Last updated August 25, 2026
Key finding
BMI decreased by 1.75 kg/m² in the Established group.
This study investigated the impact of lifestyle interventions on plasma BCAA concentrations and BMI in participants, finding varying effects across intervention types.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the impact of lifestyle interventions on plasma BCAA concentrations and BMI in participants, finding varying effects across intervention types.
Understanding how lifestyle interventions affect metabolic markers like BCAA concentrations can help tailor weight loss strategies. Clinicians can use these insights to better support patients in achieving weight loss and improving metabolic health.
Effectiveness of interventions on BCAA concentrations was unclear. Sample size and population characteristics may limit generalizability. Nonsignificant results may indicate the need for larger studies.
Published in
Publication details and source links for this paper.
Yu JL, Rob MVD. Weight loss resulting from lifestyle interventions is associated with reductions in plasma BCAA concentrations. The American Journal of Clinical Nutrition. 2025;122(6):1829-1835. doi:10.1016/j.ajcnut.2025.10.008
Established intervention led to a decrease in plasma BCAA by -7.19 μmol/L (p=0.05).
Established plus DASH intervention resulted in a decrease in plasma BCAA by -8.7 μmol/L (p=0.05).
BMI decreased by 1.75 kg/m² in the Established group and 1.96 kg/m² in the Established plus DASH group.
Evidence network
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This study contributes evidence to Established lifestyle counseling on diet, exercise, and weight loss, Established lifestyle counseling plus DASH diet guidance, Lifestyle advice on weight loss, alcohol, sodium, and physical activity and BMI, Decreases in branched-chain amino acids.
This study contributes evidence to
Primary intervention
Established lifestyle counseling on diet, exercise, and weight loss
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
6
Evidence pairs
240
Related studies
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Established lifestyle counseling on diet, exercise, and weight loss → BMI
Established lifestyle counseling on diet, exercise, and weight loss → BMI
Established lifestyle counseling on diet, exercise, and weight loss → Decreases in branched-chain amino acids
Established lifestyle counseling on diet, exercise, and weight loss → Decreases in branched-chain amino acids
Established lifestyle counseling plus DASH diet guidance → BMI
Established lifestyle counseling plus DASH diet guidance → BMI
Established lifestyle counseling plus DASH diet guidance → Decreases in branched-chain amino acids
Established lifestyle counseling plus DASH diet guidance → Decreases in branched-chain amino acids
Lifestyle advice on weight loss, alcohol, sodium, and physical activity → BMI
Lifestyle advice on weight loss, alcohol, sodium, and physical activity → BMI
Lifestyle advice on weight loss, alcohol, sodium, and physical activity → Decreases in branched-chain amino acids
Lifestyle advice on weight loss, alcohol, sodium, and physical activity → Decreases in branched-chain amino acids
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Lifestyle advice on weight loss, alcohol, sodium, and physical activity and Body Mass Index, Lifestyle advice on weight loss, alcohol, sodium, and physical activity and Decreases in branched-chain amino acids.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring Body Mass Index
Measures Body Mass Index as a key outcome.
All studies measuring Decreases in branched-chain amino acids
Measures Decreases in branched-chain amino acids as a key outcome.
All studies on Lifestyle advice on weight loss, alcohol, sodium, and physical activity
Contributes to Lifestyle advice on weight loss, alcohol, sodium, and physical activity evidence base.
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Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Established lifestyle counseling on diet, exercise, and weight loss appears to improve BMI.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
BMI
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Established lifestyle counseling plus DASH diet guidance appears to improve BMI.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
BMI
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Lifestyle advice on weight loss, alcohol, sodium, and physical activity appears to improve BMI.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
BMI
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Established lifestyle counseling on diet, exercise, and weight loss for Decreases in branched-chain amino acids.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Decreases in branched-chain amino acids
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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