Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Semaglutide improves glycemic control more than insulin aspart in type 2 diabetes
Last updated July 5, 2026
Key finding
HbA1c decreased by 1.5% points (16.6 mmol/mol).
This study compared once-weekly semaglutide to thrice-daily insulin aspart in adults with type 2 diabetes, revealing significant differences in HbA1c and body weight outcomes.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study compared once-weekly semaglutide to thrice-daily insulin aspart in adults with type 2 diabetes, revealing significant differences in HbA1c and body weight outcomes.
Clinical relevance
These findings are significant as they suggest that once-weekly semaglutide may offer a more effective treatment option for adults with type 2 diabetes, leading to better management of blood sugar levels and weight loss. This could improve patient adherence to treatment and overall health outcomes, reducing the risk of diabetes-related complications.
Keep in mind
The study did not report on long-term effects beyond the trial duration. Sample size and demographic diversity may limit generalizability. The study did not explore patient adherence to medication.
Published in
Journal Reference
Publication details and source links for this paper.
Monika K, Margit SK, Jack L, et al. Once-Weekly Semaglutide versus Thrice-Daily Insulin Aspart in Adults with Type 2 Diabetes: A Randomized Trial. Diabetes, Obesity & Metabolism. 2022;24(9):1788-1799. doi:10.1111/dom.14765
Main Effects
HbA1c decreased by 1.5% points (16.6 mmol/mol) with semaglutide, p-value 0.0001.
HbA1c decreased by 1.2% points (13.4 mmol/mol) with insulin aspart, p-value 0.0001.
Body weight decreased by 4.1 kg with semaglutide.
Body weight increased by 2.8 kg with insulin aspart.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Insulin aspart, Semaglutide and Body weight, HbA1c, Severe hypoglycemia.
This study contributes evidence to
Primary intervention
Insulin aspart
Primary outcomes
- Body weight
- HbA1c
- Severe hypoglycemia
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
6
Evidence pairs
6
Relationships
3
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
3
Related topics
6
Evidence pairs
1079
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 6 evidence relationships
- Includes primary outcome data
- Linked to 3 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
GLP-1 Receptor Agonists and HbA1c
Related evidence
Evidence relationship
GLP-1 Receptor Agonists and Body Weight
Save evidence
Evidence relationship
GLP-1 Receptor Agonists and Hypoglycemia
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 75
- Positive
- ConsistencyScore™
- 35
- mixed
Supporting studies: Based on 2 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 76
- Positive
- ConsistencyScore™
- 92
- consistent
Supporting studies: Based on 13 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 88
- Strong
- ImpactScore™
- 87
- Very Positive
- ConsistencyScore™
- 88
- consistent
Supporting studies: Based on 16 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- Semaglutide reduced HbA1c by 1.5% points, significantly more than insulin aspart.
- Participants on semaglutide lost an average of 4.1 kg, while those on insulin gained weight.
- Both treatments had similar rates of severe hypoglycaemic episodes.
Who this applies to
- Adults diagnosed with type 2 diabetes.
- Patients requiring pharmacological management of blood sugar levels.
Keep in Mind
- Results may not apply to populations outside the study's demographic.
- The trial duration may not reflect long-term treatment outcomes.
- Further studies are needed to assess adherence and real-world effectiveness.
Between the Lines
- The study did not report on long-term effects beyond the trial duration.
- Sample size and demographic diversity may limit generalizability.
- The study did not explore patient adherence to medication.
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on GLP-1 Receptor Agonists and HbA1c, GLP-1 Receptor Agonists and Body Weight.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Medications
GLP-1 Receptor Agonists → HbA1c
Medications
Evidence Intelligence™
- EvidenceScore™
- 88
- Strong
- ImpactScore™
- 87
- Very Positive
- ConsistencyScore™
- 88
- consistent
Supporting studies: Based on 16 studies
View evidenceMedications
GLP-1 Receptor Agonists → Body Weight
Medications
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 76
- Positive
- ConsistencyScore™
- 92
- consistent
Supporting studies: Based on 13 studies
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
GLP-1 Receptor Agonists Evidence Hub
All studies on GLP-1 Receptor Agonists
16 studies
intervention_hubContributes to GLP-1 Receptor Agonists evidence base.
HbA1c Evidence Hub
All studies measuring HbA1c
16 studies
outcome_hubMeasures HbA1c as a key outcome.
Body Weight Evidence Hub
All studies measuring Body Weight
13 studies
outcome_hubMeasures Body Weight as a key outcome.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Semaglutide and HbA1c
Intervention: SemaglutideOutcome: HbA1c
16 results
All studies on Semaglutide and Body weight
Intervention: SemaglutideOutcome: Body weight
13 results
All studies on Semaglutide
Intervention: Semaglutide
16 results
All studies measuring HbA1c
Outcome: HbA1c
16 results
All studies measuring Body weight
Outcome: Body weight
13 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Do GLP-1 Receptor Agonists lower HbA1c?
Strong Evidence
GLP-1 Receptor Agonists appear to lower HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 88.2 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 45 supporting studies with consistent results and a positive effect signal.
Do GLP-1 Receptor Agonists affect body weight?
Strong Evidence
GLP-1 Receptor Agonists may affect body weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Body weight
EvidenceScore™ Strong | EvidenceScore™ 85.8 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 43 supporting studies with consistent results and a positive effect signal.
Do GLP-1 Receptor Agonists affect hypoglycemia?
Strong Evidence
GLP-1 Receptor Agonists may affect hypoglycemia.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Severe hypoglycemia
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 14 supporting studies with consistent results and a positive effect signal.
Does Insulin aspart lower HbA1c?
Moderate Evidence
Insulin aspart may lower HbA1c.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The available evidence reports mixed findings.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
- Only one supporting study is available.
Next steps
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