Key finding
Mean between-group difference in the complete-case analysis was -0.13% (95% CI, -0.25 to -0.01), P = 0.04.
A home-based lifestyle intervention with telemedicine support showed modest effects on HbA1c levels in patients with coronary heart disease and type 2 diabetes.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Quick read
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Home-based telemedicine-supported lifestyle intervention
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Primary outcome
Glycated hemoglobin (HbA1c)
Comparator
Usual Care
Plain-language summary
A plain-language read of the study's main message and where it applies.
Study focus
A home-based lifestyle intervention with telemedicine support showed modest effects on HbA1c levels in patients with coronary heart disease and type 2 diabetes.
Improving glycemic control is crucial for patients with CHD and T2DM, as it may reduce the risk of complications. While the intervention showed a modest effect on HbA1c, the lack of significant impact on cardiovascular events highlights the need for comprehensive strategies in managing these patients.
The study had a modest sample size, which may limit the generalizability of the findings. The intervention's long-term effects beyond 12 months were not assessed. The statistical significance of some outcomes was not achieved, indicating uncertainty in effectiveness.
Published in
Publication details and source links for this paper.
Stephan M, Sophia MTD, Felix G, et al. A home-based lifestyle intervention with telemedicine support showed modest effects in patients with CHD and T2DM. Nature Medicine. 2025;31(4):1203-1213. doi:10.1038/s41591-025-03498-w
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The lifestyle intervention reduced HbA1c by -0.13% (95% CI, -0.25 to -0.01), P = 0.04.
At 12 months, 31 patients (6.2%) experienced a major adverse cardiovascular event; P = 0.15.
Hospitalizations for angina or revascularization were higher in the lifestyle intervention group (n = 15) compared to usual care (n = 8).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Lifestyle intervention for prediabetes and Composite cardiovascular events (CV death, MI, stroke, HF hospitalization), Deaths, HbA1c, and 2 more.
This study contributes evidence to
Primary intervention
Lifestyle intervention for prediabetes
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
5
Evidence pairs
194
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
The primary outcomes reported in this study.
Lifestyle intervention for prediabetes → Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
Lifestyle intervention for prediabetes → Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
Evidence profile
Lifestyle intervention for prediabetes → Deaths
Lifestyle intervention for prediabetes → Deaths
Evidence profile
Lifestyle intervention for prediabetes → HbA1c
Lifestyle intervention for prediabetes → HbA1c
Evidence profile
Lifestyle intervention for prediabetes → Hospitalizations
Lifestyle intervention for prediabetes → Hospitalizations
Evidence profile
Lifestyle intervention for prediabetes → Hospitalizations for angina or revascularization
Lifestyle intervention for prediabetes → Hospitalizations for angina or revascularization
Evidence profile
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Lifestyle intervention for prediabetes and HbA1c.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Lifestyle intervention for prediabetes
Contributes to Lifestyle intervention for prediabetes evidence base.
Latest published studies
Published within the last 2 years.
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4 results
4 results
4 results
Generated from the study's connected evidence using Evidence Intelligence™.
Lifestyle intervention for prediabetes appears to improve HbA1c.
ConsensusScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 58.4 | strong positive | ConsensusScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Lifestyle intervention for prediabetes for Composite cardiovascular events (CV death, MI, stroke, HF hospitalization).
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
EvidenceScore™ Limited | EvidenceScore™ 35.4 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Lifestyle intervention for prediabetes for Deaths.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Deaths
EvidenceScore™ Limited | EvidenceScore™ 35.4 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Lifestyle intervention for prediabetes for Hospitalizations.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Hospitalizations
EvidenceScore™ Limited | EvidenceScore™ 35.4 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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