NoneNo Change
Blood glucose
Multispecies probiotic supplementation → Blood glucose
Multispecies probiotic supplementation → Blood glucose
Evidence profile
NoneNo ChangeGlycemic Control
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Research Summary
Analyzed using Evidence Intelligence™
Probiotics may improve glycemic control in type 2 diabetes
Key finding
HbA1c decreased significantly in the probiotic group (p=0.004).
This study investigated the effects of multispecies probiotic supplementation on glycemic control in individuals with type 2 diabetes over 24 weeks, finding significant reductions in HbA1c and increases in HDL-c.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Some Concerns bias
Last updated July 3, 2026Quick read
Study at a glance
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Multispecies probiotic supplementation, Placebo
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Primary outcome
Fasting blood glucose (FBG)
Comparator
Placebo Group
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
This study investigated the effects of multispecies probiotic supplementation on glycemic control in individuals with type 2 diabetes over 24 weeks, finding significant reductions in HbA1c and increases in HDL-c.
Clinical relevance
These findings are clinically significant as they suggest that probiotic supplementation could be a beneficial adjunct therapy for managing glycemic control and improving lipid profiles in patients with type 2 diabetes. This could lead to better overall health outcomes and reduced risk of diabetes-related complications.
Keep in mind
The study had a relatively small sample size, which may limit generalizability. The duration of the study was only 24 weeks, which may not capture long-term effects. Some outcomes showed trends but were not statistically significant, indicating uncertainty.
Published in
Journal Reference
Publication details and source links for this paper.
Venkata C, Janardanan K, Kakithakara VL, Mohan R, Jayaprakash T, Grigorios P. The Impact of Multistrain Probiotic Supplementation on Glycemic Control in Type 2 Diabetes Mellitus: A 24-Week Randomized Controlled Trial. Life. 2024;14(11):1484. doi:10.3390/life14111484
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Main Effects
HbA1c decreased significantly in the probiotic group (p=0.004)
HDL-c increased significantly in the probiotic group (p<0.001)
Total cholesterol showed no significant change (p=0.556)
Triglycerides showed no significant change (p=0.233)
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Multispecies probiotic supplementation and Blood glucose, HDL cholesterol, HbA1c, and 4 more.
This study contributes evidence to
Primary intervention
Multispecies probiotic supplementation
Primary outcomes
- Blood glucose
- HDL cholesterol
- HbA1c
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
7
Evidence pairs
7
Relationships
3
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
3
Related topics
7
Evidence pairs
284
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 7 evidence relationships
- Includes primary outcome data
- Linked to 3 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
Study findings
The primary outcomes reported in this study.
StrongDecrease
HbA1c
Multispecies probiotic supplementation → HbA1c
Multispecies probiotic supplementation → HbA1c
Evidence profile
StrongDecreaseGlycemic Control
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StrongIncrease
HDL cholesterol
Multispecies probiotic supplementation → HDL cholesterol
Multispecies probiotic supplementation → HDL cholesterol
Evidence profile
StrongIncreaseMetabolic Health
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NoneNo Change
LDL cholesterol
Multispecies probiotic supplementation → LDL cholesterol
Multispecies probiotic supplementation → LDL cholesterol
Evidence profile
NoneNo ChangeMetabolic Health
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NoneNo Change
Postprandial blood glucose
Multispecies probiotic supplementation → Postprandial blood glucose
Multispecies probiotic supplementation → Postprandial blood glucose
Evidence profile
NoneNo ChangeGlycemic Control
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NoneNo Change
Total cholesterol
Multispecies probiotic supplementation → Total cholesterol
Multispecies probiotic supplementation → Total cholesterol
Evidence profile
NoneNo ChangeMetabolic Health
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NoneNo Change
Triglycerides
Multispecies probiotic supplementation → Triglycerides
Multispecies probiotic supplementation → Triglycerides
Evidence profile
NoneNo ChangeMetabolic Health
Unlock full evidence details
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Evidence Suggest
- HbA1c decreased by 0.44% in the probiotic group (p=0.004).
- HDL-c increased by 3.33 mg/dL in the probiotic group (p=0.023).
- No significant changes were observed in total cholesterol and triglycerides.
Who this applies to
- Adults diagnosed with type 2 diabetes.
- Individuals seeking adjunct therapies for glycemic control.
Keep in Mind
- Results may not apply to populations outside the study's demographic.
- The study did not assess long-term effects beyond 24 weeks.
- Further research is needed to confirm findings and explore mechanisms.
Between the Lines
- The study had a relatively small sample size, which may limit generalizability.
- The duration of the study was only 24 weeks, which may not capture long-term effects.
- Some outcomes showed trends but were not statistically significant, indicating uncertainty.
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Probiotics and Synbiotics and HbA1c, Probiotics and Synbiotics and Adipokine and Angiogenic Markers.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
HbA1c Evidence Hub
All studies measuring HbA1c
2 studies
outcome_hubMeasures HbA1c as a key outcome.
Probiotics and Synbiotics Evidence Hub
All studies on Probiotics and Synbiotics
2 studies
intervention_hubContributes to Probiotics and Synbiotics evidence base.
Adipokine and Angiogenic Markers Evidence Hub
All studies measuring Adipokine and Angiogenic Markers
1 studies
outcome_hubMeasures Adipokine and Angiogenic Markers as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Multispecies probiotic supplementation and HbA1c
Intervention: Multispecies probiotic supplementationOutcome: HbA1c
2 results
All studies on Multispecies probiotic supplementation and HDL cholesterol
Intervention: Multispecies probiotic supplementationOutcome: HDL cholesterol
1 results
All studies on Multispecies probiotic supplementation
Intervention: Multispecies probiotic supplementation
2 results
All studies measuring HbA1c
Outcome: HbA1c
2 results
All studies measuring HDL cholesterol
Outcome: HDL cholesterol
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Probiotics and Synbiotics improve HbA1c?
Emerging Evidence
Probiotics and Synbiotics appears to improve HbA1c.
ConsensusScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 57.1 | strong positive | ConsensusScore™ Consistent | 1 study
Why this answer: This answer is based on 10 supporting studies with consistent results and a positive effect signal.
Limitations
- Population details are unavailable.
Does Probiotics and Synbiotics improve fasting glucose?
Emerging Evidence
Probiotics and Synbiotics may improve Fasting Glucose.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Blood glucose
EvidenceScore™ Limited | EvidenceScore™ 35.5 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on 9 supporting studies and existing graph evidence signals.
Limitations
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Probiotics and Synbiotics improve adipokine and angiogenic markers?
Limited Evidence
Current evidence does not show a clear benefit of Probiotics and Synbiotics for Adipokine and Angiogenic Markers.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
HDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 53.0 | strong positive | ConsensusScore™ Unclear | 1 study
- 2
LDL cholesterol
EvidenceScore™ Limited | EvidenceScore™ 35.5 | neutral | ConsensusScore™ Unclear | 1 study
- 3
Total cholesterol
EvidenceScore™ Limited | EvidenceScore™ 35.5 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on 9 supporting studies and existing graph evidence signals.
Limitations
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Probiotics and Synbiotics improve postprandial and ogtt glucose?
Limited Evidence
Current evidence does not show a clear benefit of Probiotics and Synbiotics for Postprandial and OGTT Glucose.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Postprandial blood glucose
EvidenceScore™ Limited | EvidenceScore™ 35.5 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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