Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Combining Exercise and Polyphenols Improves Glycemic Control in Prediabetes
Last updated July 18, 2026
Key finding
FBG decreased significantly in the CBT + EATME group compared with placebo (p < 0.01).
This study investigated the effects of concurrent training and microencapsulated polyphenol supplementation on glycemic control in adults with prediabetes, finding significant improvements in several health markers.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of concurrent training and microencapsulated polyphenol supplementation on glycemic control in adults with prediabetes, finding significant improvements in several health markers.
Clinical relevance
These findings highlight the potential for integrated lifestyle interventions in managing prediabetes, which is crucial given the rising prevalence of diabetes. Effective strategies that combine physical activity with nutritional support could help mitigate the progression to type 2 diabetes and improve overall health outcomes.
Keep in mind
The study's sample size and demographic diversity may limit generalizability. The long-term effects of the interventions were not assessed. Potential confounding factors were not fully controlled.
Published in
Journal Reference
Publication details and source links for this paper.
Udomlak S, Prapassorn R, Ketsaree K, et al. Synergistic Effects of Concurrent Training and Microencapsulated Polyphenol Supplementation on Glycemic Control in Adults with Prediabetes. Nutrients. 2025;17(21):3358. doi:10.3390/nu17213358
Main Effects
Fasting blood glucose decreased by 5.8 mg/dL in the CBT + EATME group (p < 0.01).
HbA1c decreased by 0.5% in the CBT + EATME group (p < 0.05).
HOMA-IR decreased significantly in the CBT + EATME group (p < 0.01).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Exercise therapy and Adiponectin, C-reactive protein, Fasting blood sugar (FBS), and 6 more.
This study contributes evidence to
Primary intervention
Exercise therapy
Primary outcomes
- Adiponectin
- C-reactive protein
- Fasting blood sugar (FBS)
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
9
Evidence pairs
9
Relationships
7
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 72
7
Related topics
9
Evidence pairs
1150
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 9 evidence relationships
- Includes primary outcome data
- Linked to 7 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Diabetic Neuropathy
matched_intervention_and_outcome
Related evidence
Evidence topic
Diabetic Retinopathy
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 75
- Positive
- ConsistencyScore™
- 35
- mixed
Supporting studies: Based on 2 studies
Add to Evidence TrackerFasting blood sugar (FBS)
Exercise therapy → Fasting blood sugar (FBS)
Exercise therapy → Fasting blood sugar (FBS)
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 81
- Strong
- ImpactScore™
- 84
- Positive
- ConsistencyScore™
- 83
- consistent
Supporting studies: Based on 6 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 88
- Very Positive
- ConsistencyScore™
- 75
- consistent
Supporting studies: Based on 4 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 67
- generally_consistent
Supporting studies: Based on 3 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Evidence Suggest
- hs-CRP decreased significantly in all intervention groups (p < 0.01).
- IL-6 levels decreased significantly in all intervention groups (p < 0.01).
- Adiponectin increased significantly in all intervention groups (p < 0.01).
Who this applies to
- Adults aged 18-65 with prediabetes.
- Individuals seeking to improve glycemic control through lifestyle changes.
Keep in Mind
- Results may not apply to populations outside the study's demographic.
- The effects of the interventions over a longer period remain uncertain.
- Further research is needed to explore the mechanisms behind the observed benefits.
Between the Lines
- The study's sample size and demographic diversity may limit generalizability.
- The long-term effects of the interventions were not assessed.
- Potential confounding factors were not fully controlled.
Evidence Library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Exercise therapy and HbA1c, Exercise therapy and Inflammatory Markers.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Physical Activity
Exercise therapy → HbA1c
Physical Activity
Evidence Intelligence™
- EvidenceScore™
- 81
- Strong
- ImpactScore™
- 84
- Positive
- ConsistencyScore™
- 83
- consistent
Supporting studies: Based on 6 studies
View evidencePhysical Activity
Exercise therapy → Inflammatory Markers
Physical Activity
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 4 studies
- ImpactScore™
- 88
- Very Positive
- ConsistencyScore™
- 75
- consistent
Supporting studies: Based on 4 studies
View evidencePhysical Activity
Exercise therapy → Quality of Life Outcomes
Physical Activity
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 83
- Positive
- ConsistencyScore™
- 67
- generally_consistent
Supporting studies: Based on 3 studies
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Exercise therapy Evidence Hub
All studies on Exercise therapy
6 studies
intervention_hubContributes to Exercise therapy evidence base.
HbA1c Evidence Hub
All studies measuring HbA1c
6 studies
outcome_hubMeasures HbA1c as a key outcome.
Inflammatory Markers Evidence Hub
All studies measuring Inflammatory Markers
4 studies
outcome_hubMeasures Inflammatory Markers as a key outcome.
Quality of Life Outcomes Evidence Hub
All studies measuring Quality of Life Outcomes
3 studies
outcome_hubMeasures Quality of Life Outcomes as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Exercise therapy and HbA1c
Intervention: Exercise therapyOutcome: HbA1c
6 results
All studies on Exercise therapy and Interleukin-6 (IL-6)
Intervention: Exercise therapyOutcome: Interleukin-6 (IL-6)
4 results
All studies on Exercise therapy
Intervention: Exercise therapy
6 results
All studies measuring HbA1c
Outcome: HbA1c
6 results
All studies measuring Interleukin-6 (IL-6)
Outcome: Interleukin-6 (IL-6)
4 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Exercise therapy improve HbA1c?
Strong Evidence
Exercise therapy may improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 81.1 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Exercise therapy improve interleukin-6 (il-6)?
Strong Evidence
Exercise therapy appears to improve Interleukin-6 (IL-6).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Interleukin-6 (IL-6)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Exercise therapy improve quality of life?
Strong Evidence
Exercise therapy may improve Quality of life.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
Quality of life
EvidenceScore™ Strong | EvidenceScore™ 79.0 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Exercise therapy improve fasting blood sugar (fbs)?
Moderate Evidence
Exercise therapy appears to improve Fasting blood sugar (FBS).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Fasting blood sugar (FBS)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Next steps
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Evidence topics
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