Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Whole Food Plant-Based Diet Improves Health in Diabetic Patients
Last updated August 22, 2026
Key finding
Adoption of a WFPB diet led to significant decreases in weight (4.3 kg; p < 0.01).
This pilot study evaluated the implementation of a Whole Food Plant-Based (WFPB) diet in a clinical setting, finding significant reductions in body weight and cholesterol levels.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This pilot study evaluated the implementation of a Whole Food Plant-Based (WFPB) diet in a clinical setting, finding significant reductions in body weight and cholesterol levels.
Clinical relevance
These findings suggest that a Whole Food Plant-Based diet can be an effective intervention for weight management and cholesterol reduction, which are critical factors in preventing cardiovascular diseases. Clinicians may consider recommending this dietary approach to patients seeking to improve their metabolic health.
Keep in mind
Small sample size may limit generalizability Short duration of the study may not capture long-term effects Lack of control group for comparison
Published in
Journal Reference
Publication details and source links for this paper.
Subhas CG, Lindsey AR, Keith ST. Implementation of a Whole Food Plant-Based Diet in a Clinical Setting: A Pilot Study. Journal of Lifestyle Medicine. 2022;12(3):148-152. doi:10.15280/jlm.2022.12.3.148
Main Effects
Significant decrease in body weight by 4.3 kg (p < 0.01)
Significant decrease in total cholesterol by 0.72 mmol/L (p = 0.046)
Significant decrease in triglycerides by 0.53 mmol/L (p = 0.005)
Increase in HDL by 0.10 mmol/L (p = 0.01)
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Mediterranean ketogenic diet and Body weight, C-reactive protein, HDL cholesterol, and 5 more.
This study contributes evidence to
Primary intervention
Mediterranean ketogenic diet
Primary outcomes
- Body weight
- C-reactive protein
- HDL cholesterol
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
8
Evidence pairs
8
Relationships
5
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
5
Related topics
8
Evidence pairs
1218
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 8 evidence relationships
- Includes primary outcome data
- Linked to 5 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Ketogenic Diets and Body Weight
Related evidence
Evidence relationship
Ketogenic Diets and HbA1c
Save evidence
Evidence relationship
Ketogenic Diets and Adipokine and Angiogenic Markers
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
C-reactive protein
Mediterranean ketogenic diet → C-reactive protein
Mediterranean ketogenic diet → C-reactive protein
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerHDL cholesterol
Mediterranean ketogenic diet → HDL cholesterol
Mediterranean ketogenic diet → HDL cholesterol
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerLDL cholesterol
Mediterranean ketogenic diet → LDL cholesterol
Mediterranean ketogenic diet → LDL cholesterol
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerSystolic blood pressure
Mediterranean ketogenic diet → Systolic blood pressure
Mediterranean ketogenic diet → Systolic blood pressure
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerTotal cholesterol
Mediterranean ketogenic diet → Total cholesterol
Mediterranean ketogenic diet → Total cholesterol
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 75
- Positive
- ConsistencyScore™
- 35
- mixed
Supporting studies: Based on 2 studies
Add to Evidence TrackerTriglycerides
Mediterranean ketogenic diet → Triglycerides
Mediterranean ketogenic diet → Triglycerides
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- Body weight decreased by 4.3 kg, indicating effective weight loss.
- Total cholesterol reduced by 0.72 mmol/L, suggesting improved lipid profiles.
- Triglycerides decreased by 0.53 mmol/L, further supporting cardiovascular health.
Who this applies to
- Adults seeking to lose weight
- Individuals with elevated cholesterol levels
- Patients interested in dietary interventions for metabolic health
Keep in Mind
- Results may not apply to populations outside the study group.
- Long-term adherence to the diet was not assessed.
- Further research is needed to confirm findings in larger, diverse populations.
Between the Lines
- Small sample size may limit generalizability
- Short duration of the study may not capture long-term effects
- Lack of control group for comparison
Evidence Library
Build your evidence library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Ketogenic Diets and Adipokine and Angiogenic Markers, Ketogenic Diets and Body Weight.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Ketogenic Diets → Adipokine and Angiogenic Markers
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 75
- Positive
- ConsistencyScore™
- 35
- mixed
Supporting studies: Based on 2 studies
View evidenceDiet and Nutrition
Ketogenic Diets → Body Weight
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceDiet and Nutrition
Ketogenic Diets → Inflammatory Markers
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Adipokine and Angiogenic Markers Evidence Hub
All studies measuring Adipokine and Angiogenic Markers
2 studies
outcome_hubMeasures Adipokine and Angiogenic Markers as a key outcome.
Ketogenic Diets Evidence Hub
All studies on Ketogenic Diets
2 studies
intervention_hubContributes to Ketogenic Diets evidence base.
Body Weight Evidence Hub
All studies measuring Body Weight
1 studies
outcome_hubMeasures Body Weight as a key outcome.
Inflammatory Markers Evidence Hub
All studies measuring Inflammatory Markers
1 studies
outcome_hubMeasures Inflammatory Markers as a key outcome.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Mediterranean ketogenic diet and Total cholesterol
Intervention: Mediterranean ketogenic dietOutcome: Total cholesterol
2 results
All studies on Mediterranean ketogenic diet and Body weight
Intervention: Mediterranean ketogenic dietOutcome: Body weight
1 results
All studies on Mediterranean ketogenic diet
Intervention: Mediterranean ketogenic diet
2 results
All studies measuring Total cholesterol
Outcome: Total cholesterol
2 results
All studies measuring Body weight
Outcome: Body weight
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Ketogenic Diets affect body weight?
Strong Evidence
Ketogenic Diets appears to improve Body Weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Body weight
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does Ketogenic Diets improve HbA1c?
Strong Evidence
Ketogenic Diets may improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does Ketogenic Diets improve adipokine and angiogenic markers?
Strong Evidence
Ketogenic Diets may improve Adipokine and Angiogenic Markers.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The available evidence reports mixed findings.
Ranked evidence signals
- 1
Total cholesterol
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
- 2
HDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
- 3
Triglycerides
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
- Population details are unavailable.
Does Ketogenic Diets improve blood pressure?
Moderate Evidence
Ketogenic Diets may improve Blood Pressure.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The available evidence reports mixed findings.
Ranked evidence signals
- 1
Systolic blood pressure
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
- Only a small number of supporting studies are available.
- Population details are unavailable.
Next steps
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