Last updated September 4, 2026
Key finding
Participants who received retatrutide 0.5 mg reported greater reductions from baseline in overall appetite compared to placebo.
Higher doses of retatrutide significantly reduced perceived hunger and overall appetite in adults with type 2 diabetes compared to placebo.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
Higher doses of retatrutide significantly reduced perceived hunger and overall appetite in adults with type 2 diabetes compared to placebo.
Managing hunger and appetite is crucial for individuals with type 2 diabetes, as it can help in controlling weight and improving metabolic health. The findings suggest that retatrutide could be a valuable treatment option for enhancing appetite control and supporting weight loss efforts in this population.
Limited sample size may affect generalizability. Short duration of the study may not capture long-term effects. Lack of diverse population representation.
Published in
Publication details and source links for this paper.
Chisom K, Kristina SB, Jiat LP, et al. Perceived hunger and tendency to overeat reduced with higher doses of retatrutide in adults with type 2 diabetes. Diabetes, Obesity & Metabolism. 2025;27(12):6988-6998. doi:10.1111/dom.70097
Retatrutide 0.5 mg reduced overall appetite by -10.5 VAS score (p=0.01).
Retatrutide 4 mg reduced overall appetite by -12 VAS score (p=0.01).
Retatrutide 12 mg reduced overall appetite by -18 VAS score (p=0.01).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Retatrutide 0.5 mg, Retatrutide 12 mg, Retatrutide 4 mg, and 1 more and Eating Inventory Disinhibition, Eating Inventory Perceived Hunger, Hunger scores, and 3 more.
This study contributes evidence to
Primary intervention
Retatrutide 0.5 mg
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
21
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Retatrutide 0.5 mg → Eating Inventory Disinhibition
Retatrutide 0.5 mg → Eating Inventory Disinhibition
Retatrutide 0.5 mg → Eating Inventory Perceived Hunger
Retatrutide 0.5 mg → Eating Inventory Perceived Hunger
Retatrutide 0.5 mg → Prospective food consumption ratings
Retatrutide 0.5 mg → Prospective food consumption ratings
Retatrutide 12 mg → Eating Inventory Disinhibition
Retatrutide 12 mg → Eating Inventory Disinhibition
Retatrutide 12 mg → Eating Inventory Perceived Hunger
Retatrutide 12 mg → Eating Inventory Perceived Hunger
Retatrutide 12 mg → Prospective food consumption ratings
Retatrutide 12 mg → Prospective food consumption ratings
Retatrutide 4 mg → Eating Inventory Disinhibition
Retatrutide 4 mg → Eating Inventory Disinhibition
Retatrutide 4 mg → Eating Inventory Perceived Hunger
Retatrutide 4 mg → Eating Inventory Perceived Hunger
Retatrutide 4 mg → Prospective food consumption ratings
Retatrutide 4 mg → Prospective food consumption ratings
Retatrutide 8 mg → Eating Inventory Disinhibition
Retatrutide 8 mg → Eating Inventory Disinhibition
Retatrutide 8 mg → Eating Inventory Perceived Hunger
Retatrutide 8 mg → Eating Inventory Perceived Hunger
Retatrutide 8 mg → Prospective food consumption ratings
Retatrutide 8 mg → Prospective food consumption ratings
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Retatrutide 0.5 mg and Eating Inventory Disinhibition, Retatrutide 0.5 mg and Eating Inventory Perceived Hunger.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Eating Inventory Disinhibition
Measures Eating Inventory Disinhibition as a key outcome.
All studies measuring Eating Inventory Perceived Hunger
Measures Eating Inventory Perceived Hunger as a key outcome.
All studies on Retatrutide 0.5 mg
Contributes to Retatrutide 0.5 mg evidence base.
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Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Retatrutide 0.5 mg appears to improve eating inventory disinhibition.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Eating Inventory Disinhibition
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Retatrutide 0.5 mg appears to improve eating inventory perceived hunger.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Eating Inventory Perceived Hunger
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Retatrutide 0.5 mg appears to improve hunger scores.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Hunger scores
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Retatrutide 0.5 mg appears to improve overall appetite.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Overall appetite
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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