Last updated September 9, 2026
Key finding
The prevalence of GDM was numerically higher in the one-step 75 g OGTT approach compared with the two-step OGTT approach, but this difference did not reach statistical significance (12.9% vs 11.7%, p = .318).
This study compared two strategies for screening gestational diabetes: a two-step oral glucose tolerance test (OGTT) and a one-step OGTT. The one-step approach showed a numerically higher prevalence of gestational diabetes, but the difference was not statistically significant.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
Save research, organize studies, and quickly find important evidence again.
Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study compared two strategies for screening gestational diabetes: a two-step oral glucose tolerance test (OGTT) and a one-step OGTT. The one-step approach showed a numerically higher prevalence of gestational diabetes, but the difference was not statistically significant.
Understanding the effectiveness of different screening methods for gestational diabetes is crucial for improving maternal and fetal health. Although the one-step approach identified more cases, the lack of statistical significance suggests that both methods are similarly effective in clinical practice. This information can help healthcare providers make informed decisions about screening strategies.
The study did not achieve statistical significance for the primary outcome. Sample size may limit the generalizability of the findings. Potential unmeasured confounders could affect the outcomes.
Published in
Publication details and source links for this paper.
Batuhan T, Uğurcan Z, Harun K, et al. Comparison of Two-Step and One-Step Oral Glucose Tolerance Test Strategies for Gestational Diabetes Screening. Frontiers in Endocrinology. 2026;17:1793806. doi:10.3389/fendo.2026.1793806
Gestational diabetes prevalence was 12.9% in the one-step group vs 11.7% in the two-step group, p = NS.
Polyhydramnios incidence was similar: 6.1% in the one-step vs 6.5% in the two-step, p = 0.742.
Hypertensive disorders incidence was comparable: 5.9% in the one-step vs 6.1% in the two-step, p = 0.801.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to One-step method (75-gm 2-h OGTT), Two-step method (50-gm GCT followed by 100-gm OGTT) and Caesarean section rate, Gestational diabetes mellitus incidence, Hypertensive disorders incidence, and 4 more.
This study contributes evidence to
Primary intervention
One-step method (75-gm 2-h OGTT)
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
14
Evidence pairs
49
Related studies
Evidence topic
Contributes evidence
Save studies and evidence pages, organize your personal Evidence Tracker, and keep the research you care about in one place.
Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
One-step method (75-gm 2-h OGTT) → Caesarean section rate
One-step method (75-gm 2-h OGTT) → Caesarean section rate
One-step method (75-gm 2-h OGTT) → Gestational diabetes mellitus incidence
One-step method (75-gm 2-h OGTT) → Gestational diabetes mellitus incidence
One-step method (75-gm 2-h OGTT) → Hypertensive disorders incidence
One-step method (75-gm 2-h OGTT) → Hypertensive disorders incidence
One-step method (75-gm 2-h OGTT) → Incidence of macrosomia
One-step method (75-gm 2-h OGTT) → Incidence of macrosomia
One-step method (75-gm 2-h OGTT) → Number of NICU admissions
One-step method (75-gm 2-h OGTT) → Number of NICU admissions
One-step method (75-gm 2-h OGTT) → Polyhydramnios incidence
One-step method (75-gm 2-h OGTT) → Polyhydramnios incidence
One-step method (75-gm 2-h OGTT) → Rate of preterm delivery (<37 weeks)
One-step method (75-gm 2-h OGTT) → Rate of preterm delivery (<37 weeks)
Two-step method (50-gm GCT followed by 100-gm OGTT) → Caesarean section rate
Two-step method (50-gm GCT followed by 100-gm OGTT) → Caesarean section rate
Two-step method (50-gm GCT followed by 100-gm OGTT) → Gestational diabetes mellitus incidence
Two-step method (50-gm GCT followed by 100-gm OGTT) → Gestational diabetes mellitus incidence
Two-step method (50-gm GCT followed by 100-gm OGTT) → Hypertensive disorders incidence
Two-step method (50-gm GCT followed by 100-gm OGTT) → Hypertensive disorders incidence
Two-step method (50-gm GCT followed by 100-gm OGTT) → Incidence of macrosomia
Two-step method (50-gm GCT followed by 100-gm OGTT) → Incidence of macrosomia
Two-step method (50-gm GCT followed by 100-gm OGTT) → Number of NICU admissions
Two-step method (50-gm GCT followed by 100-gm OGTT) → Number of NICU admissions
Two-step method (50-gm GCT followed by 100-gm OGTT) → Polyhydramnios incidence
Two-step method (50-gm GCT followed by 100-gm OGTT) → Polyhydramnios incidence
Two-step method (50-gm GCT followed by 100-gm OGTT) → Rate of preterm delivery (<37 weeks)
Two-step method (50-gm GCT followed by 100-gm OGTT) → Rate of preterm delivery (<37 weeks)
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on One-step method (75-gm 2-h OGTT) and Incidence of macrosomia, One-step method (75-gm 2-h OGTT) and Rate of preterm delivery (<37 weeks).
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring Incidence of macrosomia
Measures Incidence of macrosomia as a key outcome.
All studies on One-step method (75-gm 2-h OGTT)
Contributes to One-step method (75-gm 2-h OGTT) evidence base.
All studies measuring Rate of preterm delivery (<37 weeks)
Measures Rate of preterm delivery (<37 weeks) as a key outcome.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
2 results
2 results
2 results
2 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear reduction in incidence of macrosomia with One-step method (75-gm 2-h OGTT).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Incidence of macrosomia
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of One-step method (75-gm 2-h OGTT) for rate of preterm delivery (<37 weeks).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Rate of preterm delivery (<37 weeks)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear reduction in incidence of macrosomia with Two-step method (50-gm GCT followed by 100-gm OGTT).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Incidence of macrosomia
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Two-step method (50-gm GCT followed by 100-gm OGTT) for rate of preterm delivery (<37 weeks).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Rate of preterm delivery (<37 weeks)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Next steps
Choose a next path through related evidence topics, Evidence Explorer views, and research summaries.
Open broader Evidence Explorer views for this relationship.
Read related research summaries.
Focused on evidence, not advertising.
Your data is always protected.
New studies added every day.
