Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Synbiotic intake improves calcium and iron levels in type 2 diabetes patients
Last updated September 10, 2026
Key finding
The consumption of a synbiotic food resulted in a significant rise of calcium (0.66 vs. -0.14 mg/dL, P = 0.03).
This study investigated the effects of synbiotic intake on mineral levels, liver enzymes, and blood pressure in patients with type 2 diabetes, finding significant increases in calcium and iron levels.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of synbiotic intake on mineral levels, liver enzymes, and blood pressure in patients with type 2 diabetes, finding significant increases in calcium and iron levels.
Clinical relevance
Improving mineral levels such as calcium and iron is crucial for patients with type 2 diabetes, as these nutrients play vital roles in overall health and metabolic function. The findings suggest that synbiotic foods could be a beneficial dietary addition for managing mineral deficiencies in this population.
Keep in mind
The study did not assess long-term effects of synbiotic intake. Sample size and demographic details were not specified. No significant changes were observed in magnesium or blood pressure.
Published in
Journal Reference
Publication details and source links for this paper.
Zatollah A, Mohammad HA, Mohammad H, et al. Effects of synbiotic intake on minerals, liver enzymes, and blood pressure in patients with type 2 diabetes. International Journal of Preventive Medicine. 2017;8:43. doi:10.4103/ijpvm.IJPVM_257_16
Main Effects
Calcium levels increased significantly by 0.66 mg/dL (P = 0.03) in the synbiotic group.
Iron levels increased significantly by 5.06 mg/dL (P = 0.03) post-synbiotic intake.
Total bilirubin decreased by 0.08 mg/dL (P = 0.009) in the synbiotic group.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Synbiotic intake and Calcium, Diastolic blood pressure, Increased Iron Levels Post-Bariatric Surgery, and 3 more.
This study contributes evidence to
Primary intervention
Synbiotic intake
Primary outcomes
- Calcium
- Diastolic blood pressure
- Increased Iron Levels Post-Bariatric Surgery
Evidence topics
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
6
Evidence pairs
6
Relationships
1
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 59
1
Related topics
6
Evidence pairs
140
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 6 evidence relationships
- Includes primary outcome data
- Linked to 1 direct semantic evidence topic
Topic contributions
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Blood Pressure
matched_outcome
Core evidence
Study findings
The primary outcomes reported in this study.
Diastolic blood pressure
Synbiotic intake → Diastolic blood pressure
Synbiotic intake → Diastolic blood pressure
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerIncreased Iron Levels Post-Bariatric Surgery
Synbiotic intake → Increased Iron Levels Post-Bariatric Surgery
Synbiotic intake → Increased Iron Levels Post-Bariatric Surgery
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerSystolic blood pressure
Synbiotic intake → Systolic blood pressure
Synbiotic intake → Systolic blood pressure
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- Calcium levels rose by 0.66 mg/dL with synbiotic intake.
- Iron levels increased by 5.06 mg/dL post-synbiotic consumption.
- Total bilirubin decreased by 0.08 mg/dL in the synbiotic group.
Who this applies to
- Adults diagnosed with type 2 diabetes.
- Patients seeking dietary interventions to improve mineral levels.
Keep in Mind
- Results may not be generalizable to all populations with diabetes.
- The study focused on short-term effects; long-term benefits are unknown.
- Further research is needed to explore the impact on blood pressure and magnesium.
Between the Lines
- The study did not assess long-term effects of synbiotic intake.
- Sample size and demographic details were not specified.
- No significant changes were observed in magnesium or blood pressure.
Evidence Library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Synbiotic intake and Calcium, Synbiotic intake and Blood Pressure.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Synbiotic intake → Calcium
Supplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceSupplements
Synbiotic intake → Blood Pressure
Supplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Blood Pressure Evidence Hub
All studies measuring Blood Pressure
1 studies
outcome_hubMeasures Blood Pressure as a key outcome.
Calcium Evidence Hub
All studies measuring Calcium
1 studies
outcome_hubMeasures Calcium as a key outcome.
Synbiotic intake Evidence Hub
All studies on Synbiotic intake
1 studies
intervention_hubContributes to Synbiotic intake evidence base.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Synbiotic intake and Calcium
Intervention: Synbiotic intakeOutcome: Calcium
1 results
All studies on Synbiotic intake and Diastolic blood pressure
Intervention: Synbiotic intakeOutcome: Diastolic blood pressure
1 results
All studies on Synbiotic intake
Intervention: Synbiotic intake
1 results
All studies measuring Calcium
Outcome: Calcium
1 results
All studies measuring Diastolic blood pressure
Outcome: Diastolic blood pressure
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Synbiotic intake improve calcium?
Emerging Evidence
Synbiotic intake appears to improve calcium.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Calcium
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Synbiotic intake improve increased iron levels post-bariatric surgery?
Emerging Evidence
Synbiotic intake appears to improve increased iron levels post-bariatric surgery.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Increased Iron Levels Post-Bariatric Surgery
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Synbiotic intake improve total bilirubin?
Emerging Evidence
Synbiotic intake appears to improve total bilirubin.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Total bilirubin
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Synbiotic intake improve diastolic blood pressure?
Emerging Evidence
Current evidence does not show a clear benefit of Synbiotic intake for diastolic blood pressure.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Diastolic blood pressure
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
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