HarmfulIncrease
Clinical attachment level
Vitamin D supplementation → Clinical attachment level
Vitamin D supplementation → Clinical attachment level
Evidence profile
HarmfulIncreaseClinical Outcomes
Unlock full evidence details
Research Summary
Analyzed using Evidence Intelligence™
Vitamin D3 may improve periodontal health in diabetes
Key finding
Following SRP and Vitamin D supplementation there was a measurably critical reduction in every one of the periodontal clinical indicators in both groups.
This study investigated the effects of Vitamin D3 supplementation alongside scaling and root planing in patients with Type 2 Diabetes Mellitus and periodontitis, finding significant improvements in periodontal health indicators.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Extended (5–20+ y)
Some Concerns bias
Last updated July 8, 2026Quick read
Study at a glance
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Oral Vitamin D3 supplementation
Study type
RCTs
Follow-up
Extended (5–20+ y)
Primary outcome
Plaque Index (PI)
Comparator
No Vitamin D3 supplementation
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
This study investigated the effects of Vitamin D3 supplementation alongside scaling and root planing in patients with Type 2 Diabetes Mellitus and periodontitis, finding significant improvements in periodontal health indicators.
Clinical relevance
Improving periodontal health in patients with diabetes is crucial as it can influence overall health outcomes. This study suggests that adding Vitamin D3 supplementation to standard dental treatments could provide additional benefits, potentially reducing complications associated with both diabetes and periodontal disease.
Keep in mind
Unclear effectiveness of Vitamin D3 supplementation Limited generalizability due to specific population characteristics Potential confounding factors not controlled for
Published in
Journal Reference
Publication details and source links for this paper.
G R, Nubesh SK, Ramesh K, Indrajit K, Syed SHQ, Pavithra RS. Vitamin D3 Supplementation as an Adjunct to Scaling and Root Planing in Patients with Type 2 Diabetes Mellitus and Periodontitis. Journal of Pharmacy & Bioallied Sciences. 2023;15(Suppl 1):S346-S349. doi:10.4103/jpbs.jpbs_543_22
Save this study and add notes to your research library.
Main Effects
Plaque Index decreased by 11.6 units (p=0.001)
Gingival Bleeding Index decreased by 10 units (p=0.001)
Probing Pocket Depth decreased by 2.5 mm (p=0.001)
Clinical Attachment Level increased by 2 mm (p=0.001)
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Vitamin D supplementation and Clinical attachment level, Fasting Plasma Glucose (FPG), Periodontal probing depth, and 3 more.
This study contributes evidence to
Primary intervention
Vitamin D supplementation
Primary outcomes
- Clinical attachment level
- Fasting Plasma Glucose (FPG)
- Periodontal probing depth
Evidence topics
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
6
Evidence pairs
6
Relationships
2
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 65
2
Related topics
6
Evidence pairs
303
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 6 evidence relationships
- Includes primary outcome data
- Linked to 2 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
Study findings
The primary outcomes reported in this study.
NoneNo Change
Fasting Plasma Glucose (FPG)
Vitamin D supplementation → Fasting Plasma Glucose (FPG)
Vitamin D supplementation → Fasting Plasma Glucose (FPG)
Evidence profile
NoneNo ChangeGlycemic Control
Unlock full evidence details
StrongDecrease
Periodontal probing depth
Vitamin D supplementation → Periodontal probing depth
Vitamin D supplementation → Periodontal probing depth
Evidence profile
StrongDecreaseClinical Outcomes
Unlock full evidence details
StrongDecrease
Plaque Index (PI)
Vitamin D supplementation → Plaque Index (PI)
Vitamin D supplementation → Plaque Index (PI)
Evidence profile
StrongDecreaseClinical Outcomes
Unlock full evidence details
StrongDecrease
Reduction in Gingival Bleeding Index following SRP and Vitamin D supplementation
Vitamin D supplementation → Reduction in Gingival Bleeding Index following SRP and Vitamin D supplementation
Vitamin D supplementation → Reduction in Gingival Bleeding Index following SRP and Vitamin D supplementation
Evidence profile
StrongDecreaseClinical Outcomes
Unlock full evidence details
StrongIncrease
Serum concentration of vitamin D
Vitamin D supplementation → Serum concentration of vitamin D
Vitamin D supplementation → Serum concentration of vitamin D
Evidence profile
StrongIncreaseMetabolic Health
Unlock full evidence details
Unlock full evidence analysis
Create a free account to access effectiveness ratings, evidence strength and depth scores, consistency analysis, and direct links to all supporting studies.
Evidence Suggest
- Significant reduction in plaque index by 11.6 units
- Gingival bleeding index reduced by 10 units
- Serum Vitamin D levels increased by 30 ng/mL
Who this applies to
- Adults diagnosed with Type 2 Diabetes Mellitus
- Patients experiencing periodontitis
Keep in Mind
- Results may not apply to non-diabetic populations
- Further research needed to confirm long-term benefits
- Study did not assess other potential confounding health factors
Between the Lines
- Unclear effectiveness of Vitamin D3 supplementation
- Limited generalizability due to specific population characteristics
- Potential confounding factors not controlled for
Unlock Full Analysis
Create a free account to unlock the bias score, detailed effectiveness analysis, and clinical outcomes for this study.
Already have an account?
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Vitamin D supplementation and Serum concentration of vitamin D, Vitamin D supplementation and Reduction in Gingival Bleeding Index following SRP and Vitamin D supplementation.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
Serum concentration of vitamin D Evidence Hub
All studies measuring Serum concentration of vitamin D
4 studies
outcome_hubMeasures Serum concentration of vitamin D as a key outcome.
Vitamin D supplementation Evidence Hub
All studies on Vitamin D supplementation
4 studies
intervention_hubContributes to Vitamin D supplementation evidence base.
Reduction in Gingival Bleeding Index following SRP and Vitamin D supplementation Evidence Hub
All studies measuring Reduction in Gingival Bleeding Index following SRP and Vitamin D supplementation
1 studies
outcome_hubMeasures Reduction in Gingival Bleeding Index following SRP and Vitamin D supplementation as a key outcome.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Vitamin D supplementation and Serum concentration of vitamin D
Intervention: Vitamin D supplementationOutcome: Serum concentration of vitamin D
4 results
All studies on Vitamin D supplementation and Reduction in Gingival Bleeding Index following SRP and Vitamin D supplementation
Intervention: Vitamin D supplementationOutcome: Reduction in Gingival Bleeding Index following SRP and Vitamin D supplementation
1 results
All studies on Vitamin D supplementation
Intervention: Vitamin D supplementation
4 results
All studies measuring Serum concentration of vitamin D
Outcome: Serum concentration of vitamin D
4 results
All studies measuring Reduction in Gingival Bleeding Index following SRP and Vitamin D supplementation
Outcome: Reduction in Gingival Bleeding Index following SRP and Vitamin D supplementation
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Vitamin D supplementation improve serum concentration of vitamin d?
Moderate Evidence
Vitamin D supplementation appears to improve Serum concentration of vitamin D.
ConsensusScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Serum concentration of vitamin D
EvidenceScore™ Moderate | EvidenceScore™ 61.9 | strong positive | ConsensusScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Vitamin D supplementation improve periodontal probing depth?
Emerging Evidence
Vitamin D supplementation appears to improve Periodontal probing depth.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Periodontal probing depth
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Vitamin D supplementation improve plaque index (pi)?
Emerging Evidence
Vitamin D supplementation appears to improve Plaque Index (PI).
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Plaque Index (PI)
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Vitamin D supplementation improve reduction in gingival bleeding index following srp and vitamin d supplementation?
Emerging Evidence
Vitamin D supplementation appears to improve Reduction in Gingival Bleeding Index following SRP and Vitamin D supplementation.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Reduction in Gingival Bleeding Index following SRP and Vitamin D supplementation
EvidenceScore™ Emerging | EvidenceScore™ 52.9 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
Continue your research
Choose a next path through related evidence topics, archive views, and research summaries.
Evidence topics
Follow the topics this study contributes to.
Explore in archive
Open broader archive views for this relationship.
All studies on Vitamin D supplementation and Serum concentration of vitamin DAll studies on Vitamin D supplementation and Periodontal probing depthAll studies on Vitamin D supplementation and Plaque Index (PI)All studies on Vitamin D supplementation and Reduction in Gingival Bleeding Index following SRP and Vitamin D supplementation
Related research
Read related research summaries.
Vitamin D may reduce inflammation in type 2 diabetesVitamin D supplementation may improve musculoskeletal pain in pregnant womenVitamin D supplementation reduces neonatal birth weight in gestational diabetesHigh-dose vitamin D3 does not improve insulin resistance in type 2 diabetesVitamin C may reduce oxidative stress in type 2 diabetes patients.
No ads. No tracking.
Focused on evidence, not advertising.
Secure & private
Your data is always protected.
Always up to date
New studies added every day.