Last updated June 15, 2026
Key finding
At week 12, ELO water was associated with significant (p = 0.002) decrease in HbA1c of 0.3 ± 0.7% from baseline.
This 12-week trial tested oxygen-enriched ELO water as an add-on therapy in adults with type 2 diabetes. HbA1c fell modestly in the ELO group, especially by week 6 compared with placebo, but fasting glucose and body weight did not clearly improve.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
Randomized controlled trial
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This 12-week trial tested oxygen-enriched ELO water as an add-on therapy in adults with type 2 diabetes. HbA1c fell modestly in the ELO group, especially by week 6 compared with placebo, but fasting glucose and body weight did not clearly improve.
A safe, simple add-on strategy for lowering HbA1c would be useful for people with type 2 diabetes, especially if it did not require medication changes. This early trial suggests a small glycemic effect, but the clinical importance is uncertain. The short duration, modest HbA1c change, industry sponsorship, and lack of direct human tissue oxygenation or insulin resistance measures limit confidence.
Short 12-week proof-of-concept trial Commercial sponsorship by the ELO water manufacturer Small HbA1c change with no significant week-12 between-group difference in Table 1 No direct human measurements of tissue oxygenation, mitochondrial function, or insulin resistance
HbA1c ↓ (ELO water -0.3 ± 0.7% at 12 weeks)
Fasting plasma glucose → (no significant change in either group)
Body weight → (no significant change in either group)
Evidence network
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This study contributes evidence to Oxygen-enriched water and Adverse events incidence, Body weight, Fasting blood sugar (FBS), and 2 more.
This study contributes evidence to
Primary intervention
Oxygen-enriched water
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
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Evidence pairs
1050
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Contributes evidence
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Primary evidence
Evidence topic
matched_intervention_and_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Oxygen-enriched water → Adverse events incidence
Oxygen-enriched water → Adverse events incidence
Oxygen-enriched water → Fasting blood sugar (FBS)
Oxygen-enriched water → Fasting blood sugar (FBS)
Oxygen-enriched water → Hypoglycemia events
Oxygen-enriched water → Hypoglycemia events
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Oxygen-enriched water and Adverse events incidence, Oxygen-enriched water and Body Weight.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Curated evidence collections and hubs this study is part of.
All studies measuring Adverse events incidence
Measures Adverse events incidence as a key outcome.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
All studies on Oxygen-enriched water
Contributes to Oxygen-enriched water evidence base.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Oxygen-enriched water may improve Adverse events incidence.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Adverse events incidence
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | weak positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Oxygen-enriched water may improve Body weight.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Body weight
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | weak positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Oxygen-enriched water may improve Fasting blood sugar (FBS).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting blood sugar (FBS)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | weak positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Oxygen-enriched water may improve HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | weak positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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