Last updated July 11, 2026
Key finding
Postoperative VAS scores were significantly lower than preoperative (P<0.05).
This study investigated the effects of ultrasound-guided stellate ganglion pulsed radiofrequency therapy on painful diabetic peripheral neuropathy in type 2 diabetes patients, finding significant postoperative improvements in pain and quality of life.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study investigated the effects of ultrasound-guided stellate ganglion pulsed radiofrequency therapy on painful diabetic peripheral neuropathy in type 2 diabetes patients, finding significant postoperative improvements in pain and quality of life.
Managing painful diabetic peripheral neuropathy is crucial for improving the quality of life in patients with type 2 diabetes. The findings suggest that ultrasound-guided stellate ganglion pulsed radiofrequency therapy may offer a new, effective treatment option, potentially reducing reliance on medications and enhancing patient outcomes.
Non-randomized design limits the ability to draw causal conclusions. Sample size may restrict generalizability of findings. Lack of long-term follow-up data on treatment effects.
Published in
Publication details and source links for this paper.
Jiying W, Weisheng X, Qingqing W, et al. Ultrasound-guided stellate ganglion pulsed radiofrequency therapy for painful diabetic peripheral neuropathy in type 2 diabetes mellitus patients. Journal of Pain Research. 2024;17:4521-4531. doi:10.2147/JPR.S497061
Postoperative VAS scores decreased significantly by 3.28 points (P<0.001).
Postoperative SF-MPQ scores decreased significantly by 9.38 points (P<0.001).
Postoperative KPS values increased significantly by 4.36 points (P<0.001).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion and Depression severity measured by PHQ-9, Neuropathic pain severity, Pain Disability Index (PDI), and 10 more.
This study contributes evidence to
Primary intervention
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
13
Evidence pairs
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Related studies
Core evidence
The primary outcomes reported in this study.
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Depression severity measured by PHQ-9
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Depression severity measured by PHQ-9
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Neuropathic pain severity
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Neuropathic pain severity
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Pain Disability Index (PDI)
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Pain Disability Index (PDI)
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Pain severity measured by Simplified McGill Pain Questionnaire (SF-MPQ)
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Pain severity measured by Simplified McGill Pain Questionnaire (SF-MPQ)
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Patient-reported Pain Relief
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Patient-reported Pain Relief
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Patient-reported relief from chills
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Patient-reported relief from chills
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Patient-reported relief from numbness
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Patient-reported relief from numbness
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Postoperative Rate of Analgesic Use
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Postoperative Rate of Analgesic Use
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Quality of life measured by Karnofsky Performance Status (KPS)
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Quality of life measured by Karnofsky Performance Status (KPS)
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Significant Pain Relief Rate
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Significant Pain Relief Rate
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Sleep Duration at Night
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Sleep Duration at Night
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Toronto Clinical Scoring System (TCSS)
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Toronto Clinical Scoring System (TCSS)
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Total Effective Rate of Treatment
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion → Total Effective Rate of Treatment
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion and Depression severity measured by PHQ-9, Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion and Quality of life measured by Karnofsky Performance Status (KPS).
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Depression severity measured by PHQ-9
Measures Depression severity measured by PHQ-9 as a key outcome.
All studies measuring Quality of life measured by Karnofsky Performance Status (KPS)
Measures Quality of life measured by Karnofsky Performance Status (KPS) as a key outcome.
All studies on Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion
Contributes to Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion evidence base.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion appears to improve Depression severity measured by PHQ-9.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Depression severity measured by PHQ-9
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion appears to improve Neuropathic pain severity.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Neuropathic pain severity
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion appears to improve Pain Disability Index (PDI).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Pain Disability Index (PDI)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Ultrasound-guided pulsed radiofrequency therapy of the stellate ganglion appears to improve Pain severity measured by Simplified McGill Pain Questionnaire (SF-MPQ).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Pain severity measured by Simplified McGill Pain Questionnaire (SF-MPQ)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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