Key finding
HOMA-IR decreased by 0.66 from baseline to 12 weeks (p=0.006).
Probiotic supplementation significantly improved insulin resistance and other metabolic markers in diabetic patients undergoing hemodialysis.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Extended (5–20+ y)
Quick read
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Probiotic supplementation, Placebo
Study type
RCTs
Follow-up
Extended (5–20+ y)
Primary outcome
Insulin resistance
Comparator
Group B
Plain-language summary
A plain-language read of the study's main message and where it applies.
Study focus
Probiotic supplementation significantly improved insulin resistance and other metabolic markers in diabetic patients undergoing hemodialysis.
These findings suggest that probiotics could be a beneficial adjunct therapy for managing diabetes in patients undergoing hemodialysis, potentially leading to improved metabolic health and reduced complications associated with diabetes and kidney disease.
Limited sample size may affect generalizability. Short duration of the study limits long-term conclusions. Lack of detailed demographic data on participants.
Published in
Publication details and source links for this paper.
Alexander M, John RA, Usharani P, Raja KK, Padmaja M, Imran K. Probiotic Supplementation Improves Insulin Resistance in Diabetic Patients on Hemodialysis. Cureus. 2024;16(11):e74621. doi:10.7759/cureus.74621
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Insulin resistance (HOMA-IR) decreased by 0.66 in the probiotic group (p=0.006).
Malondialdehyde (MDA) decreased by 0.92 μmol/L in the probiotic group (p=0.001).
Nitric oxide (NO) increased by 6.16 μmol/L in the probiotic group (p=0.004).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Multispecies probiotic supplementation and Fasting blood sugar (FBS), Glutathione (GSH), HbA1c, and 3 more.
This study contributes evidence to
Primary intervention
Multispecies probiotic supplementation
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
4
Related topics
6
Evidence pairs
312
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
The primary outcomes reported in this study.
Multispecies probiotic supplementation → Fasting blood sugar (FBS)
Multispecies probiotic supplementation → Fasting blood sugar (FBS)
Evidence profile
Multispecies probiotic supplementation → Glutathione (GSH)
Multispecies probiotic supplementation → Glutathione (GSH)
Evidence profile
Multispecies probiotic supplementation → HbA1c
Multispecies probiotic supplementation → HbA1c
Evidence profile
Multispecies probiotic supplementation → Insulin resistance
Multispecies probiotic supplementation → Insulin resistance
Evidence profile
Multispecies probiotic supplementation → Malondialdehyde (MDA)
Multispecies probiotic supplementation → Malondialdehyde (MDA)
Evidence profile
Multispecies probiotic supplementation → Nitric Oxide (NO)
Multispecies probiotic supplementation → Nitric Oxide (NO)
Evidence profile
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Probiotics and Synbiotics and HbA1c, Probiotics and Synbiotics and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Probiotics and Synbiotics
Contributes to Probiotics and Synbiotics evidence base.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
Latest published studies
Published within the last 2 years.
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2 results
1 results
2 results
2 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Probiotics and Synbiotics appears to improve Endothelial Biomarkers.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Nitric Oxide (NO)
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Probiotics and Synbiotics appears to improve Oxidative Stress Markers.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Malondialdehyde (MDA)
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Probiotics and Synbiotics appears to improve HbA1c.
ConsensusScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 57.1 | strong positive | ConsensusScore™ Consistent | 1 study
Why this answer: This answer is based on 10 supporting studies with consistent results and a positive effect signal.
Limitations
Probiotics and Synbiotics may improve Fasting Glucose.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting blood sugar (FBS)
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on 9 supporting studies and existing graph evidence signals.
Limitations
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