Oxygen-enriched water may modestly lower HbA1c in type 2 diabetes
Key takeaway:
In adults with type 2 diabetes, oxygen-enriched ELO water modestly lowered HbA1c over 12 weeks, while fasting glucose and body weight did not clearly change.
Study at a glance
What was studied
Oxygen-enriched ELO water as add-on therapy for adults with type 2 diabetes
Study type
Randomized Controlled Trials (RCTs)
duration
Short-Term (≤3 mo)
Intervention
Oxygen-enriched water
Outcomes
HbA1c, Fasting glucose, Body weight, Hypoglycemia events, Adverse events incidence
Funding
Industry sponsored
Main effects
HbA1c ↓ (ELO water -0.3 ± 0.7% at 12 weeks)
Fasting plasma glucose → (no significant change in either group)
Body weight → (no significant change in either group)
Evidence Suggest
- ELO water produced a modest within-group HbA1c decrease after 12 weeks in adults with type 2 diabetes.
- The between-group HbA1c change was significant at week 6, and 39.1% of ELO participants had at least a 0.5% HbA1c decrease versus 18.9% with placebo.
- No significant changes were reported for fasting plasma glucose or body weight.
Who this applies to
Adults aged 21 to 70 years with type 2 diabetes
Keep in Mind
Participants were advised not to change diet, exercise, or medications during the study.
Between the Lines
- Short 12-week proof-of-concept trial
- Commercial sponsorship by the ELO water manufacturer
- Small HbA1c change with no significant week-12 between-group difference in Table 1
- No direct human measurements of tissue oxygenation, mitochondrial function, or insulin resistance
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Journal Reference
Khoo J, Hagemeyer CE, Henstridge DC, et al. Effects of water stably-enriched with oxygen as a novel method of tissue oxygenation on mitochondrial function, and as adjuvant therapy for type 2 diabetes in a randomized placebo-controlled trial. PLoS One. 2021;16(7):e0254619. doi:10.1371/journal.pone.0254619
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