Last updated September 4, 2026
Key finding
A significant association was revealed by analysis among pre- and post-trial serum urea level and magnesium supplementation, p = 0.000.
This study investigated the effects of magnesium and potassium supplementation on markers of diabetic nephropathy in patients with insomnia, finding significant improvements in certain serum markers.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study investigated the effects of magnesium and potassium supplementation on markers of diabetic nephropathy in patients with insomnia, finding significant improvements in certain serum markers.
The findings suggest that magnesium and potassium supplementation could be beneficial for patients with diabetic nephropathy, particularly those experiencing insomnia. Improved kidney function markers may lead to better management of diabetes-related complications, highlighting the importance of nutritional interventions in this population.
Limited sample size may affect generalizability. Short duration of study may not capture long-term effects. Lack of diversity in population limits applicability.
Published in
Publication details and source links for this paper.
Sidra K, Shahid B, Riffat M, et al. Effects of Magnesium and Potassium Supplementation on Diabetic Nephropathy Markers in Patients with Insomnia. Health Science Reports. 2026;9(1):e71738. doi:10.1002/hsr2.71738
Magnesium supplementation significantly decreased serum urea by -1.31 mg/dL (p = 0.000).
Magnesium supplementation significantly decreased serum creatinine by -0.13 mg/dL (p = 0.000).
Combination of magnesium and potassium significantly decreased serum AST by -2.5 U/L (p = 0.004).
Evidence network
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This study contributes evidence to Combined magnesium and potassium supplements, Magnesium gluconate, Potassium (K) and AST, Rheumatoid Arthritis (RA) factor, Alanine Aminotransferase (ALT), and 3 more.
This study contributes evidence to
Primary intervention
Combined magnesium and potassium supplements
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
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6
Evidence pairs
506
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Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Combined magnesium and potassium supplements → AST
Combined magnesium and potassium supplements → AST
Combined magnesium and potassium supplements → Rheumatoid Arthritis (RA) factor
Combined magnesium and potassium supplements → Rheumatoid Arthritis (RA) factor
Magnesium gluconate → Alanine Aminotransferase (ALT)
Magnesium gluconate → Alanine Aminotransferase (ALT)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Magnesium Supplements and AST, Magnesium Supplements and Rheumatoid Arthritis (RA) factor.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Curated evidence collections and hubs this study is part of.
All studies measuring AST
Measures AST as a key outcome.
All studies on Magnesium Supplements
Contributes to Magnesium Supplements evidence base.
All studies measuring Rheumatoid Arthritis (RA) factor
Measures Rheumatoid Arthritis (RA) factor as a key outcome.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Combined magnesium and potassium supplements appears to improve ast.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
AST
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Combined magnesium and potassium supplements appears to improve rheumatoid arthritis (RA) factor.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Rheumatoid Arthritis (RA) factor
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Magnesium gluconate appears to improve alanine aminotransferase (ALT).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Alanine Aminotransferase (ALT)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Magnesium gluconate appears to improve serum creatinine.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Serum creatinine
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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