Last updated August 16, 2026
Key finding
PPD decreased from 3.3 ± 0.2 mm to 2.6 ± 0.2 mm in the test group.
This study investigated the impact of antimicrobial photodynamic therapy on periodontal disease and glycaemic control in patients with type 2 diabetes. Results indicated improvements in probing pocket depth and full-mouth bleeding scores.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the impact of antimicrobial photodynamic therapy on periodontal disease and glycaemic control in patients with type 2 diabetes. Results indicated improvements in probing pocket depth and full-mouth bleeding scores.
Improving periodontal health in diabetic patients is crucial, as periodontal disease can exacerbate diabetes complications. This study suggests that antimicrobial photodynamic therapy could be a beneficial adjunctive treatment for managing periodontal disease in this population, potentially leading to better overall health outcomes.
Sample size may limit the generalizability of the findings. The study did not assess long-term effects beyond the intervention period. Differences in baseline characteristics between groups were not detailed.
Published in
Publication details and source links for this paper.
Sara B, Aleš S, Boris G, Rok S. The effect of concomitant antimicrobial photodynamic therapy on periodontal disease and glycaemic control in patients with type 2 diabetes mellitus. Clinical Oral Investigations. 2023;27(10):6235-6244. doi:10.1007/s00784-023-05239-0
Probing pocket depth decreased by 0.7 mm in the test group (p=0.01).
Full-mouth bleeding score decreased by 14.7% in the test group (p=0.001).
Clinical attachment loss decreased by 0.5 mm in the test group (p=0.01).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Antimicrobial photodynamic therapy (aPTD), Full-mouth disinfection and Clinical attachment level, Full mouth bleeding score, Gingival recession measurement, and 3 more.
This study contributes evidence to
Primary intervention
Antimicrobial photodynamic therapy (aPTD)
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
11
Evidence pairs
348
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Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Antimicrobial photodynamic therapy (aPTD) → Clinical attachment level
Antimicrobial photodynamic therapy (aPTD) → Clinical attachment level
Antimicrobial photodynamic therapy (aPTD) → Full mouth bleeding score
Antimicrobial photodynamic therapy (aPTD) → Full mouth bleeding score
Antimicrobial photodynamic therapy (aPTD) → Gingival recession measurement
Antimicrobial photodynamic therapy (aPTD) → Gingival recession measurement
Antimicrobial photodynamic therapy (aPTD) → HbA1c
Antimicrobial photodynamic therapy (aPTD) → HbA1c
Antimicrobial photodynamic therapy (aPTD) → Periodontal probing depth
Antimicrobial photodynamic therapy (aPTD) → Periodontal probing depth
Antimicrobial photodynamic therapy (aPTD) → Presence of Tannerella forsythia in subgingival plaque samples
Antimicrobial photodynamic therapy (aPTD) → Presence of Tannerella forsythia in subgingival plaque samples
Full-mouth disinfection → Clinical attachment level
Full-mouth disinfection → Clinical attachment level
Full-mouth disinfection → Full mouth bleeding score
Full-mouth disinfection → Full mouth bleeding score
Full-mouth disinfection → Gingival recession measurement
Full-mouth disinfection → Gingival recession measurement
Full-mouth disinfection → Periodontal probing depth
Full-mouth disinfection → Periodontal probing depth
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Antimicrobial photodynamic therapy (aPTD) and Clinical attachment level, Antimicrobial photodynamic therapy (aPTD) and HbA1c.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies on Antimicrobial photodynamic therapy (aPTD)
Contributes to Antimicrobial photodynamic therapy (aPTD) evidence base.
All studies measuring Clinical attachment level
Measures Clinical attachment level as a key outcome.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
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2 results
2 results
2 results
2 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Antimicrobial photodynamic therapy (aPTD) appears to improve Clinical attachment level.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Clinical attachment level
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Antimicrobial photodynamic therapy (aPTD) appears to improve Periodontal probing depth.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Periodontal probing depth
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Antimicrobial photodynamic therapy (aPTD) for HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Antimicrobial photodynamic therapy (aPTD) appears to improve Full mouth bleeding score.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Full mouth bleeding score
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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