Last updated July 3, 2026
Key finding
Cholesterol levels decreased significantly in the control group (p = 0.003).
This study investigated the effects of magnesium and potassium supplementation on cholesterol levels and quality of life in patients with type 2 diabetes mellitus, finding significant improvements in both areas.
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EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study investigated the effects of magnesium and potassium supplementation on cholesterol levels and quality of life in patients with type 2 diabetes mellitus, finding significant improvements in both areas.
These findings highlight the potential role of magnesium and potassium supplementation in managing cholesterol levels and enhancing the quality of life for individuals with type 2 diabetes. As diabetes management is critical for preventing complications, incorporating these supplements could offer a simple and effective strategy for improving patient outcomes.
The study did not assess long-term effects of supplementation. Sample size and demographics may limit generalizability. Potential confounding factors were not fully controlled.
Published in
Publication details and source links for this paper.
Sidra K, Riffat M, Syeda Shazia B, et al. The effect of magnesium and potassium supplementation on cholesterol levels and quality of life in patients with type 2 diabetes mellitus. Endocrinology, Diabetes & Metabolism. 2024;7(6):e511. doi:10.1002/edm2.511
Cholesterol levels decreased by 34.4 mg/dL in the control group (p = 0.003).
Cholesterol levels decreased by 39 mg/dL in the magnesium group (p = 0.00006).
Cholesterol levels decreased by 61.5 mg/dL in the potassium group (p < 0.000001).
Quality of life improved significantly in the magnesium group (p < 0.000001).
Evidence network
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This study contributes evidence to Combined magnesium and potassium supplements, Magnesium supplement and LDL cholesterol, Quality of life.
This study contributes evidence to
Primary intervention
Combined magnesium and potassium supplements
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
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Evidence network role
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Primary evidence
Evidence relationship
Related evidence
Evidence relationship
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Intervention
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Core evidence
The primary outcomes reported in this study.
Combined magnesium and potassium supplements → LDL cholesterol
Combined magnesium and potassium supplements → LDL cholesterol
Combined magnesium and potassium supplements → Quality of life
Combined magnesium and potassium supplements → Quality of life
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Magnesium Supplements and Adipokine and Angiogenic Markers, Magnesium Supplements and Quality of Life Outcomes.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies on Magnesium Supplements
Contributes to Magnesium Supplements evidence base.
All studies measuring Quality of Life Outcomes
Measures Quality of Life Outcomes as a key outcome.
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Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Magnesium Supplements may improve Adipokine and Angiogenic Markers.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
LDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 3 supporting studies with generally consistent results and a positive effect signal.
Limitations
Magnesium Supplements appears to improve Quality of Life Outcomes.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Quality of life
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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