Last updated July 17, 2026
Key finding
Primary outcome is diabetes remission (HbA1c <6.5% without glucose-lowering medication for ≥3 months).
The REPAIR trial investigated the effects of a plant-based lifestyle intervention on diabetes remission and weight loss. Results showed no significant differences compared to standard care.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
The REPAIR trial investigated the effects of a plant-based lifestyle intervention on diabetes remission and weight loss. Results showed no significant differences compared to standard care.
Understanding the effectiveness of dietary interventions for diabetes management is crucial for developing effective treatment plans. The findings suggest that while plant-based diets may be popular, they may not offer additional benefits over standard care for achieving diabetes remission or significant weight loss, highlighting the need for further research in this area.
The effectiveness of the interventions remains unclear due to lack of significant findings. Limited generalizability as the study population may not represent all diabetes patients. Potential unmeasured confounders could have influenced the outcomes.
Published in
Publication details and source links for this paper.
Brighid M, Dayana EC, Melanie P, et al. The REmission of diabetes using a PlAnt-based weight loss InteRvention (REPAIR) trial. Diabetes, Obesity & Metabolism. 2026;28(4):2627-2641. doi:10.1111/dom.70510
No significant difference in diabetes remission rates compared to standard care.
No significant difference in the proportion achieving ≥15% weight loss compared to standard care.
Evidence network
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This study contributes evidence to Lifestyle intervention for prediabetes, Usual care and Diabetes remission, Proportion of participants achieving weight loss of 15% or more at 52 weeks.
This study contributes evidence to
Primary intervention
Lifestyle intervention for prediabetes
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
4
Evidence pairs
189
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Lifestyle intervention for prediabetes → Diabetes remission
Lifestyle intervention for prediabetes → Diabetes remission
Lifestyle intervention for prediabetes → Proportion of participants achieving weight loss of 15% or more at 52 weeks
Lifestyle intervention for prediabetes → Proportion of participants achieving weight loss of 15% or more at 52 weeks
Usual care → Proportion of participants achieving weight loss of 15% or more at 52 weeks
Usual care → Proportion of participants achieving weight loss of 15% or more at 52 weeks
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Usual care and Diabetes remission, Lifestyle intervention for prediabetes and Diabetes remission.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring Diabetes remission
Measures Diabetes remission as a key outcome.
All studies on Usual care
Contributes to Usual care evidence base.
All studies on Lifestyle intervention for prediabetes
Contributes to Lifestyle intervention for prediabetes evidence base.
All studies measuring Proportion of participants achieving weight loss of 15% or more at 52 weeks
Measures Proportion of participants achieving weight loss of 15% or more at 52 weeks as a key outcome.
Latest published studies
Published within the last 2 years.
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2 results
1 results
2 results
1 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear benefit of Usual care for Diabetes remission.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Diabetes remission
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Usual care for Proportion of participants achieving weight loss of 15% or more at 52 weeks.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Proportion of participants achieving weight loss of 15% or more at 52 weeks
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Lifestyle intervention for prediabetes may worsen Diabetes remission or be associated with harm.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Diabetes remission
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | moderate negative | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Lifestyle intervention for prediabetes may worsen Proportion of participants achieving weight loss of 15% or more at 52 weeks or be associated with harm.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Proportion of participants achieving weight loss of 15% or more at 52 weeks
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | moderate negative | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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