Last updated September 9, 2026
Key finding
The prevalence of GDM was significantly higher in the one-step group than in the two-step group, with rates of 24/73 (33.3%) vs 8/70 (11.3%); P value 0.002.
This study compared the one-step and two-step methods for diagnosing gestational diabetes mellitus (GDM) and found that the one-step method significantly increased GDM prevalence.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study compared the one-step and two-step methods for diagnosing gestational diabetes mellitus (GDM) and found that the one-step method significantly increased GDM prevalence.
This finding is clinically significant as it suggests that the one-step method may identify more cases of gestational diabetes, which is crucial for managing maternal and fetal health. Early detection and management of GDM can help prevent complications such as macrosomia and preterm birth, ultimately improving outcomes for both mothers and their babies.
Limited sample size may affect the generalizability of the findings. The study did not assess long-term outcomes of increased GDM prevalence. Potential confounding factors were not fully explored.
Published in
Publication details and source links for this paper.
Natthaphon P, Phudit J, Theera T. The one-step method markedly increases the prevalence of gestational diabetes mellitus compared to the two-step method. Journal of Diabetes Investigation. 2024;16(4):728-734. doi:10.1111/jdi.14370
The one-step method resulted in a GDM prevalence of 33.3% compared to 11.3% for the two-step method (P=0.002).
Relative risk for GDM was 2.96, indicating a significant increase with the one-step method.
No significant differences were found in fetal macrosomia, preterm birth, or postpartum hemorrhage rates between the groups.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to One-step method (75-gm 2-h OGTT), Two-step method (50-gm GCT followed by 100-gm OGTT) and Incidence of macrosomia, Postpartum hemorrhage, Prevalence of GDM, and 1 more.
This study contributes evidence to
Primary intervention
One-step method (75-gm 2-h OGTT)
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
8
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
One-step method (75-gm 2-h OGTT) → Incidence of macrosomia
One-step method (75-gm 2-h OGTT) → Incidence of macrosomia
One-step method (75-gm 2-h OGTT) → Postpartum hemorrhage
One-step method (75-gm 2-h OGTT) → Postpartum hemorrhage
One-step method (75-gm 2-h OGTT) → Prevalence of GDM
One-step method (75-gm 2-h OGTT) → Prevalence of GDM
One-step method (75-gm 2-h OGTT) → Rate of preterm delivery (<37 weeks)
One-step method (75-gm 2-h OGTT) → Rate of preterm delivery (<37 weeks)
Two-step method (50-gm GCT followed by 100-gm OGTT) → Incidence of macrosomia
Two-step method (50-gm GCT followed by 100-gm OGTT) → Incidence of macrosomia
Two-step method (50-gm GCT followed by 100-gm OGTT) → Postpartum hemorrhage
Two-step method (50-gm GCT followed by 100-gm OGTT) → Postpartum hemorrhage
Two-step method (50-gm GCT followed by 100-gm OGTT) → Prevalence of GDM
Two-step method (50-gm GCT followed by 100-gm OGTT) → Prevalence of GDM
Two-step method (50-gm GCT followed by 100-gm OGTT) → Rate of preterm delivery (<37 weeks)
Two-step method (50-gm GCT followed by 100-gm OGTT) → Rate of preterm delivery (<37 weeks)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on One-step method (75-gm 2-h OGTT) and Incidence of macrosomia, One-step method (75-gm 2-h OGTT) and Rate of preterm delivery (<37 weeks).
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring Incidence of macrosomia
Measures Incidence of macrosomia as a key outcome.
All studies on One-step method (75-gm 2-h OGTT)
Contributes to One-step method (75-gm 2-h OGTT) evidence base.
All studies measuring Rate of preterm delivery (<37 weeks)
Measures Rate of preterm delivery (<37 weeks) as a key outcome.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
2 results
2 results
2 results
2 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear reduction in incidence of macrosomia with One-step method (75-gm 2-h OGTT).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Incidence of macrosomia
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of One-step method (75-gm 2-h OGTT) for rate of preterm delivery (<37 weeks).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Rate of preterm delivery (<37 weeks)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear reduction in incidence of macrosomia with Two-step method (50-gm GCT followed by 100-gm OGTT).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Incidence of macrosomia
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Two-step method (50-gm GCT followed by 100-gm OGTT) for rate of preterm delivery (<37 weeks).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Rate of preterm delivery (<37 weeks)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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