Last updated September 9, 2026
Key finding
The adherence rate in the intervention group increased by 50%.
This study evaluated the impact of medication therapy management on medication adherence in patients with diabetes and hypertension, finding a significant increase in adherence rates.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the impact of medication therapy management on medication adherence in patients with diabetes and hypertension, finding a significant increase in adherence rates.
Improving medication adherence is crucial for managing chronic conditions like diabetes and hypertension. Enhanced adherence can lead to better health outcomes, reduced complications, and lower healthcare costs. This study demonstrates that structured medication therapy management can effectively support patients in adhering to their treatment plans.
Limited generalizability due to specific population characteristics. Potential biases in self-reported adherence measures. Unmeasured confounders may affect outcomes.
Published in
Publication details and source links for this paper.
Tadesse S, Firomsa B, Wayessa O, Birbirsa S. The impact of medication therapy management on medication adherence among patients comorbid with diabetes mellitus and hypertension: A cluster randomized controlled trial. Cardiovascular diabetology. Endocrinology reports. 2025;11:41. doi:10.1186/s40842-025-00254-4
Medication adherence rate increased by 50% in the intervention group (p < 0.001).
Baseline adherence was 23.7% in the intervention group and 20.3% in the control group (p = 0.420).
Final adherence improved from 23.7% to 73.7% in the intervention group.
Evidence network
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This study contributes evidence to EWS plus Medication Therapy Management (EWS + MTM) and Baseline medication adherence, Proportion of participants with good medication adherence.
This study contributes evidence to
Primary intervention
EWS plus Medication Therapy Management (EWS + MTM)
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
2
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
EWS plus Medication Therapy Management (EWS + MTM) → Baseline medication adherence
EWS plus Medication Therapy Management (EWS + MTM) → Baseline medication adherence
EWS plus Medication Therapy Management (EWS + MTM) → Proportion of participants with good medication adherence
EWS plus Medication Therapy Management (EWS + MTM) → Proportion of participants with good medication adherence
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on EWS plus Medication Therapy Management (EWS + MTM) and Baseline medication adherence, EWS plus Medication Therapy Management (EWS + MTM) and Proportion of participants with good medication adherence.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring Baseline medication adherence
Measures Baseline medication adherence as a key outcome.
All studies on EWS plus Medication Therapy Management (EWS + MTM)
Contributes to EWS plus Medication Therapy Management (EWS + MTM) evidence base.
All studies measuring Proportion of participants with good medication adherence
Measures Proportion of participants with good medication adherence as a key outcome.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
EWS plus Medication Therapy Management (EWS + MTM) appears to improve proportion of participants with good medication adherence.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Proportion of participants with good medication adherence
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of EWS plus Medication Therapy Management (EWS + MTM) for baseline medication adherence.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Baseline medication adherence
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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