Research Summary

Analyzed using Evidence Intelligence™

Adjunctive therapy improves periodontal outcomes in diabetes patients

Last updated July 22, 2026

Key finding

BOP decreased significantly from baseline (8.08 ± 5.09 for SRP, p < 0.001; 4.21 ± 3.85 for SRP + aPDT, p < 0.001).

This study evaluated the effects of adjunctive periodontal therapy with Indocyanine Green irradiation in patients with Type II diabetes and periodontitis. Significant improvements were observed in clinical outcomes.

Quick read

Study at a glance

The essential study design details in one scan.

EvidenceScore™

Moderate

Study type

RCTs

Follow-up

Medium-Term (3–12 mo)

Risk of bias

Some Concerns

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Plain-language summary

What this paper says

A plain-language read of the study’s main message and where it applies.

Study focus

Clinical relevance

These findings are significant as they suggest that incorporating advanced therapies like Indocyanine Green irradiation could enhance periodontal treatment outcomes for patients with Type II diabetes. Improved periodontal health may lead to better overall diabetes management, reducing complications associated with both conditions.

Keep in mind

The study did not include a long-term follow-up to assess sustained effects. Sample size and demographic characteristics may limit generalizability. The study did not evaluate potential confounding factors influencing outcomes.

Published in

Journal Reference

Publication details and source links for this paper.

Irina-Georgeta S, Maria-Alexandra M, Ionut L, et al. Effects of Adjunctive Periodontal Therapy with Indocyanine Green Irradiation in Patients with Type II Diabetes and Periodontitis. Diagnostics. 2022;12(7):1614. doi:10.3390/diagnostics12071614

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Main Effects

Bleeding on Probing Index decreased significantly (SRP: 8.08 ± 5.09 to 4.21 ± 3.85, p < 0.001)

Probing Depth decreased significantly (SRP: 4.10 ± 0.22 mm to 3.56 ± 0.19 mm, p < 0.001)

Clinical Attachment Level decreased significantly (SRP: 3.15 ± 0.17 mm to 2.58 ± 0.19 mm, p < 0.001)

Glycated Hemoglobin A1c decreased significantly (SRP: 6.28 ± 0.24 to 6.262 ± 0.040, p < 0.001)

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to SRP + OHI and Bleeding on probing, Clinical attachment level, HbA1c, and 2 more.

This study contributes evidence to

Intervention

SRP + OHI

Outcome

Bleeding on probing

Evidence topic

HbA1c Reduction

Primary intervention

SRP + OHI

Primary outcomes

Bleeding on probing
Clinical attachment level
HbA1c

Evidence topics

HbA1c Reduction

Primary intervention

SRP + OHI

Primary outcomes

Bleeding on probing Clinical attachment level HbA1c

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

Evidence pairs

Relationships

Evidence topics

contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 59

Why it is useful

Contributes to 5 evidence relationships
Includes primary outcome data
Linked to 1 direct semantic evidence topic

Topic contributions

Evidence topic

Contributes evidence

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Primary evidence

Evidence topic

HbA1c Reduction

matched_outcome

Core evidence

Study findings

The primary outcomes reported in this study.

Bleeding on probing

SRP + OHI → Bleeding on probing

Evidence Intelligence™

EvidenceScore™: Strong; Score 79 · Based on 4 studies
ImpactScore™: 100; Very Positive
ConsistencyScore™: 100; consistent

Based on 4 studies

Add to Evidence Tracker

Clinical attachment level

SRP + OHI → Clinical attachment level

Evidence Intelligence™

EvidenceScore™: 84; Strong
ImpactScore™: 83; Positive
ConsistencyScore™: 67; generally_consistent

Based on 6 studies

Add to Evidence Tracker

HbA1c

SRP + OHI → HbA1c

Evidence Intelligence™

EvidenceScore™: Strong; Score 79 · Based on 4 studies
ImpactScore™: 63; Slightly Positive
ConsistencyScore™: 35; mixed

Based on 4 studies

Add to Evidence Tracker

Periodontal probing depth

SRP + OHI → Periodontal probing depth

Evidence Intelligence™

EvidenceScore™: 83; Strong
ImpactScore™: 100; Very Positive
ConsistencyScore™: 100; consistent

Based on 7 studies

Add to Evidence Tracker

Plaque Index (PI)

SRP + OHI → Plaque Index (PI)

Evidence Intelligence™

EvidenceScore™: Strong; Score 79 · Based on 4 studies
ImpactScore™: 75; Positive
ConsistencyScore™: 35; mixed

Based on 4 studies

Add to Evidence Tracker

Evidence Library

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Evidence Suggest

Bleeding on Probing decreased by 63.68% with significant p-value.
Probing Depth reduced by 1.4 mm, indicating improved periodontal health.
Glycated Hemoglobin A1c decreased by 0.26%, suggesting better diabetes control.

Who this applies to

Adults diagnosed with Type II diabetes.
Patients suffering from periodontitis.

Keep in Mind

Results may not be applicable to non-diabetic populations.
Further studies are needed to confirm long-term benefits.
The effectiveness of aPDT compared to other adjunctive therapies was not assessed.

Between the Lines

The study did not include a long-term follow-up to assess sustained effects.
Sample size and demographic characteristics may limit generalizability.
The study did not evaluate potential confounding factors influencing outcomes.

Evidence Library

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Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

This study contributes to evidence on SRP + OHI and Clinical attachment level, SRP + OHI and Periodontal probing depth.

Related evidence relationships

Explore in Evidence Explorer

This study contributes to the evidence on the following intervention-outcome relationships.

Procedures

Detailed evidence

SRP + OHI → Clinical attachment level

Procedures

Evidence Intelligence™

EvidenceScore™: 84; Strong
ImpactScore™: 83; Positive
ConsistencyScore™: 67; generally_consistent

Based on 6 studies

View evidence

Procedures

Detailed evidence

SRP + OHI → Periodontal probing depth

Procedures

Evidence Intelligence™

EvidenceScore™: 83; Strong
ImpactScore™: 100; Very Positive
ConsistencyScore™: 100; consistent

Based on 7 studies

View evidence

Included in these evidence collections

Curated evidence collections and hubs this study is part of.

Periodontal probing depth Evidence Hub

All studies measuring Periodontal probing depth

7 studies

outcome_hub

Measures Periodontal probing depth as a key outcome.

Clinical attachment level Evidence Hub

All studies measuring Clinical attachment level

6 studies

outcome_hub

Measures Clinical attachment level as a key outcome.

SRP + OHI Evidence Hub

All studies on SRP + OHI

6 studies

intervention_hub

Contributes to SRP + OHI evidence base.

Explore more in Evidence Explorer

Jump to pre-filtered views in Evidence Explorer.

All studies on SRP + OHI and Clinical attachment level

Intervention: SRP + OHIOutcome: Clinical attachment level

6 results

All studies on SRP + OHI and Periodontal probing depth

Intervention: SRP + OHIOutcome: Periodontal probing depth

7 results

All studies on SRP + OHI

Intervention: SRP + OHI

6 results

All studies measuring Clinical attachment level

Outcome: Clinical attachment level

6 results

All studies measuring Periodontal probing depth

Outcome: Periodontal probing depth

7 results

Questions answered by this study

Generated from the study's connected evidence using Evidence Intelligence™.

Does SRP + OHI improve clinical attachment level?

Strong Evidence

SRP + OHI may improve Clinical attachment level.

ConsistencyScore™: Results are generally consistent across studies.

Ranked evidence signals

1
Clinical attachment level
EvidenceScore™ Strong | EvidenceScore™ 83.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Population details are unavailable.

View Full Evidence

Does SRP + OHI improve periodontal probing depth?

Strong Evidence

SRP + OHI appears to improve Periodontal probing depth.

ConsistencyScore™: Results are consistent across studies.

Ranked evidence signals

1
Periodontal probing depth
EvidenceScore™ Strong | EvidenceScore™ 83.5 | strong positive | ConsistencyScore™ Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Population details are unavailable.

View Full Evidence

Does SRP + OHI improve bleeding on probing?

Strong Evidence

SRP + OHI appears to improve Bleeding on probing.

ConsistencyScore™: Results are consistent across studies.

Ranked evidence signals

1
Bleeding on probing
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Population details are unavailable.

View Full Evidence

Does SRP + OHI improve plaque index (pi)?

Strong Evidence

SRP + OHI may improve Plaque Index (PI).

ConsistencyScore™: Results are mixed and should be interpreted cautiously.

Evidence caveat: The available evidence reports mixed findings.

Ranked evidence signals

1
Plaque Index (PI)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | moderate positive | ConsistencyScore™ Mixed | 1 study

Why this answer: This answer is cautious because the available studies report mixed findings.

Limitations

Only one supporting study is available.
Population details are unavailable.

View Full Evidence

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Next steps

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Evidence topics

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HbA1c Reduction Evidence Hub

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All studies on SRP + OHI and Clinical attachment level All studies on SRP + OHI and Periodontal probing depth All studies on SRP + OHI and Bleeding on probing All studies on SRP + OHI and HbA1c

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