#1 Hypoglycemia
Insulin Delivery Systems → Hypoglycemia
Evidence Intelligence™
- EvidenceScore™
- 86
- Strong
- ImpactScore™
- 56
- Slightly Positive
- ConsistencyScore™
- 56
- generally_consistent
Estudios de apoyo: Basado en 9 estudios
Explore evidenceSafety
Last updated: 12 de septiembre de 2026
Key takeaway
Safety has evidence across 10 diabetes-related interventions, with strongest support for Insulin Delivery Systems, GLP-1 Receptor Agonists and Insulin Therapies.
Evidence status
Extensive ResearchEvidence Base: 81/100
Related Evidence Topics
Evidence Intelligence™
Every evidence topic is generated from structured relationships across diabetes research, including topics, interventions, outcomes, and individual studies.
270
Evidence relationships
297
Studies reviewed
13
Interventions evaluated
Strongest evidence area
Insulin Delivery Systems
Top Evidence Areas
Showing grouped evidence. Expand in Evidence Explorer for detailed intervention-outcome pairs.Open Evidence Explorer
| Rank | Intervention group | Outcome group | EvidenceScore™ | ImpactScore™ | Consistency | Studies | Effectiveness | Action |
|---|---|---|---|---|---|---|---|---|
| #1 | Insulin Delivery Systems | Hypoglycemia | 86/100Strong | 56/100Slightly Positive | 56/100generally_consistent | 9 | weak_positive | Explore evidence |
| #2 | GLP-1 Receptor Agonists | Gastrointestinal Adverse Events | 83/100Strong | 48/100Neutral | 92/100consistent | 12 | neutral | Explore evidence |
| #3 | Insulin Therapies | Hypoglycemia | 82/100Strong | 64/100Slightly Positive | 57/100generally_consistent | 7 | weak_positive | Explore evidence |
| #4 | GLP-1 Receptor Agonists | Hypoglycemia | 82/100Strong | 57/100Slightly Positive | 93/100consistent | 14 | weak_positive | Explore evidence |
| #5 | Sulfonylureas | Hypoglycemia | Strong | 67/100Slightly Positive | 100/100consistent | 3 | weak_positive | Explore evidence |
| #6 | GLP-1 Receptor Agonists | Urinary Tract Infections | 72/100Moderate | 62/100Slightly Positive | 67/100generally_consistent | 3 | weak_positive | Explore evidence |
| #7 | DPP-4 Inhibitors | Hypoglycemia | Moderate | 75/100Positive | 100/100consistent | 2 | moderate_positive | Explore evidence |
| #8 | Diabetes Self-Management Education and Support (DSMES) Programs | Hypoglycemia | Moderate | 100/100Very Positive | 35/100mixed | 2 | strong_positive | Explore evidence |
| #9 | SGLT2 Inhibitors | Hypoglycemia | Moderate | 50/100Neutral | 100/100consistent | 2 | neutral | Explore evidence |
| #10 | Alpha-glucosidase inhibitors | Hypoglycemia | Emerging | 50/100Neutral | unclear | 1 | neutral | Explore evidence |
#2 Gastrointestinal Adverse Events
GLP-1 Receptor Agonists → Gastrointestinal Adverse Events
Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 48
- Neutral
- ConsistencyScore™
- 92
- consistent
Estudios de apoyo: Basado en 12 estudios
Explore evidence#3 Hypoglycemia
Insulin Therapies → Hypoglycemia
Evidence Intelligence™
- EvidenceScore™
- 82
- Strong
- ImpactScore™
- 64
- Slightly Positive
- ConsistencyScore™
- 57
- generally_consistent
Estudios de apoyo: Basado en 7 estudios
Explore evidence#4 Hypoglycemia
GLP-1 Receptor Agonists → Hypoglycemia
Evidence Intelligence™
- EvidenceScore™
- 82
- Strong
- ImpactScore™
- 57
- Slightly Positive
- ConsistencyScore™
- 93
- consistent
Estudios de apoyo: Basado en 14 estudios
Explore evidence#5 Hypoglycemia
Sulfonylureas → Hypoglycemia
Evidence Intelligence™
- EvidenceScore™
- Strong
- Score 79 · Based on 3 studies
- ImpactScore™
- 67
- Slightly Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 3 estudios
Explore evidence#6 Urinary Tract Infections
GLP-1 Receptor Agonists → Urinary Tract Infections
Evidence Intelligence™
- EvidenceScore™
- 72
- Moderate
- ImpactScore™
- 62
- Slightly Positive
- ConsistencyScore™
- 67
- generally_consistent
Estudios de apoyo: Basado en 3 estudios
Explore evidence#7 Hypoglycemia
DPP-4 Inhibitors → Hypoglycemia
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 75
- Positive
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 2 estudios
Explore evidence#8 Hypoglycemia
Diabetes Self-Management Education and Support (DSMES) Programs → Hypoglycemia
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- 35
- mixed
Estudios de apoyo: Basado en 2 estudios
Explore evidence#9 Hypoglycemia
SGLT2 Inhibitors → Hypoglycemia
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 2 estudios
Explore evidence#10 Hypoglycemia
Alpha-glucosidase inhibitors → Hypoglycemia
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Estudios de apoyo: Basado en 1 estudio
Explore evidencePractical Questions
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
Which interventions have the strongest evidence for affecting Safety?
evidence strengthStrong Evidence
Dulaglutide, Hybrid closed-loop system, and Semaglutide have the strongest available evidence signals for Safety.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Hybrid closed-loop system
EvidenceScore™ Strong | EvidenceScore™ 84.7 | neutral | ConsistencyScore™ Generally Consistent | 5 studies
- 2
Semaglutide
EvidenceScore™ Strong | EvidenceScore™ 78.7 | weak positive | ConsistencyScore™ Consistent | 4 studies
- 3
Dulaglutide
EvidenceScore™ Strong | EvidenceScore™ 76.1 | neutral | ConsistencyScore™ Consistent | 4 studies
Why this answer: This answer is based on 13 supporting studies and existing graph evidence signals.
Which interventions are most often studied for Safety?
most studiedEmerging Evidence
Insulin degludec, Liraglutide, and Semaglutide are among the most studied areas in relation to Safety.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Semaglutide
EvidenceScore™ Strong | EvidenceScore™ 78.7 | weak positive | ConsistencyScore™ Consistent | 12 studies
- 2
Liraglutide
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Mixed | 8 studies
- 3
Insulin degludec
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 4 studies
Why this answer: This answer is based on 24 supporting studies and existing graph evidence signals.
Where are results mixed or inconsistent for Safety?
consistency issuesModerate Evidence
Results are mixed or unclear for Insulin therapy and Liraglutide in relation to Safety.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The evidence includes both beneficial and harmful or worsening results.
Ranked evidence signals
- 1
Insulin therapy
EvidenceScore™ Strong | EvidenceScore™ 79.0 | weak positive | ConsistencyScore™ Mixed | 3 studies
- 2
Liraglutide
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Mixed | 4 studies
Why this answer: This answer is cautious because the available studies report mixed findings.
Which interventions need more research for Safety?
research gapsEmerging Evidence
40% dextrose gel (200 mg/kg) and 40% dextrose gel (400 mg/kg) need more research in relation to Safety.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
40% dextrose gel (200 mg/kg)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
- 2
40% dextrose gel (400 mg/kg)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
How does Hybrid closed-loop system compare with Hybrid closed-loop system for Safety?
compareStrong Evidence
Hybrid closed-loop system have available evidence for Safety, but the comparison requires review of the underlying studies.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Hybrid closed-loop system
EvidenceScore™ Strong | EvidenceScore™ 84.7 | neutral | ConsistencyScore™ Generally Consistent | 7 studies
Why this answer: This answer is based on 7 supporting studies and existing graph evidence signals.
Interventions Studied for Safety
Intervention categories most commonly studied for safety outcomes.
GLP-1 Receptor Agonists
EvidenceScore™ 62/100
Evidence related to GLP-1 receptor agonist therapies in diabetes studies.
41 Studies
Liraglutide
EvidenceScore™ 61/100
Evidence related to liraglutide and liraglutide-containing intervention regimens in diabetes studies.
11 Studies
Insulin Therapies
EvidenceScore™ 60/100
Evidence related to insulin therapies in diabetes studies.
19 Studies
Metformin
EvidenceScore™ 59/100
Evidence related to metformin therapies in diabetes studies.
9 Studies
DPP-4 Inhibitors
EvidenceScore™ 59/100
Evidence related to DPP-4 inhibitor therapies in diabetes studies.
8 Studies
Probiotics and Synbiotics
EvidenceScore™ 59/100
Evidence related to probiotic and synbiotic interventions in diabetes studies.
6 Studies
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Evidence Landscape
Evidence landscape
Each bubble represents an evidence relationship. Position shows effectiveness and EvidenceScoreâ„¢; size reflects study volume.
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- Moderate evidence
- Limited evidence
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