Last updated August 18, 2026
Key finding
Approximately 15% reduction in body weight over 3 months.
A whole-food Mediterranean ketogenic diet compared to a very-low-calorie ketogenic diet in adults with obesity.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
Non-randomized CT
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
A whole-food Mediterranean ketogenic diet compared to a very-low-calorie ketogenic diet in adults with obesity.
This study evaluated A whole-food Mediterranean ketogenic diet compared to a very-low-calorie ketogenic diet in adults with obesity.
Limitations were not clearly described in the extracted text.
Published in
Publication details and source links for this paper.
Davide M, Maria LS, Elena C, et al. A Whole-Food Mediterranean Ketogenic Diet Achieves Comparable Weight Loss to a Very-Low-Calorie Ketogenic Diet. Metabolites. 2026;16(4). doi:10.3390/metabo16040248
Evidence network
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This study contributes evidence to Mediterranean ketogenic diet, Very-low-calorie ketogenic diet and Insulin resistance, Percentage weight loss after 12 weeks, Serum creatinine, and 2 more.
This study contributes evidence to
Primary intervention
Mediterranean ketogenic diet
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
10
Evidence pairs
648
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Related evidence
Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Mediterranean ketogenic diet → Insulin resistance
Mediterranean ketogenic diet → Insulin resistance
Mediterranean ketogenic diet → Percentage weight loss after 12 weeks
Mediterranean ketogenic diet → Percentage weight loss after 12 weeks
Mediterranean ketogenic diet → Serum creatinine
Mediterranean ketogenic diet → Serum creatinine
Mediterranean ketogenic diet → Waist circumference
Mediterranean ketogenic diet → Waist circumference
Mediterranean ketogenic diet → Waist-to-hip ratio
Mediterranean ketogenic diet → Waist-to-hip ratio
Very-low-calorie ketogenic diet → Insulin resistance
Very-low-calorie ketogenic diet → Insulin resistance
Very-low-calorie ketogenic diet → Percentage weight loss after 12 weeks
Very-low-calorie ketogenic diet → Percentage weight loss after 12 weeks
Very-low-calorie ketogenic diet → Serum creatinine
Very-low-calorie ketogenic diet → Serum creatinine
Very-low-calorie ketogenic diet → Waist circumference
Very-low-calorie ketogenic diet → Waist circumference
Very-low-calorie ketogenic diet → Waist-to-hip ratio
Very-low-calorie ketogenic diet → Waist-to-hip ratio
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Ketogenic Diets and Insulin Resistance, Ketogenic Diets and Body Composition.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Body Composition
Measures Body Composition as a key outcome.
All studies measuring Insulin Resistance
Measures Insulin Resistance as a key outcome.
All studies on Ketogenic Diets
Contributes to Ketogenic Diets evidence base.
All studies measuring Weight Loss Outcomes
Measures Weight Loss Outcomes as a key outcome.
Latest published studies
Published within the last 2 years.
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3 results
3 results
3 results
3 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
Ketogenic Diets may improve Body Composition.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Waist circumference
EvidenceScore™ Strong | EvidenceScore™ 75.4 | strong positive | ConsistencyScore™ Consistent | 1 study
Waist-to-hip ratio
EvidenceScore™ Emerging | EvidenceScore™ 58.5 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 5 supporting studies with consistent results and a positive effect signal.
Limitations
Ketogenic Diets may improve Insulin Resistance.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Insulin resistance
EvidenceScore™ Strong | EvidenceScore™ 76.7 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Ketogenic Diets appears to improve Weight Loss Outcomes.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Percentage weight loss after 12 weeks
EvidenceScore™ Moderate | EvidenceScore™ 68.8 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Current evidence does not show a clear benefit of Ketogenic Diets for Kidney Function.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Serum creatinine
EvidenceScore™ Emerging | EvidenceScore™ 58.5 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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