Last updated July 12, 2026
Key finding
BMAL1 expression increased by 1.8-fold (p = 0.0003).
Dairy-enriched diet vs non-dairy isoenergetic diet in adults with type 2 diabetes.
Quick read
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EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
Dairy-enriched diet vs non-dairy isoenergetic diet in adults with type 2 diabetes.
This study evaluated Dairy-enriched diet vs non-dairy isoenergetic diet in adults with type 2 diabetes.
Limitations were not clearly described in the extracted text.
Published in
Publication details and source links for this paper.
Shani T, Oren F, Yael M, et al. A dairy-enriched diet aligned with structured meal timing enhances circadian clock gene expression and improves glycaemic management in individuals with type 2 diabetes. Diabetologia. 2026;69(4):1021-1034. doi:10.1007/s00125-025-06658-2
Evidence network
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This study contributes evidence to YesMilk diet and BMAL1 gene expression increase, CRY1 gene expression increase, Fasting Plasma Glucose (FPG), and 5 more.
This study contributes evidence to
Primary intervention
YesMilk diet
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
8
Evidence pairs
171
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Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
YesMilk diet → BMAL1 gene expression increase
YesMilk diet → BMAL1 gene expression increase
YesMilk diet → CRY1 gene expression increase
YesMilk diet → CRY1 gene expression increase
YesMilk diet → Fasting Plasma Glucose (FPG)
YesMilk diet → Fasting Plasma Glucose (FPG)
YesMilk diet → Glucose management indicator (GMI)
YesMilk diet → Glucose management indicator (GMI)
YesMilk diet → REV-ERBα gene expression
YesMilk diet → REV-ERBα gene expression
Evidence Library
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Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on YesMilk diet and BMAL1 gene expression increase, YesMilk diet and CRY1 gene expression increase.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring BMAL1 gene expression increase
Measures BMAL1 gene expression increase as a key outcome.
All studies measuring CRY1 gene expression increase
Measures CRY1 gene expression increase as a key outcome.
All studies on YesMilk diet
Contributes to YesMilk diet evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
YesMilk diet appears to improve BMAL1 gene expression increase.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
BMAL1 gene expression increase
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
YesMilk diet appears to improve CRY1 gene expression increase.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
CRY1 gene expression increase
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
YesMilk diet appears to improve Fasting Plasma Glucose (FPG).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
YesMilk diet appears to improve Glucose management indicator (GMI).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Glucose management indicator (GMI)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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