Last updated September 1, 2026
Key finding
Mean weight loss was greater in the intervention (−5.5% [0.6%]) than in the control (−0.4% [0.5%]) group (P < .001).
This study evaluated the efficacy of a 16-week lifestyle intervention on metabolic and behavioral risk factors compared to usual care. The intervention group showed significant improvements in weight and fasting glucose levels.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the efficacy of a 16-week lifestyle intervention on metabolic and behavioral risk factors compared to usual care. The intervention group showed significant improvements in weight and fasting glucose levels.
These findings highlight the potential of structured lifestyle interventions in workplace settings to effectively reduce metabolic risk factors. By improving weight and glucose levels, such interventions can contribute to better long-term health outcomes and reduce the risk of chronic diseases.
Limited generalizability due to specific population characteristics Short duration of the intervention may not reflect long-term effects Potential for unmeasured confounders affecting outcomes
Published in
Publication details and source links for this paper.
Kellie RW, Carla KM, David GM, Haikady NN, Brian CF, Gregg MG. Efficacy of a Worksite Lifestyle Intervention on Metabolic and Behavioral Risk Factors Compared with Usual Care. Preventing Chronic Disease. 2015;12:E210. doi:10.5888/pcd12.150301
Mean weight loss was greater in the intervention group (−5.5%) compared to the control group (−0.4%)
Fasting glucose levels decreased more in the intervention group (−8.6 mg/dL) than in the control group (−3.7 mg/dL)
Total energy intake decreased significantly postintervention
Dietary fiber intake increased significantly postintervention
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Lifestyle intervention for prediabetes, Usual care and Fasting Plasma Glucose (FPG), Fiber intake, UPF percentage contribution to total energy intake at follow-up, and 1 more.
This study contributes evidence to
Primary intervention
Lifestyle intervention for prediabetes
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
5
Evidence pairs
1262
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Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Lifestyle intervention for prediabetes → Fasting Plasma Glucose (FPG)
Lifestyle intervention for prediabetes → Fasting Plasma Glucose (FPG)
Lifestyle intervention for prediabetes → Fiber intake
Lifestyle intervention for prediabetes → Fiber intake
Lifestyle intervention for prediabetes → UPF percentage contribution to total energy intake at follow-up
Lifestyle intervention for prediabetes → UPF percentage contribution to total energy intake at follow-up
Lifestyle intervention for prediabetes → Weight change
Lifestyle intervention for prediabetes → Weight change
Usual care → Fasting Plasma Glucose (FPG)
Usual care → Fasting Plasma Glucose (FPG)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Lifestyle intervention for prediabetes and Fasting Glucose, Usual care and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies on Lifestyle intervention for prediabetes
Contributes to Lifestyle intervention for prediabetes evidence base.
All studies on Usual care
Contributes to Usual care evidence base.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
Jump to pre-filtered views in Evidence Explorer.
9 results
6 results
9 results
6 results
9 results
Generated from the study's connected evidence using Evidence Intelligence™.
Lifestyle intervention for prediabetes may improve fasting plasma glucose (FPG).
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Strong | EvidenceScore™ 87.1 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Current evidence does not show a clear benefit of Usual care for fasting plasma glucose (FPG).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Strong | EvidenceScore™ 84.7 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Lifestyle intervention for prediabetes may improve weight change.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Weight change
EvidenceScore™ Strong | EvidenceScore™ 79.0 | weak positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Lifestyle intervention for prediabetes appears to improve fiber intake.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fiber intake
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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