Last updated September 2, 2026
Key finding
The estimated difference between HN001-placebo capsules was -0.83, 95% CI -1.93 to 0.27 mmol/mol, p=0.63.
This study evaluated the effects of Lactobacillus rhamnosus HN001 and oat-derived beta-glucan on adults with pre-diabetes, finding no significant differences in key metabolic outcomes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
High Risk
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effects of Lactobacillus rhamnosus HN001 and oat-derived beta-glucan on adults with pre-diabetes, finding no significant differences in key metabolic outcomes.
Understanding the effectiveness of dietary interventions in pre-diabetes is crucial for developing strategies to prevent diabetes. This study suggests that Lactobacillus rhamnosus HN001 and oat-derived beta-glucan may not provide the expected benefits for metabolic health in this population.
The study may have limited generalizability due to a specific participant demographic. The sample size may not have been large enough to detect small but clinically relevant effects. The duration of the study may have been insufficient to observe long-term benefits.
Published in
Publication details and source links for this paper.
Christine B, Fiona H, Julian C, et al. Effect of Lactobacillus rhamnosus HN001 and Oat-Derived Beta-Glucan on Adults with Pre-Diabetes: A Randomized Controlled Trial. BMJ Open. 2022;12(3):e055214. doi:10.1136/bmjopen-2021-055214
HbA1c levels at 6 months showed no significant difference (mean 45.9 vs 46.7 mmol/mol, p=0.63).
No differences were found in fasting plasma glucose levels between groups.
No significant changes were observed in fasting insulin levels or body weight.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Lactobacillus rhamnosus HN001 capsules with OBG cereal and BMI, Body weight, Fasting Plasma Glucose (FPG), and 7 more.
This study contributes evidence to
Primary intervention
Lactobacillus rhamnosus HN001 capsules with OBG cereal
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
5
Related topics
10
Evidence pairs
1546
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Lactobacillus rhamnosus HN001 capsules with OBG cereal → BMI
Lactobacillus rhamnosus HN001 capsules with OBG cereal → BMI
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Body weight
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Body weight
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Fasting insulin levels
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Fasting insulin levels
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Fasting lipids
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Fasting lipids
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Fasting Plasma Glucose (FPG)
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Fasting Plasma Glucose (FPG)
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Homeostatic model assessment (HOMA2-B)
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Homeostatic model assessment (HOMA2-B)
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Improvement in Well-Being
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Improvement in Well-Being
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Percentage of patients with HbA1c > 8.5% after 3 months
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Percentage of patients with HbA1c > 8.5% after 3 months
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Systolic blood pressure
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Systolic blood pressure
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Waist circumference
Lactobacillus rhamnosus HN001 capsules with OBG cereal → Waist circumference
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Lactobacillus rhamnosus HN001 capsules with OBG cereal and Body Mass Index, Lactobacillus rhamnosus HN001 capsules with OBG cereal and Body Weight.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Body Mass Index
Measures Body Mass Index as a key outcome.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
All studies measuring Fasting lipids
Measures Fasting lipids as a key outcome.
All studies on Lactobacillus rhamnosus HN001 capsules with OBG cereal
Contributes to Lactobacillus rhamnosus HN001 capsules with OBG cereal evidence base.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear effect of Lactobacillus rhamnosus HN001 capsules with OBG cereal on BMI.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
BMI
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear effect of Lactobacillus rhamnosus HN001 capsules with OBG cereal on body weight.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Body weight
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Lactobacillus rhamnosus HN001 capsules with OBG cereal for fasting plasma glucose (FPG).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Lactobacillus rhamnosus HN001 capsules with OBG cereal for fasting insulin levels.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting insulin levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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