NoneDecrease
Body weight
Liraglutide → Body weight
Liraglutide → Body weight
Evidence profile
NoneDecreaseWeight & Anthropometrics
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Research Summary
Analyzed using Evidence Intelligence™
Liraglutide improves glycaemic control in adults with T2D
Key finding
Overall change in HbA1c was -1.02% for liraglutide compared to -0.28% for placebo.
The study evaluated the addition of liraglutide to SGLT2 inhibitors and metformin in adults with type 2 diabetes, showing significant improvements in glycaemic control.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Some Concerns bias
Last updated July 5, 2026Quick read
Study at a glance
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Liraglutide
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Primary outcome
Haemoglobin A1c (HbA1c)
Comparator
Placebo
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
The study evaluated the addition of liraglutide to SGLT2 inhibitors and metformin in adults with type 2 diabetes, showing significant improvements in glycaemic control.
Clinical relevance
Improving glycaemic control is crucial for managing type 2 diabetes and reducing the risk of complications. The findings suggest that liraglutide can enhance treatment efficacy when combined with standard medications, potentially leading to better health outcomes for patients.
Keep in mind
Non-randomized design may introduce bias. Sample size and diversity not specified. Some outcomes showed no significant differences.
Published in
Journal Reference
Publication details and source links for this paper.
Lawrence B, Udi F, Margit SK, Ofri M, Chethana R, Rosangela R. Liraglutide Added to SGLT2 Inhibitors and Metformin Improves Glycaemic Control in Adults with Type 2 Diabetes. Diabetes, Obesity & Metabolism. 2021;23(10):2234-2241. doi:10.1111/dom.14464
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Main Effects
Liraglutide reduced HbA1c by -1.02% compared to placebo (p = 0.001).
Body weight decreased by -2.92 kg with liraglutide versus -2.06 kg for placebo (p = 0.06).
Waist circumference decreased by -4.26 cm for liraglutide compared to -2.24 cm for placebo (p = 0.05).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Liraglutide and Body weight, Emergency cesarean section rate, HbA1c, and 3 more.
This study contributes evidence to
Primary intervention
Liraglutide
Primary outcomes
- Body weight
- Emergency cesarean section rate
- HbA1c
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
6
Evidence pairs
6
Relationships
4
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
4
Related topics
6
Evidence pairs
301
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 6 evidence relationships
- Includes primary outcome data
- Linked to 4 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
Study findings
The primary outcomes reported in this study.
NoneNo Change
Emergency cesarean section rate
Liraglutide → Emergency cesarean section rate
Liraglutide → Emergency cesarean section rate
Evidence profile
NoneNo ChangeClinical Outcomes
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StrongDecrease
HbA1c
Liraglutide → HbA1c
Liraglutide → HbA1c
Evidence profile
StrongDecreaseGlycemic Control
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NoneNo Change
Type 2 diabetes incidence
Liraglutide → Type 2 diabetes incidence
Liraglutide → Type 2 diabetes incidence
Evidence profile
NoneNo ChangeClinical Outcomes
Unlock full evidence details
NoneNo Change
Urinary tract infection rate
Liraglutide → Urinary tract infection rate
Liraglutide → Urinary tract infection rate
Evidence profile
NoneNo ChangeSafety
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NoneDecrease
Waist circumference
Liraglutide → Waist circumference
Liraglutide → Waist circumference
Evidence profile
NoneDecreaseWeight & Anthropometrics
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Unlock full evidence analysis
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Evidence Suggest
- Liraglutide significantly lowered HbA1c by 1.02%.
- Body weight reduction was greater with liraglutide (-2.92 kg).
- Waist circumference decreased more with liraglutide (-4.26 cm).
Who this applies to
- Adults diagnosed with type 2 diabetes.
- Individuals currently on SGLT2 inhibitors and metformin.
Keep in Mind
- Results may not generalize to all populations.
- Further studies needed to confirm findings.
- Effectiveness of liraglutide may vary among individuals.
Between the Lines
- Non-randomized design may introduce bias.
- Sample size and diversity not specified.
- Some outcomes showed no significant differences.
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on GLP-1 Receptor Agonists and HbA1c, GLP-1 Receptor Agonists and Body Weight.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
Body Weight Evidence Hub
All studies measuring Body Weight
3 studies
outcome_hubMeasures Body Weight as a key outcome.
GLP-1 Receptor Agonists Evidence Hub
All studies on GLP-1 Receptor Agonists
2 studies
intervention_hubContributes to GLP-1 Receptor Agonists evidence base.
HbA1c Evidence Hub
All studies measuring HbA1c
2 studies
outcome_hubMeasures HbA1c as a key outcome.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Liraglutide and HbA1c
Intervention: LiraglutideOutcome: HbA1c
2 results
All studies on Liraglutide and Body weight
Intervention: LiraglutideOutcome: Body weight
3 results
All studies on Liraglutide
Intervention: Liraglutide
2 results
All studies measuring HbA1c
Outcome: HbA1c
2 results
All studies measuring Body weight
Outcome: Body weight
3 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does GLP-1 Receptor Agonists improve HbA1c?
Moderate Evidence
GLP-1 Receptor Agonists appears to improve HbA1c.
ConsensusScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Moderate | EvidenceScore™ 60.6 | strong positive | ConsensusScore™ Consistent | 1 study
Why this answer: This answer is based on 24 supporting studies with consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does GLP-1 Receptor Agonists affect body weight?
Emerging Evidence
GLP-1 Receptor Agonists may improve Body Weight.
ConsensusScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Body weight
EvidenceScore™ Emerging | EvidenceScore™ 52.2 | moderate positive | ConsensusScore™ Consistent | 1 study
Why this answer: This answer is based on 23 supporting studies with consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does GLP-1 Receptor Agonists improve body composition?
Emerging Evidence
GLP-1 Receptor Agonists may improve Body Composition.
ConsensusScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Waist circumference
EvidenceScore™ Limited | EvidenceScore™ 35.5 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on 5 supporting studies with consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does GLP-1 Receptor Agonists improve diabetes incidence and prevention?
Limited Evidence
Current evidence does not show a clear benefit of GLP-1 Receptor Agonists for Diabetes Incidence and Prevention.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Type 2 diabetes incidence
EvidenceScore™ Limited | EvidenceScore™ 35.5 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a small number of supporting studies and should be interpreted cautiously.
Limitations
- Only a small number of supporting studies are available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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