Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 92
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 6 studies
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Baseline Factors Predict Exercise Response in Prediabetes
Last updated September 12, 2026
Key finding
Patients who reversed to normal glucose tolerance were 18 (15.90%).
This study analyzed predictors of exercise response in elderly patients with prediabetes, revealing significant relationships between exercise response and several metabolic factors.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study analyzed predictors of exercise response in elderly patients with prediabetes, revealing significant relationships between exercise response and several metabolic factors.
Clinical relevance
Understanding the predictors of exercise response in elderly patients with prediabetes is crucial for developing targeted interventions. This can help healthcare providers tailor exercise programs to improve metabolic health and potentially reverse prediabetes, reducing the risk of diabetes and its complications.
Keep in mind
Limited sample size may affect generalizability. Retrospective design may introduce bias. Lack of long-term follow-up data.
Published in
Journal Reference
Publication details and source links for this paper.
Yali H, Yanhong F, Junli S, Hong T, Linhui C, Qingqing L. Predictors of Exercise Response in Elderly Patients with Prediabetes: A Retrospective Analysis. Journal of Diabetes Investigation. 2022;13(7):1253-1261. doi:10.1111/jdi.13777
Main Effects
18 participants (15.90%) reversed to normal glucose tolerance.
70 participants (62.00%) remained in prediabetes.
25 participants (22.10%) developed diabetes.
Baseline β-cell function (β = -0.143, P = 0.039) was related to exercise response.
Hemoglobin A1C levels (β = 3.301, P = 0.007) were related to exercise response.
BMI (β = 0.402, P = 0.012) was related to exercise response.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Aerobic exercise, Resistance training and BMI, Homeostatic Model Assessment of Beta-cell function (HOMA-β), Reduction in Hemoglobin A1C levels, and 3 more.
This study contributes evidence to
Primary intervention
Aerobic exercise
Primary outcomes
- BMI
- Homeostatic Model Assessment of Beta-cell function (HOMA-β)
- Reduction in Hemoglobin A1C levels
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
9
Evidence pairs
9
Relationships
7
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
7
Related topics
9
Evidence pairs
1882
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 9 evidence relationships
- Includes primary outcome data
- Linked to 7 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Aerobic Exercise and HbA1c
Related evidence
Evidence relationship
Aerobic Exercise and Body Mass Index
Save evidence
Evidence relationship
Aerobic Exercise and Beta-cell Function
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Homeostatic Model Assessment of Beta-cell function (HOMA-β)
Aerobic exercise → Homeostatic Model Assessment of Beta-cell function (HOMA-β)
Aerobic exercise → Homeostatic Model Assessment of Beta-cell function (HOMA-β)
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 25
- Negative
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerReduction in Hemoglobin A1C levels
Aerobic exercise → Reduction in Hemoglobin A1C levels
Aerobic exercise → Reduction in Hemoglobin A1C levels
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerReversal to normal glucose tolerance
Aerobic exercise → Reversal to normal glucose tolerance
Aerobic exercise → Reversal to normal glucose tolerance
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerType 2 diabetes incidence
Aerobic exercise → Type 2 diabetes incidence
Aerobic exercise → Type 2 diabetes incidence
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 3 studies
Add to Evidence TrackerHomeostatic Model Assessment of Beta-cell function (HOMA-β)
Resistance training → Homeostatic Model Assessment of Beta-cell function (HOMA-β)
Resistance training → Homeostatic Model Assessment of Beta-cell function (HOMA-β)
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 25
- Negative
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerReduction in Hemoglobin A1C levels
Resistance training → Reduction in Hemoglobin A1C levels
Resistance training → Reduction in Hemoglobin A1C levels
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- 15.90% of participants reversed to normal glucose tolerance.
- 62.00% remained in prediabetes, indicating a need for effective interventions.
- Baseline β-cell function and Hemoglobin A1C levels significantly predicted exercise response.
Who this applies to
- Elderly patients aged 65 and older.
- Individuals diagnosed with prediabetes.
Keep in Mind
- Findings may not apply to younger populations.
- Results are based on a specific cohort and may not reflect broader demographics.
- Further research is needed to confirm long-term effects of exercise interventions.
Between the Lines
- Limited sample size may affect generalizability.
- Retrospective design may introduce bias.
- Lack of long-term follow-up data.
Evidence Library
Build your evidence library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Aerobic Exercise and Body Mass Index, Resistance training and Body Mass Index.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Physical Activity
Aerobic Exercise → Body Mass Index
Physical Activity
Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 92
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 6 studies
View evidencePhysical Activity
Resistance training → Body Mass Index
Physical Activity
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 3 studies
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Aerobic Exercise Evidence Hub
All studies on Aerobic Exercise
6 studies
intervention_hubContributes to Aerobic Exercise evidence base.
Body Mass Index Evidence Hub
All studies measuring Body Mass Index
6 studies
outcome_hubMeasures Body Mass Index as a key outcome.
Resistance training Evidence Hub
All studies on Resistance training
3 studies
intervention_hubContributes to Resistance training evidence base.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Aerobic exercise and BMI
Intervention: Aerobic exerciseOutcome: BMI
6 results
All studies on Resistance training and BMI
Intervention: Resistance trainingOutcome: BMI
3 results
All studies on Aerobic exercise
Intervention: Aerobic exercise
6 results
All studies on Resistance training
Intervention: Resistance training
3 results
All studies measuring BMI
Outcome: BMI
6 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Aerobic Exercise lower HbA1c?
Strong Evidence
Aerobic Exercise appears to lower HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Reduction in Hemoglobin A1C levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 13 supporting studies with consistent results and a positive effect signal.
Does Aerobic Exercise affect body mass index?
Strong Evidence
Aerobic Exercise appears to affect body mass index.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
BMI
EvidenceScore™ Strong | EvidenceScore™ 83.4 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 7 supporting studies with consistent results and a positive effect signal.
Does Aerobic Exercise improve beta-cell function?
Emerging Evidence
Aerobic Exercise may worsen beta-cell function or be associated with harm.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Homeostatic Model Assessment of Beta-cell function (HOMA-β)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | moderate negative | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Aerobic Exercise reduce diabetes incidence and prevention?
Emerging Evidence
Current evidence does not show a clear reduction in diabetes incidence and prevention with Aerobic Exercise.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Type 2 diabetes incidence
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Next steps
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