Last updated July 3, 2026
Key finding
β-cell function increased from 42.2 ± 15.4 to 62.21 ± 33.98; r=0.049
BL21 probiotic added to metformin in adults with type 2 diabetes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
BL21 probiotic added to metformin in adults with type 2 diabetes.
This study evaluated BL21 probiotic added to metformin in adults with type 2 diabetes.
Limitations were not clearly described in the extracted text.
Published in
Publication details and source links for this paper.
Maryana S, Dmytro K, Galyna M, Olena T, Tatyana F, Nazarii K. The effectiveness of live multistrain probiotic co-supplementation with omega-3 PUFAs vs. placebo on β-cell function in T2D patients. Scientific Reports. 2025;15:33870. doi:10.1038/s41598-025-07861-2
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Probiotic-Omega and Anthropometric parameters, Beta-cell function, Fasting Plasma Glucose (FPG), and 1 more.
This study contributes evidence to
Primary intervention
Probiotic-Omega
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
4
Evidence pairs
156
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
The primary outcomes reported in this study.
Probiotic-Omega → Anthropometric parameters
Probiotic-Omega → Anthropometric parameters
Probiotic-Omega → Fasting Plasma Glucose (FPG)
Probiotic-Omega → Fasting Plasma Glucose (FPG)
Probiotic-Omega → Tumor Necrosis Factor-alpha (TNF-α)
Probiotic-Omega → Tumor Necrosis Factor-alpha (TNF-α)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Probiotics and Synbiotics and Body Composition, Probiotics and Synbiotics and Beta-cell Function.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Curated evidence collections and hubs this study is part of.
All studies measuring Beta-cell Function
Measures Beta-cell Function as a key outcome.
All studies measuring Body Composition
Measures Body Composition as a key outcome.
All studies on Probiotics and Synbiotics
Contributes to Probiotics and Synbiotics evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Probiotics and Synbiotics may improve Fasting Glucose.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 9 supporting studies with generally consistent results and a positive effect signal.
Limitations
Probiotics and Synbiotics may improve Inflammatory Markers.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Tumor Necrosis Factor-alpha (TNF-α)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 3 supporting studies with generally consistent results and a positive effect signal.
Limitations
Probiotics and Synbiotics may improve Body Composition.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Anthropometric parameters
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a small number of supporting studies and should be interpreted cautiously.
Limitations
Probiotics and Synbiotics appears to improve Beta-cell Function.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Beta-cell function
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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