle intervention for prediabetes may affect waist circumference.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The available evidence reports mixed findings.
Ranked evidence signals
- 1
Waist circumference
EvidenceScore™ Strong | EvidenceScore™ 82.6 | weak positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
- Only one supporting study is available.
Does Lifestyle intervention for prediabetes improve weight change?
Strong Evidence
Lifestyle intervention for prediabetes may improve weight change.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Weight change
EvidenceScore™ Strong | EvidenceScore™ 79.0 | weak positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
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